Abstract:
:Neuromuscular recovery after peripheral nerve lesion depends on the regeneration of severed axons that re-establish their functional connection with the denervated muscle. The aim of this study was to determine the effects of electrical stimulation (ES) on the neuromuscular recovery after nerve crush injury in rats. Electrical stimulation was carried out on the tibialis anterior (TA) muscle after sciatic nerve crush injury in a rat model. Six ES sessions were administered every other day starting from day 3 postinjury until the end of the experiment (day 14). The sciatic functional index was calculated. Muscle excitability, neural cell adhesion molecule (N-CAM) expression, and muscle fiber cross-sectional area (CSA) were accessed from TA muscle. Regenerated sciatic nerves were analyzed by light and confocal microscopy. Both treated (crush+ES) and untreated (crush) groups had their muscle weight and CSA decreased compared with the normal group (P < 0.05). Electrical stimulation accentuated muscle fiber atrophy more in the crush+ES than in the crush group (P < 0.05). N-CAM expression increased in both crush and crush+ES groups compared with the normal group (P < 0.05). Regenerated nerves revealed no difference between the crush and crush+ES groups. Nevertheless, functional recovery at day 14 post-injury was significantly lower in crush+ES group compared with the crush group. In addition, the crush+ES group had chronaxie values significantly higher on days 7 and 13 compared with the crush group, which indicates a decrease in muscle excitability in the crush+ES animals. The results of this study do not support a benefit of the tested protocol of ES during the period of motor nerve recovery following injury.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Gigo-Benato D,Russo TL,Geuna S,Domingues NR,Salvini TF,Parizotto NAdoi
10.1002/mus.21549subject
Has Abstractpub_date
2010-05-01 00:00:00pages
685-93issue
5eissn
0148-639Xissn
1097-4598journal_volume
41pub_type
杂志文章相关文献
MUSCLE & NERVE文献大全abstract::High-dose immunoglobulins for intravenous administration (IVIg) have originally been developed for substitution therapy in hypogammaglobulinemia. Over the last decade they are increasingly used in the treatment of immune-mediated diseases. In this review the results in immune-mediated neuromuscular diseases are summar...
journal_title:Muscle & nerve
pub_type: 杂志文章,评审
doi:10.1002/(sici)1097-4598(199702)20:2<136::aid-mus1>
更新日期:1997-02-01 00:00:00
abstract:INTRODUCTION:Myotonic dystrophy, or dystrophia myotonica (DM), is characterized by prominent muscle wasting and weakness as well as delayed muscle relaxation resulting from persistent electrical discharges. METHODS:We hypothesized heterogeneity among muscles in degree of weakness and myotonia in an expanded [(CUG)(250...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21988
更新日期:2011-06-01 00:00:00
abstract::We report two female patients with a history of alcohol abuse presenting with proximal painful muscle weakness following aversion therapy with emetine hydrochloride. Muscle biopsy of Case 1 showed a reversible floccular-shaped loss of myosin ATPase and dehydrogenase, an accumulation of PAS positive material, and a nor...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880070109
更新日期:1984-01-01 00:00:00
abstract::Lamins are the principal components of the nuclear lamina, a network constituting the major structural framework of the nuclear envelope. Alterations in lamin A/C have been associated with a heterogeneous series of human disorders known as laminopathies. We report the finding of a novel deletion in the central rod dom...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.20879
更新日期:2007-12-01 00:00:00
abstract:INTRODUCTION:Because paradoxical sleep deprivation (PSD) induces a catabolic hormone profile, we sought to evaluate the morphology of the tibialis anterior (TA) muscle and testosterone and corticosterone levels of paradoxical sleep-deprived rats. METHODS:Three study groups of rats were established: the first group was...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.22322
更新日期:2012-03-01 00:00:00
abstract::Multifocal motor neuropathy (MMN) is a chronic, immune-mediate, peripheral myelinopathy. Inherent in its name, MMN implies involvement of two or more motor nerves. We report three patients with weakness and partial motor conduction block restricted to a single nerve and localized to sites that are not at risk for entr...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.10088
更新日期:2002-05-01 00:00:00
abstract::We investigated 16 patients with Fabry's disease (eight hemizygous men and eight heterozygous women) in one family. We used constant current perception threshold (CPT) testing, which evaluated three major sensory nerve fiber populations, to assess subjective complaints of pain and paresthesias. We also examined clinic...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(199911)22:11<1531::aid-mus
更新日期:1999-11-01 00:00:00
abstract::Force fluctuations in leg muscles increase after bedrest, perhaps due to modulation of the neural strategy that is specific to a muscle or common to agonist muscles. The purpose of this study was to examine the modulation of muscle activity and force fluctuations during steady contractions with variable involvement of...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.20764
更新日期:2007-06-01 00:00:00
abstract:INTRODUCTION:When treating ocular myasthenia gravis (MG), the risk/benefit profile of corticosteroids is unclear, and acetylcholinesterase inhibitors are not very effective. We examined the efficacy of topical naphazoline in the treatment of myasthenic blepharoptosis. METHODS:Sixty MG patients with blepharoptosis (32 ...
