Experimental model of alcohol-related peripheral neuropathy.

Abstract:

INTRODUCTION:The aim of this work was to determine the effect of chronic alcohol exposure on peripheral nerves in a nutritionally balanced rat model of alcoholism. METHODS:Three different strains of adult male rats were pair-fed for 8 weeks with isocaloric liquid diets containing 0% or 37% ethanol. Nerve conduction studies (NCS) were performed. Peripheral nerve and muscle were examined histologically with morphometrics. RESULTS:Ethanol exposure significantly slowed velocity in tibial and fibular nerves, but not in the plantar nerve in all 3 strains. Studies of the sciatic nerve revealed decreased fiber diameters and increased regenerative sprouts in peripheral nerves. There was muscle denervation of ethanol-exposed rats in all 3 strains. CONCLUSIONS:Chronic ethanol exposure caused a polyneuropathy characterized by axonal degeneration despite adequate nutrition. These results suggest that ethanol exposure has direct neurotoxic effects on peripheral nerves. This model may be useful in understanding the underlying mechanism(s) of alcohol-related peripheral neuropathy.

journal_name

Muscle Nerve

journal_title

Muscle & nerve

authors

Mellion ML,Nguyen V,Tong M,Gilchrist J,De La Monte S

doi

10.1002/mus.23744

subject

Has Abstract

pub_date

2013-08-01 00:00:00

pages

204-11

issue

2

eissn

0148-639X

issn

1097-4598

journal_volume

48

pub_type

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