Muscle carnitine in hypo- and hyperthyroidism.

Abstract:

:Weakness is common in both hyper- and hypothyroidism, and skeletal muscle L-carnitine may play a role in this regard, as suggested by studies indicating abnormal levels of carnitine in serum and urine of patients with thyroid dysfunction. Skeletal muscle samples were obtained for carnitine analysis from control subjects, and from hyperthyroid and hypothyroid patients before and after treatment. There was a significant reduction in carnitine, especially the esterified portion, in hyperthyroid individuals, with a return to normal as euthyroid status was regained. In hypothyroid patients, there was a trend for carnitine to be lower than normal and for improvement once euthyroid status was attained. Our data indicate that muscle carnitine levels are affected by both hypo- and hyperthyroidism. A decrease in muscle carnitine in both conditions may contribute to thyroid myopathy.

journal_name

Muscle Nerve

journal_title

Muscle & nerve

authors

Sinclair C,Gilchrist JM,Hennessey JV,Kandula M

doi

10.1002/mus.20336

subject

Has Abstract

pub_date

2005-09-01 00:00:00

pages

357-9

issue

3

eissn

0148-639X

issn

1097-4598

journal_volume

32

pub_type

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