Abstract:
:We studied histopathological changes in the biceps brachii muscle in relation to age and the degree of muscle weakness in 64 patients (aged 11-59 years) with myotonic dystrophy. The proportion of type 1 fibers was unaltered in the adolescent patients compared with control values, but increased with age. The average diameters of all the fiber types were smaller than control values in the adolescents, suggesting immature development; however, there was an increase in diameter with age that was associated with an increase of hypertrophic type 2 fibers. At all ages, type 1 fibers were smaller than type 2 ones. Small angular fibers and small group atrophy consisted mainly of type 1 fibers, their incidences decreasing with age. The severity of muscular weakness was related to the predominance of type 1 fibers, the reduction in the number of hypertrophic type 2 fibers, and the accumulation of adipose cells, but not to the presence of small angular fibers or to small group atrophy.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Tohgi H,Kawamorita A,Utsugisawa K,Yamagata M,Sano Mdoi
10.1002/mus.880170911subject
Has Abstractpub_date
1994-09-01 00:00:00pages
1037-43issue
9eissn
0148-639Xissn
1097-4598journal_volume
17pub_type
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