Activity of Krebs cycle enzymes in mdx mice.

Abstract:

INTRODUCTION:Duchenne muscular dystrophy (DMD) is a degenerative disease of skeletal, respiratory, and cardiac muscles caused by defects in the dystrophin gene. More recently, brain involvement has been verified. Mitochondrial dysfunction and oxidative stress may underlie the pathophysiology of DMD. In this study we evaluate Krebs cycle enzymes activity in the cerebral cortex, diaphragm, and quadriceps muscles of mdx mice. METHODS:Cortex, diaphragm, and quadriceps tissues from male dystrophic mdx and control mice were used. RESULTS:We observed increased malate dehydrogenase activity in the cortex; increased malate dehydrogenase and succinate dehydrogenase activities in the diaphragm; and increased citrate synthase, isocitrate dehydrogenase, and malate dehydrogenase activities in the quadriceps of mdx mice. CONCLUSION:This study showed increased activity of Krebs cycle enzymes in cortex, quadriceps, and diaphragm in mdx mice.

journal_name

Muscle Nerve

journal_title

Muscle & nerve

authors

Comim CM,Hoepers A,Ventura L,Freiberger V,Dominguini D,Mina F,Mendonça BP,Scaini G,Vainzof M,Streck EL,Quevedo J

doi

10.1002/mus.24704

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

91-5

issue

1

eissn

0148-639X

issn

1097-4598

journal_volume

53

pub_type

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