Abstract:
:Electrophysiological studies were performed on the ventral tail nerve of adult rats following intraperitoneal injection of a crude extract of ciguatoxin from known toxic fish flesh. Ciguatoxin induced significant slowing of both mixed and motor nerve conduction velocities and also significant reductions in both motor and mixed nerve amplitudes. Both absolute and supernormal periods were significantly prolonged together with an increase in the magnitude of the supernormal response. These electrophysiological disturbances were modified or blocked by intraperitoneal lidocaine. These findings suggest that lidocaine may have a potential therapeutic application in the treatment of the neurological disturbance in acute ciguatera poisoning in humans.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Cameron J,Flowers AE,Capra MFdoi
10.1002/mus.880160714subject
Has Abstractpub_date
1993-07-01 00:00:00pages
782-6issue
7eissn
0148-639Xissn
1097-4598journal_volume
16pub_type
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