Multiple descending corticospinal volleys demonstrated by changes of the wrist flexor H-reflex to magnetic motor cortex stimulation in intact human subjects.

Abstract:

:To study noninvasively multiple descending volleys on alpha motoneurons, we used a 30-50% maximum H-reflex in the wrist flexor muscle conditioned by a subthreshold magnetic stimulus of the contralateral motor cortex as a parameter of motoneuronal excitability in seven neurologically healthy subjects. The time interval of the median nerve (test) stimulus and the magnetic (conditioning) stimulus was varied. In all subjects the conditioned H-reflex significantly (P < 0.05) enhanced at conditioning-test intervals between -1 ms and +10 ms. Superimposed on the overall facilitation there were at least two short duration periods of enhanced facilitation in all but one subject. These periods were separated by 2-4 ms and suggest increased excitability at the alpha motoneuronal pool brought on by the descending volleys. We conclude that with subthreshold magnetic cortical stimuli it is possible to produce multiple descending corticospinal volleys, which probably represent descending I waves. This should be taken into account when analyzing motor evoked potentials (MEPs) in clinical studies.

journal_name

Muscle Nerve

journal_title

Muscle & nerve

authors

van der Linden C,Bruggeman R

doi

10.1002/mus.880160406

subject

Has Abstract

pub_date

1993-04-01 00:00:00

pages

374-8

issue

4

eissn

0148-639X

issn

1097-4598

journal_volume

16

pub_type

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