Miconazole enhances nerve regeneration and functional recovery after sciatic nerve crush injury.

Abstract:

INTRODUCTION:Improving axonal outgrowth and remyelination is crucial for peripheral nerve regeneration. Miconazole appears to enhance remyelination in the central nervous system. In this study we assess the effect of miconazole on axonal regeneration using a sciatic nerve crush injury model in rats. METHODS:Fifty Sprague-Dawley rats were divided into control and miconazole groups. Nerve regeneration and myelination were determined using histological and electrophysiological assessment. Evaluation of sensory and motor recovery was performed using the pinprick assay and sciatic functional index. The Cell Counting Kit-8 assay and Western blotting were used to assess the proliferation and neurotrophic expression of RSC 96 Schwann cells. RESULTS:Miconazole promoted axonal regrowth, increased myelinated nerve fibers, improved sensory recovery and walking behavior, enhanced stimulated amplitude and nerve conduction velocity, and elevated proliferation and neurotrophic expression of RSC 96 Schwann cells. DISCUSSION:Miconazole was beneficial for nerve regeneration and functional recovery after peripheral nerve injury. Muscle Nerve 57: 821-828, 2018.

journal_name

Muscle Nerve

journal_title

Muscle & nerve

authors

Lin T,Qiu S,Yan L,Zhu S,Zheng C,Zhu Q,Liu X

doi

10.1002/mus.26033

subject

Has Abstract

pub_date

2018-05-01 00:00:00

pages

821-828

issue

5

eissn

0148-639X

issn

1097-4598

journal_volume

57

pub_type

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