journal_title:Muscle & nerve
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1002/mus.22002
更新日期:2011-07-01 00:00:00
abstract::Chronic inflammatory demyelinating polyneuropathy (CIDP) is usually characterized by prominent motor deficits. A pure sensory presentation, labeled chronic sensory demyelinating neuropathy (CSDN), has been reported, but it is unclear if this neuropathy is a distinct clinical and immunologic entity or merely the sensor...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880180411
更新日期:1995-04-01 00:00:00
abstract::In recent years, the following ideas have been expressed: (a) that all cases of a discrete, inherited neuromuscular syndrome should prove to be due to a single biochemical defect, (b) that any single biochemical defect should give rise only to one syndrome, and (c) that an enzymatic defect cannot give rise to a diseas...
journal_title:Muscle & nerve
pub_type: 杂志文章,评审
doi:10.1002/mus.880040107
更新日期:1981-01-01 00:00:00
abstract::Implantation of normal muscle precursor cells (mpc) for treatment for inherited myopathies such as Duchenne muscular dystrophy is in clear need of improvement to become practicable, but few variables have been studied comparatively. Here, we report the first quantitative estimate of the effectiveness of implanting mpc...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4598(199602)19:2<132::AID-MUS2>
更新日期:1996-02-01 00:00:00
abstract::Congenital myasthenic syndromes (CMS) stem from defects in presynaptic, synaptic basal lamina, and postsynaptic proteins. The presynaptic CMS are associated with defects that curtail the evoked release of acetylcholine (ACh) quanta or ACh resynthesis. Defects in ACh resynthesis have now been traced to mutations in cho...
journal_title:Muscle & nerve
pub_type: 杂志文章,评审
doi:10.1002/mus.10269
更新日期:2003-01-01 00:00:00
abstract::We wished to determine whether evoked force output from a human muscle could be inferred from the amplitude and the frequency of evoked muscular sounds. Sounds from adductor pollicis were recorded with a microphone and compared to evoked force changes produced by varying the intensity of nerve stimulation or of volunt...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(199708)20:8<991::aid-mus9>
更新日期:1997-08-01 00:00:00
abstract:INTRODUCTION:Although there are numerous protocols to adjust the amplitude of the Hoffmann reflex (H-reflex) relative to the size of the direct motor response (M-response), the optimal stimulating location has not been described. We sought to determine the optimal positioning of the stimulating cathode when evoking the...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.26308
更新日期:2018-12-01 00:00:00
abstract::Left spinal accessory nerve palsy occurred in a young man when he quickly turned his head to the right while his shoulders were pulled down by heavy hand-held objects. Electrophysiologic studies demonstrated partial axonotmesis of the spinal accessory nerve branches innervating the sternocleidomastoid and upper and mi...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880110210
更新日期:1988-02-01 00:00:00
abstract:INTRODUCTION:Nebulin is a giant actin-binding protein in the thin filament of the skeletal muscle sarcomere. Studies of nebulin interactions are limited by the size, complexity, and poor solubility of the protein. We divided the nebulin super-repeat region into a super-repeat panel, and studied nebulin/actin interactio...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.26350
更新日期:2019-01-01 00:00:00
abstract::The selection of patients who will benefit from peripheral nerve surgery continues to evolve. The evaluation of patients with peripheral nerve problems, and the indications and timing of surgery are reviewed. This includes patients with transections, lesions in continuity, entrapments, tumors, injection injuries, and ...
