Abstract:
:Chronic and acute administration of epinephrine or related sympathomimetic agents are typically prescribed for the treatment of clinical disorders such as hypotension, anaphylactic and allergic reactions, and bronchial asthma. In addition to its effects on these infirmaties and on carbohydrate metabolism, epinephrine also exerts a positive inotropic effect on fast-contracting skeletal muscle in a variety of animal species. At present, the precise mechanisms responsible for the inotropic effect are not known. This communication reviews the positive inotropic effects of epinephrine on fast-contracting skeletal muscle and discusses possible mechanisms which might mediate this phenomenon. Epinephrine potentiates muscle twitches via the second messenger, cAMP, secondary to hormone binding to membrane-bound beta-receptors. Cyclic AMP then acts to increase carbohydrate metabolism, alter sodium/potassium exchange, phosphorylate myosin isozymes, and/or alter intracellular calcium exchange. Based on theoretical grounds, the first three mechanisms can be excluded. Therefore, it is tentatively hypothesized that the effect is due to cAMP-enhanced calcium exchange within the muscle fiber and/or to increased influx of extracellular calcium. This notion is consistent with the mechanism of the positive inotropic effects of epinephrine on cardiac tissue. If this hypothesis is correct, it would also suggest a role, at least under some conditions, for extracellular calcium in the process of skeletal muscle excitation-contraction coupling.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Williams JH,Barnes WSdoi
10.1002/mus.880121204subject
Has Abstractpub_date
1989-12-01 00:00:00pages
968-75issue
12eissn
0148-639Xissn
1097-4598journal_volume
12pub_type
杂志文章,评审相关文献
MUSCLE & NERVE文献大全abstract:INTRODUCTION:Similar to magnetic resonance imaging (MRI), electrical impedance myography (EIM) is dependent on the presence and location of water in muscle to assess neuromuscular diseases. We compared the 2 technologies in mdx mice to better understand their relationship. METHODS:EIM and MRI, using T2 relaxation and ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.24573
更新日期:2015-10-01 00:00:00
abstract::This study contrasts the developmental patterns of expression of 2 subtypes of the voltage-dependent sodium channel in rat muscle that are differentiated by their immunoreactivity with monoclonal antibodies raised to the purified muscle sodium channel protein. One subtype is found in the transverse tubular (T) system ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880140209
更新日期:1991-02-01 00:00:00
abstract::This article describes a 37-year-old woman with progressive external ophthalmoplegia, peripheral neuropathy, and chronic intractable diarrhea. Laboratory studies disclosed lactic acidosis, ragged red fibers lacking cytochrome c oxidase, high-normal muscular mitochondrial enzymes, demyelinating neuropathy, leukoencepha...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880170616
更新日期:1994-06-01 00:00:00
abstract::In anterior interosseous nerve syndrome and ulnar neuropathy, paralysis or weakness of the flexor digitorum profundus (FDP) muscles has been shown to vary according to the degree of involvement of the median and ulnar nerves, respectively. We traced these nerves in 50 cadaveric specimens in which each FDP was complete...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21281
更新日期:2009-04-01 00:00:00
abstract::The sternocleidomastoid muscle (SCM) is one of the major muscles involved in producing abnormal head position in cervical dystonia patients. This study tested whether doxorubicin chemomyectomy, direct injection of doxorubicin into the SCM to permanently remove muscle fibers, has the potential to be a nonsurgical, perm...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(199811)21:11<1457::aid-mus
更新日期:1998-11-01 00:00:00
abstract::Epstein-Barr virus infection can affect both the central and peripheral nervous system. In some patients this occurs concurrently. Two patients are presented with encephalopathy and acute quadriparesis with diminished reflexes. Positive serology for Epstein-Barr virus was found in both patients. Both patients had a ce...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4598(199608)19:8<1037::AID-MUS1
更新日期:1996-08-01 00:00:00
abstract::The authors reported a large study of 93 children presenting a severe form of progressive muscular dystrophy. The first clinical symptoms were noticed between 3 to 12 years. The atrophy affects, predominantly, the girdle and truncal muscles. The hypertrophy of the calves is almost consistent. The progression of the di...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880060702
更新日期:1983-09-01 00:00:00
abstract::We have examined the clinical features of patients with femoral neuropathy and the factors that influence the prognosis. Of 80 consecutive patients referred for neurophysiological evaluations of proximal lower limb weakness, 32 fulfilled strict inclusion criteria and had adequate information, including estimates of ax...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(199702)20:2<205::aid-mus11
更新日期:1997-02-01 00:00:00
