Abstract:
INTRODUCTION:Diagnosis of chronic inflammatory demyelinating polyneuropathy (CIDP) remains uncertain when nerve conduction studies (NCS) fail to show demyelination. METHODS:We conducted a retrospective study of patients who presented with clinical criteria of CIDP in whom electrodiagnostic (EDx) criteria of definite or probable CIDP were missing [axonal sensorimotor neuropathy (n = 23), normal EDx with pure sensory presentation (n = 3)]. All patients received immunomodulatory treatment. Twenty-six patients were evaluated with somatosensory evoked potentials (SSEPs), MRI of spinal roots, cerebrospinal fluid analysis, and/or nerve biopsy. Diagnosis of CIDP was considered to be confirmed in patients who responded to immunotherapy. RESULTS:Twenty-two of 26 patients (85%) had SSEPs reflecting abnormal proximal conduction in sensory fibers, including 14 who had only clinical and SSEP data in favor of CIDP. SSEPs were abnormal in 16 of 20 responders (80%) to immunotherapy. CONCLUSION:SSEP recording contributes to the diagnosis of CIDP when nerve conduction studies fail to detect peripheral demyelination.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Devic P,Petiot P,Mauguiere Fdoi
10.1002/mus.24693subject
Has Abstractpub_date
2016-01-01 00:00:00pages
78-83issue
1eissn
0148-639Xissn
1097-4598journal_volume
53pub_type
杂志文章相关文献
MUSCLE & NERVE文献大全abstract::Acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) were studied in the diaphragm of early postnatal rats, using radiometric determination of enzyme activities, velocity sedimentation for separation of molecular forms, and electron microscopic cytochemistry to localize enzymes. AChE activity did not change s...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880040607
更新日期:1981-11-01 00:00:00
abstract::Weakness is common in both hyper- and hypothyroidism, and skeletal muscle L-carnitine may play a role in this regard, as suggested by studies indicating abnormal levels of carnitine in serum and urine of patients with thyroid dysfunction. Skeletal muscle samples were obtained for carnitine analysis from control subjec...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.20336
更新日期:2005-09-01 00:00:00
abstract::Focal myositis is a rare inflammatory pseudotumor of skeletal muscle which usually has a benign course. We report a 56-year-old woman with a painful mass in the left arm with a radial nerve palsy. Magnetic resonance imaging (MRI) of the left arm showed a mass in the triceps muscle that was suggestive of a soft-tissue ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(199907)22:7<956::aid-mus25
更新日期:1999-07-01 00:00:00
abstract::The mutual links between muscle pain and resting electromyographic (EMG) activity are still controversial. This study described effects of experimental muscle pain on resting EMG activity in a jaw-closing muscle and a leg muscle. Pain was induced by injections of hypertonic saline into the muscles in 10 subjects. Inje...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(199811)21:11<1382::aid-mus
更新日期:1998-11-01 00:00:00
abstract:INTRODUCTION:Motor unit number estimates (MUNEs) provide important information in health, aging, and disease, and can be determined using decomposition-enhanced spike-triggered averaging (DE-STA). Discrimination of surface-detected motor unit potentials (S-MUPs) has been limited to contractile forces of ∽30% maximum vo...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.24092
更新日期:2014-07-01 00:00:00
abstract::We used peristimulus time histograms (PSTHs) to estimate characteristics of the composite excitatory postsynaptic potentials (EPSPs) generated at the anterior horn cell by a descending cortical volley induced by subthreshold transcranial magnetic stimuli in 11 normal subjects, 9 patients with DNA-confirmed Kennedy's d...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(199903)22:3<299::aid-mus2>
更新日期:1999-03-01 00:00:00
abstract::We developed electrophysiologic methods for testing the three major forelimb nerves as a tool to evaluate motor and sensory recovery in rats. Median, ulnar, or radial nerves were transected and repaired in Sprague-Dawley rats. Compound muscle action potentials (CMAPs) and somatosensory evoked potentials (SSEPs) were r...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.20971
更新日期:2008-10-01 00:00:00
abstract::We report on five patients who presented with unilateral or bilateral hypoplasia of the thenar eminence. X rays of the affected limbs showed varying degrees of malformation and underdevelopment of the thumb phalanges and first metacarpal bone, and of the carpal bones at the base of the thumb, indicating a developmenta...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880020604
更新日期:1979-11-01 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a debilitating neurodegenerative disorder with complex biology and significant clinical heterogeneity. Many preclinical and early phase ALS clinical trials have yielded promising results that could not be replicated in larger phase 3 confirmatory trials. One reason for the lack o...