journal_title:Muscle & nerve
pub_type: 杂志文章,评审
doi:10.1002/(sici)1097-4598(200005)23:5<680::aid-mus4>
更新日期:2000-05-01 00:00:00
abstract::Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and membranous glomerulonephritis (MGN) are both autoimmune disorders that are rarely observed concurrently. We describe a patient who developed MGN nearly 20 years after the onset of CIDP, resulting in a secondary progression of his neuropathy. He respo...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.20841
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:Immobilization induced by experimental denervation leads to rapid and progressive alterations in structural and biochemical properties of skeletal muscle. Real-time reverse transcription-polymerase chain reaction (RT-PCR) is a popular method of elucidating the molecular mechanisms involved in muscle atroph...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.24310
更新日期:2015-02-01 00:00:00
abstract:INTRODUCTION:Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are considered part of the same pathological spectrum. There is an increased risk of ALS in patients who have had melanoma. The risk of FTLD in melanoma (or cancer) patients is unknown. We aimed to study if C9ORF72 expansion i...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.26383
更新日期:2019-03-01 00:00:00
abstract:INTRODUCTION:We examined the effects of pain site and intensity on function in patients with myotonic dystrophy type 1 (DM1) and facioscapulohumeral muscular dystrophy (FSHD) and chronic pain. METHODS:Questionnaires assessing pain sites, pain extent (number of sites), pain intensity, and pain interference were complet...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.24079
更新日期:2014-06-01 00:00:00
abstract::The effect of endurance training on muscle electrical activity during general exercise testing was investigated in physically active patients with chronic obstructive pulmonary disease (COPD). Before and after rehabilitation, patients performed identical incremental exercise tests. Pulmonary gas exchange, venous lacta...
journal_title:Muscle & nerve
pub_type: 临床试验,杂志文章
doi:10.1002/mus.10491
更新日期:2003-12-01 00:00:00
abstract::The motor end-plate fine structure and distribution of junctional acetylcholine receptors (AChRs) in patients with amyotrophic lateral sclerosis (ALS) were studied. Morphometric analysis was carried out in 74 end-plates (92 innervated and 47 denuded postsynaptic regions) from 10 patients with ALS. AChR was studied by ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880070310
更新日期:1984-03-01 00:00:00
abstract::Single-fiber electromyography (SFEMG) demonstrates abnormal jitter in virtually all (99%) patients with myasthenia gravis (MG). One muscle, the extensor digitorum communis, is abnormal in most patients with this disease, but to obtain the maximum diagnostic sensitivity, it may be necessary to examine other muscles, es...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880090904
更新日期:1986-11-01 00:00:00
abstract::Calpain 3 (C3) is the only muscle-specific member of the calcium-dependent protease family. Although neither its physiological function nor its in vivo substrates are known, C3 must be an important protein for normal muscle function as mutations in the C3 gene result in limb-girdle muscular dystrophy type 2A. Previous...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.10465
更新日期:2003-10-01 00:00:00
abstract:INTRODUCTION:Premotor potentials (PMPs) precede compound muscle action potentials evoked from the second lumbrical muscle after median nerve stimulation. Although PMP has been identified as a median sensory nerve action potential, few reports have documented the significance of PMP parameters for diagnosing carpal tunn...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.23424
更新日期:2012-12-01 00:00:00
abstract::We studied the effects of a 12-week progressive resistance strength training program in weakened muscles of 5 patients with sporadic inclusion body myositis (IBM). Strength was evaluated with Medical Research Council (MRC) scale ratings and quantitative isometric and dynamic tests. Changes in serum creatine kinase (CK...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(199710)20:10<1242::aid-mus
更新日期:1997-10-01 00:00:00
abstract:INTRODUCTION:An environmental trigger of sporadic amyotrophic lateral sclerosis (ALS) is supported by geographic disparities in ALS incidence and development of the disease in conjugal couples. This study aims to investigate the incidence of ALS in the Northern New England states of New Hampshire (NH), Vermont (VT), an...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.23761
更新日期:2013-08-01 00:00:00
abstract:INTRODUCTION:Phospholipids are essential components of cellular membranes and are closely associated with cellular functions, but relationships involving skeletal muscle phospholipid profiles and their physiological phenotypes have remained unclear. METHODS:We carried out comprehensive phospholipid analyses using liqu...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.26993
更新日期:2020-09-01 00:00:00