abstract::Focal myositis is a rare inflammatory pseudotumor of skeletal muscle which usually has a benign course. We report a 56-year-old woman with a painful mass in the left arm with a radial nerve palsy. Magnetic resonance imaging (MRI) of the left arm showed a mass in the triceps muscle that was suggestive of a soft-tissue ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(199907)22:7<956::aid-mus25
更新日期:1999-07-01 00:00:00
abstract:INTRODUCTION:Symptoms often return in patients with carpal tunnel syndrome (CTS) who are treated with a local corticosteroid injection. We aimed to determine prognostic factors for a successful long-term outcome. METHODS:We prospectively followed 113 patients who received an injection for CTS. Clinical, electrophysiol...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.22183
更新日期:2011-11-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to evaluate the ultrasound (US) morphological changes of sural nerves (SNs) of uremic patients on hemodialysis. METHODS:Sixty-six SNs in 33 uremic patients were examined by 22-MHZ high-frequency US and routine nerve conduction studies (NCS), and 76 SNs in 38 controls were also ex...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.23418
更新日期:2012-12-01 00:00:00
abstract::If anti-GM1 antibody plays a role in the axonal damage in Guillain-Barré syndrome, the common entrapment sites may be preferentially involved with evidence of axonal dysfunction. To assess this hypothesis, we studied nerve conduction across the cubital tunnel in 44 patients. Abnormal amplitude reduction of compound mu...
journal_title:Muscle & nerve
pub_type: 临床试验,杂志文章
doi:10.1002/(sici)1097-4598(199907)22:7<840::aid-mus5>
更新日期:1999-07-01 00:00:00
abstract::Calpains are Ca2+ -dependent cytosolic cysteine proteases that participate in the pathology of Duchenne muscular dystrophy (DMD). Utrophin is a functional homolog of dystrophin that partially compensates for dystrophin deficiency in myofibers of mdx mice. In this study, we investigated the susceptibility of utrophin t...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.20549
更新日期:2006-06-01 00:00:00
abstract::Myasthenia gravis (MG) exacerbations may be triggered by infections.In the winter of 2009/2010, the Israeli Ministry of Health recommended that each individual with a chronic condition be vaccinated against both the seasonal influenza and the H1N1 virus. We examined vaccination practices in 74 MG patients. Only 38 pat...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.22077
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:A new technique to obtain the sensory nerve action potential (SNAP) of the medial femoral cutaneous nerve is described. METHODS:SNAPs were recorded from 104 subjects with a bar recording electrode 10 cm proximal to the patella along an imaginary line drawn between the medial edge of the patella and the femo...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.26788
更新日期:2020-03-01 00:00:00
abstract::There is evidence that growth hormone may be related to the progression of weakness in Duchenne dystrophy. We conducted a 12-month controlled trial of mazindol, a putative growth hormone secretion inhibitor, in 83 boys with Duchenne dystrophy. Muscle strength, contractures, functional ability and pulmonary function we...
journal_title:Muscle & nerve
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/mus.880131212
更新日期:1990-12-01 00:00:00
abstract::Many patients with the limb-girdle variant of congenital myasthenic syndrome (CMS) possess mutations in the human Dok-7 gene (DOK7). We identified six unrelated CMS patients with DOK7 mutations. Two patients, one mildly and the other moderately affected, were homozygous for the previously described 1263insC mutation. ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.20944
更新日期:2008-04-01 00:00:00
abstract:INTRODUCTION:Pneumothorax is a potentially serious complication of electromyography (EMG). Data on the frequency of pneumothorax after EMG are lacking. The purpose of this study was to determine the frequency, timing, and risk factors for iatrogenic pneumothorax after EMG. METHODS:Cases of pneumothorax after EMG were ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.24883
更新日期:2016-04-01 00:00:00
abstract:INTRODUCTION:The probability and degree of muscle recovery after lesions of long peripheral nerves have not been assessed quantitatively. METHODS:Twelve adults with closed injuries of the fibular division of the sciatic nerve with complete denervation of associated muscles were followed-up for 2-10 years. The onset of...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25103
更新日期:2016-10-01 00:00:00
abstract:INTRODUCTION:Muscle force generation involves recruitment and firing rate modulation of motor units (MUs). The control of MUs in producing multidirectional forces remains unclear. METHODS:We studied MU recruitment and firing properties, recorded from the first dorsal interosseous muscle, for 3 different directions of ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25963
更新日期:2018-01-01 00:00:00
abstract:INTRODUCTION:Duchenne muscular dystrophy (DMD) subjects ≥5 years with nonsense mutations were followed for 48 weeks in a multicenter, randomized, double-blind, placebo-controlled trial of ataluren. Placebo arm data (N = 57) provided insight into the natural history of the 6-minute walk test (6MWT) and other endpoints. ...