journal_title:Muscle & nerve
pub_type: 杂志文章,评审
doi:10.1002/mus.26801
更新日期:2020-08-01 00:00:00
abstract::A previously reported patient presenting sensory-dominant neuropathy with antiganglioside antibodies, bound preferentially to polysialogangliosides including GD1b, was autopsied. While axonal degeneration was predominant in the sural nerve, many demyelinated fibers were present in the spinal roots. Dorsal roots had un...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(199910)22:10<1426::aid-mus
更新日期:1999-10-01 00:00:00
abstract:INTRODUCTION:Previous studies of limb-girdle muscular dystrophy type 2A (LGMD2A) patients in many countries have suggested a heterogeneous genetic and clinical spectrum, but the genotypes and phenotypes of Chinese LGMD2A patients remain unclear. METHODS:We directly screened calpain-3 (CAPN3) in 18 Chinese Han subjects...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.23381
更新日期:2012-11-01 00:00:00
abstract:INTRODUCTION:We sought to compare median nerve elasticity between leprosy patients (LPs) and healthy volunteers (HVs) using ultrasound elastography (UE). METHODS:Two radiologists independently measured the strain ratio of the median nerve/flexor digitorum superficialis muscle (MN/FDSM) of 18 LP and 18 HV using real-ti...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25510
更新日期:2017-09-01 00:00:00
abstract::Median neuropathies proximal to the wrist are uncommon and usually result from penetrating injuries, fracture dislocation of the distal humerus, or compression by fibrous bands. A 66-year-old man suffered a comminuted fracture of the proximal humerus after a fall. Electrodiagnostic studies revealed a severe proximal m...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(200003)23:3<426::aid-mus15
更新日期:2000-03-01 00:00:00
abstract:INTRODUCTION:Nebulin is a giant actin-binding protein in the thin filament of the skeletal muscle sarcomere. Studies of nebulin interactions are limited by the size, complexity, and poor solubility of the protein. We divided the nebulin super-repeat region into a super-repeat panel, and studied nebulin/actin interactio...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.26350
更新日期:2019-01-01 00:00:00
abstract::The purpose of this study was to determine if chronic fatigue syndrome (CSF) is characterized by abnormalities in oxidative muscle metabolism. Patients with CFS according to Centers for Disease Control (CDC) criteria (n = 22) were compared to normal sedentary subjects (n = 15). CFS patients were also tested before and...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4598(199605)19:5<621::AID-MUS10
更新日期:1996-05-01 00:00:00
abstract:INTRODUCTION:Duchenne muscular dystrophy (DMD) is a degenerative disease of skeletal, respiratory, and cardiac muscles caused by defects in the dystrophin gene. More recently, brain involvement has been verified. Mitochondrial dysfunction and oxidative stress may underlie the pathophysiology of DMD. In this study we ev...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.24704
更新日期:2016-01-01 00:00:00
abstract:INTRODUCTION:Myelinating Schwann cells compartmentalize their outermost layer to form actin-rich channels known as Cajal bands. Herein we investigate changes in Schwann cell architecture and cytoplasmic morphology in a novel mouse model of carpal tunnel syndrome. METHODS:Chronic nerve compression (CNC) injury was crea...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.22276
更新日期:2012-02-01 00:00:00
abstract::A new combined stain for the simultaneous demonstration of motor nerve terminals and cholinesterase at neuromuscular junctions is described. It employs bromoindoxyl acetate dye-staining for cholinesterase and silver-gold impregnation for nerve terminals. The clarity and reliability of the stain permit quantitative mea...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880010110
更新日期:1978-01-01 00:00:00
abstract::Conduction velocity of A delta fibers of the human peripheral nerves was measured by using pain-related somatosensory evoked potentials following CO2 laser stimulation. It was found to be approximately 9 m/s in the forearm as well as in the lower leg. Because conventional conduction study using electric stimulation re...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880141209
更新日期:1991-12-01 00:00:00
abstract::Hindlimb unloading (HU) results in oxidative stress, skeletal muscle atrophy, and increased damage upon reloading. Heat shock proteins (HSPs) protect against oxidative stress. However, it is unknown whether HSPs are depressed with long-term unloading (28 days) or reloading. We tested the hypotheses that long-term HU w...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.20454
更新日期:2006-02-01 00:00:00
abstract::Since peripheral nerve has a large ischemic safety factor, hypothermia, by reducing metabolic demands, is potentially an efficacious technique to rescue nerve from ischemic fiber degeneration (IFD). We therefore evaluated the influence of temperature on the severity of IFD resulting from a standard ischemic stress. Is...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4598(199602)19:2<203::AID-MUS12
更新日期:1996-02-01 00:00:00
abstract::Skeletal muscle involvement can occur at all stages of human immunodeficiency virus (HIV) infection, and may represent the first manifestation of the disease. Myopathies in HIV-infected patients are classified as follows: (1) HIV-associated myopathies and related conditions, including HIV polymyositis, inclusion-body ...
