Acquired neuromyotonia and peripheral neuropathy in a patient with Hodgkin's disease.

Abstract:

:Acquired neuromyotonia is characterized by hyperexcitability of motor nerves resulting in continuous muscle fiber activity. It occurs most often as a paraneoplastic syndrome in patients with cancers of the immune system. Antibodies against voltage-gated potassium channels (VGKCs) have been detected in some patients. Peripheral neuropathy is sometimes present. We report on a patient with Hodgkin's lymphoma in complete remission who developed paresthesias followed by neuromyotonia with bulbar involvement. Peripheral sensorimotor neuropathy was diagnosed electrophysiologically and evidence of axonal degeneration and demyelination was detected by sural nerve biopsy. The patient's complaints, including dysarthria, improved after carbamazepine treatment.

journal_name

Muscle Nerve

journal_title

Muscle & nerve

authors

Lahrmann H,Albrecht G,Drlicek M,Oberndorfer S,Urbanits S,Wanschitz J,Zifko UA,Grisold W

doi

10.1002/mus.1078

subject

Has Abstract

pub_date

2001-06-01 00:00:00

pages

834-8

issue

6

eissn

0148-639X

issn

1097-4598

pii

10.1002/mus.1078

journal_volume

24

pub_type

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