journal_title:Muscle & nerve
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/mus.23902
更新日期:2013-09-01 00:00:00
abstract::Cerebral palsy (CP) is the most prevalent neurologic disease in children and a leading cause of severe physical disability. Research and clinical experience indicate that children with CP have abnormal neuromuscular junctions (NMJs), and we present evidence that nonapposition of neuromuscular junction components is as...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.20401
更新日期:2005-11-01 00:00:00
abstract::We have developed an algorithm, called multi-motor unit action potential analysis (MMA), to aid quantification in routine needle EMG examination. In only 5-8 min, it was possible to extract, analyze, and validate 20 motor unit action potentials (MUAPs). In the biceps muscle of normal subjects, the MUAP measurements ar...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880181012
更新日期:1995-10-01 00:00:00
abstract::Electron microscopic studies of long-term denervated rat muscles have identified very small, immature myofibers that are believed to arise from detached satellite cells that have fused to form new fibers within the interstitial space. At present, it is unknown whether and to what extent equivalent fibers exist in dene...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.20902
更新日期:2008-01-01 00:00:00
abstract::At least 50 disease-causing mutations in the skeletal muscle voltage-gated chloride channel gene (CLCN1), almost all of which originate from Caucasian families, have been identified. We investigated a Japanese family with Thomsen's myotonia congenita that included 16 affected individuals (8 men and 8 women) through fi...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/1097-4598(200103)24:3<357::aid-mus1006>3.0
更新日期:2001-03-01 00:00:00
abstract::The F-wave was used to estimate the fastest motor nerve conduction velocity (MNCV) along the proximal segment (spinal cord to knee) of the axons of the tibial nerve in 65 control subjects, 8 patients with diabetic polyneuropathy, and 4 patients with Charcot-Marie-Tooth disease. Terminal latencies and MNCV along the di...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880010303
更新日期:1978-05-01 00:00:00
abstract:INTRODUCTION:Neutral lipid-storage disease with myopathy is caused by mutations in PNPLA2, which produce skeletal and cardiac myopathy. We report a man with multiorgan neutral lipid storage and unusual multisystem clinical involvement, including cognitive impairment. METHODS:Quantitative brain MRI with voxel-based mor...
journal_title:Muscle & nerve
pub_type: 杂志文章,评审
doi:10.1002/mus.24983
更新日期:2016-04-01 00:00:00
abstract::Electrical stimulation was applied daily for 20 minutes to denervated rabbit extensor digitorum longus muscle. One group was stimulated with short tetani, another with 1-Hz frequency, using isometric contractions for both. Tetanic stimulation induced severe fibrosis and is harmful to denervated muscle. One Hertz stimu...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880100206
更新日期:1987-02-01 00:00:00
abstract::Sialorrhea is frequently a socially disabling symptom in patients with bulbar amyotrophic lateral sclerosis (ALS). In this open-label prospective study, we report the effect of botulinum toxin A (Botox) injection into the parotid glands in 10 patients with bulbar ALS and socially disabling sialorrhea. We applied three...
journal_title:Muscle & nerve
pub_type: 临床试验,杂志文章
doi:10.1002/mus.20545
更新日期:2006-08-01 00:00:00
abstract::The nosologic distinction between paramyotonia congenita and hyperkalemic periodic paralysis is somewhat blurred. Muscle membrane inexcitability induced by cooling seems to be characteristic of paramyotonia congenita. The effect of cooling on the maximal compound muscle action potential (CMAP) in patients with paramyo...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880090804
更新日期:1986-10-01 00:00:00