Abstract:
:We report a patient initially diagnosed as having ocular myasthenia gravis who showed progressive ophthalmoparesis and pseudoblepharospasm together with positive acetylcholine receptor antibodies. Repeated evaluation with high-frequency repetitive stimulation revealed an incremental response and elevated titers of antibodies against presynaptic calcium channels, confirming Lambert-Eaton myasthenic syndrome. Systemic evaluation revealed no malignant neoplasm but revealed euthyroid Hashimoto's disease. Immunomodulative therapy including plasma exchange and administration of an immunosuppressent (azathioprine) combined with a potassium-channel blocker (3,4-diaminopyridine) reduced the ocular abnormalities. We conclude that the ocular manifestations in this patient were probably caused by Lambert-Eaton myasthenic syndrome.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Kanzato N,Motomura M,Suehara M,Arimura Kdoi
10.1002/(sici)1097-4598(199912)22:12<1727::aid-mussubject
Has Abstractpub_date
1999-12-01 00:00:00pages
1727-30issue
12eissn
0148-639Xissn
1097-4598pii
10.1002/(SICI)1097-4598(199912)22:12<1727::AID-MUSjournal_volume
22pub_type
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