Abstract:
:Lamins are the principal components of the nuclear lamina, a network constituting the major structural framework of the nuclear envelope. Alterations in lamin A/C have been associated with a heterogeneous series of human disorders known as laminopathies. We report the finding of a novel deletion in the central rod domain of lamin A/C exon 3 gene in four members of the same family. This genetic alteration was likely responsible for the relatively homogeneous clinical phenotype observed in our three patients, represented by a prominent cardiac conduction-system disease necessitating permanent pacemaker implantation, and limited skeletal involvement manifested by spinal rigidity and contractures. The findings from these cases further expand the clinical spectrum associated with mutations in the LMNA gene.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Maioli MA,Marrosu G,Mateddu A,Solla E,Carboni N,Tacconi P,Lai C,Marrosu MGdoi
10.1002/mus.20879subject
Has Abstractpub_date
2007-12-01 00:00:00pages
828-32issue
6eissn
0148-639Xissn
1097-4598journal_volume
36pub_type
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