journal_title:Muscle & nerve
pub_type: 杂志文章,评审
doi:10.1002/mus.20338
更新日期:2005-09-01 00:00:00
abstract::To identify the underlying physiological mechanisms for the difference in the time to failure for two types of fatiguing contractions, 20 subjects performed force and position tasks with the elbow flexor muscles at a comparable net muscle torque for a similar duration. Prior to terminating each task, blood flow was oc...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.20241
更新日期:2005-01-01 00:00:00
abstract::Ion channels are complex proteins that span the lipid bilayer of the cell membrane, where they orchestrate the electrical signals necessary for normal function of the central nervous system, peripheral nerve, and both skeletal and cardiac muscle. The role of ion channel defects in the pathogenesis of numerous disorder...
journal_title:Muscle & nerve
pub_type: 杂志文章,评审
doi:10.1002/mus.10164
更新日期:2002-09-01 00:00:00
abstract::A 3-month-old boy with hypotonia at birth succumbed to a congenital myopathy. The major finding in his muscle biopsy corresponded to I-Z-I complexes described previously in embryonic skeletal muscle. A few previous myopathy cases have described findings suggestive of I-Z-I-like complexes. A mutation affecting mononucl...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21575
更新日期:2010-05-01 00:00:00
abstract::Lymphoma occasionally affects the peripheral nervous system. When it does, the diagnosis can be elusive since many patients present without known lymphoma. Most peripheral nerve complications are due to non-Hodgkin's lymphoma (NHL), which infiltrates nerves causing axonal damage. This disorder can affect nerve roots a...
journal_title:Muscle & nerve
pub_type: 杂志文章,评审
doi:10.1002/mus.20163
更新日期:2005-03-01 00:00:00
abstract::High-dose immunoglobulins for intravenous administration (IVIg) have originally been developed for substitution therapy in hypogammaglobulinemia. Over the last decade they are increasingly used in the treatment of immune-mediated diseases. In this review the results in immune-mediated neuromuscular diseases are summar...
journal_title:Muscle & nerve
pub_type: 杂志文章,评审
doi:10.1002/(sici)1097-4598(199702)20:2<136::aid-mus1>
更新日期:1997-02-01 00:00:00
abstract:INTRODUCTION:In this study we estimated the costs paid by U.S. health plans for treating myasthenia gravis (MG) in 2009 and determined the major cost drivers. METHODS:One hundred thirteen MG patients were matched by propensity scores with 339 non-MG patients from a comprehensive health-care insurance database. The mea...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.22327
更新日期:2012-03-01 00:00:00
abstract::Patients with peripheral neuropathy frequently suffer from positive sensory (pain and paresthesias) and motor (muscle cramping) symptoms even in the recovery phase of the disease. To investigate the pathophysiology of increased axonal excitability in peripheral nerve regeneration, we assessed the temporal and spatial ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21031
更新日期:2008-06-01 00:00:00
abstract:INTRODUCTION:Widespread musculoskeletal pain is a well-known symptom of myotonic dystrophy type 2 (DM2), but so far it has been addressed in only a few studies. METHODS:A postal survey for all traceable DM2 patients (n = 132) was conducted. A specific questionnaire, and severity and interference subscales of the Brief...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.22249
更新日期:2012-01-01 00:00:00