Abstract:
INTRODUCTION:When treating ocular myasthenia gravis (MG), the risk/benefit profile of corticosteroids is unclear, and acetylcholinesterase inhibitors are not very effective. We examined the efficacy of topical naphazoline in the treatment of myasthenic blepharoptosis. METHODS:Sixty MG patients with blepharoptosis (32 with ocular symptoms only and 28 with mild generalized symptoms) were enrolled in a multicenter open trial of topical naphazoline. The effects were reported by patients via a questionnaire and were also confirmed for each patient at the clinic. RESULTS:Among 70 eyes of 60 patients, 20 eyes (28.6%) of 17 patients (28.3%) exhibited a marked response (full eye opening), and 24 eyes (34.3%) of 20 patients (33.3%) showed a good response (adequate but incomplete eye opening). Topical naphazoline was evaluated as useful in the treatment of myasthenic blepharoptosis by >70% of the patients. CONCLUSIONS:Topical naphazoline was found to be an effective supplementary symptomatic treatment for myasthenic blepharoptosis.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Nagane Y,Utsugisawa K,Suzuki S,Masuda M,Shimizu Y,Utsumi H,Uchiyama S,Suzuki Ndoi
10.1002/mus.22002subject
Has Abstractpub_date
2011-07-01 00:00:00pages
41-4issue
1eissn
0148-639Xissn
1097-4598journal_volume
44pub_type
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