Changes in Na(+) channel expression and nodal persistent Na(+) currents associated with peripheral nerve regeneration in mice.

abstract：:Peripheral neuropathy marked by reduced nerve conduction velocities was found in four unrelated children, between the ages of 15 months and 9 years, whose autopsies revealed Leigh's subacute necrotizing encephalomyelopathy. Sural nerve biopsies disclosed primary demyelination and remyelination, as well as loss of myel...

journal_title：Muscle & nerve

authors： Goebel HH,Bardosi A,Friede RL,Kohlschütter A,Albani M,Siemes H

更新日期：1986-02-01 00:00:00

abstract：INTRODUCTION:We sought to determine the specificity of compound muscle action potential (CMAP) durations and amplitudes in a large critical illness neuromyopathy (CINM) cohort relative to controls with other neuromuscular conditions. METHODS:Fifty-eight patients with CINM who had been seen over a 17-year period were r...

journal_title：Muscle & nerve

authors： Kramer CL,Boon AJ,Harper CM,Goodman BP

更新日期：2018-03-01 00:00:00

abstract：:Ten adult myotonic dystrophy patients underwent measurements of lung function, maximal dynamic and static ventilatory efforts, and respiratory muscle electromyography (EMG). EMG studies were performed during spontaneous breathing or when subjects breathed through high inspiratory or expiratory resistive loads. Present...

journal_title：Muscle & nerve

authors： Jammes Y,Pouget J,Grimaud C,Serratrice G

更新日期：1985-09-01 00:00:00

abstract：INTRODUCTION:Amyotrophic lateral sclerosis (ALS) is a debilitating neurologic disorder with poor survival rates and no clear biomarkers for disease diagnosis and prognosis. METHODS:We compared serum microRNA (miRNA) expression from patients with ALS with healthy controls and patients with multiple sclerosis and Alzhei...

journal_title：Muscle & nerve

authors： Raheja R,Regev K,Healy BC,Mazzola MA,Beynon V,Von Glehn F,Paul A,Diaz-Cruz C,Gholipour T,Glanz BI,Kivisakk P,Chitnis T,Weiner HL,Berry JD,Gandhi R

更新日期：2018-08-01 00:00:00

abstract：:Multifocal motor neuropathy (MMN) is a chronic, immune-mediate, peripheral myelinopathy. Inherent in its name, MMN implies involvement of two or more motor nerves. We report three patients with weakness and partial motor conduction block restricted to a single nerve and localized to sites that are not at risk for entr...

journal_title：Muscle & nerve

authors： Felice KJ,Goldstein JM

更新日期：2002-05-01 00:00:00

abstract：INTRODUCTION:To evaluate the sensitivity of electrophysiologic assessments, we compared F-waves and motor and sensory nerve conduction studies (MNCS and SNCS) in patients with diabetes mellitus (DM). METHODS:We tested median, ulnar, tibial, and fibular nerves in 132 DM patients divided into those with and without clin...

journal_title：Muscle & nerve

authors： Pan H,Jian F,Lin J,Chen N,Zhang C,Zhang Z,Ding Z,Wang Y,Cui L,Kimura J

更新日期：2014-06-01 00:00:00

abstract：:Limb-girdle muscular dystrophy type 2A (LGMD2A) is an autosomal-recessive disorder characterized by selective atrophy and progressive weakness of proximal girdle muscles. LGMD2A, the most prevalent form of LGMD, is caused by mutations in the CAPN3 gene that encodes the skeletal muscle-specific member of the calpain fa...

journal_title：Muscle & nerve

authors： Hermanová M,Zapletalová E,Sedlácková J,Chrobáková T,Letocha O,Kroupová I,Zámecník J,Vondrácek P,Mazanec R,Maríková T,Vohánka S,Fajkusová L

更新日期：2006-03-01 00:00:00

abstract：:We describe a young woman with typical neurovascular symptoms of thoracic outlet syndrome (TOS). A three-dimensional computerized scan showed a "dislocation" of the first rib at the costotransverse joint. The patient responded to a conservative approach to treatment. The patient presented here demonstrates the functio...

journal_title：Muscle & nerve

authors： Lindgren KA,Manninen H,Rytkönen H

更新日期：1995-05-01 00:00:00

abstract：:In this study we investigated the gene expression of proteins related to myostatin (MSTN) signaling during skeletal muscle longitudinal growth. To promote muscle growth, Wistar male rats were submitted to a stretching protocol for different durations (12, 24, 48, and 96 hours). Following this protocol, soleus weight a...

journal_title：Muscle & nerve

authors： Aoki MS,Soares AG,Miyabara EH,Baptista IL,Moriscot AS

更新日期：2009-12-01 00:00:00

abstract：:There is evidence that growth hormone may be related to the progression of weakness in Duchenne dystrophy. We conducted a 12-month controlled trial of mazindol, a putative growth hormone secretion inhibitor, in 83 boys with Duchenne dystrophy. Muscle strength, contractures, functional ability and pulmonary function we...

journal_title：Muscle & nerve

authors： Griggs RC,Moxley RT 3rd,Mendell JR,Fenichel GM,Brooke MH,Miller PJ,Mandel S,Florence J,Schierbecker J,Kaiser KK

更新日期：1990-12-01 00:00:00

abstract：:Injuries to the lumbosacral plexus during labor and delivery have been reported in the literature for years, but have lacked electrophysiologic testing to substantiate the location of the nerve injury. We report 2 cases with comprehensive electrophysiologic testing which localizes the site of this obstetrical paralysi...

journal_title：Muscle & nerve

authors： Feasby TE,Burton SR,Hahn AF

更新日期：1992-08-01 00:00:00

abstract：BACKGROUND:We aimed at evaluating the differential involvement of large myelinated Aβ-, small myelinated Aδ-, and unmyelinated C-fibers in patients with diabetic polyneuropathy and how they contribute to neuropathic pain. METHODS:We collected clinical and diagnostic test variables in 133 consecutive patients with diab...

journal_title：Muscle & nerve

authors： Galosi E,Di Pietro G,La Cesa S,Di Stefano G,Leone C,Fasolino A,Di Lionardo A,Leonetti F,Buzzetti R,Mollica C,Cruccu G,Truini A

更新日期：2021-01-01 00:00:00

abstract：INTRODUCTION:Twenty-six patients with clinical symptoms of adult onset carnitine palmitoyltransferase II (CPTII) deficiency were examined. All patients had skeletal muscle CPTII enzyme activity levels indicative of heterozygosity for CPT2 mutations, however sequence analysis identified no pathogenic mutations within th...

journal_title：Muscle & nerve

authors： Isackson PJ,Sutton KA,Hostetler KY,Vladutiu GD

更新日期：2013-02-01 00:00:00

abstract：:Polylysines, polyornithine, and protamine increased the release of creatine kinase (CK) and lactate dehydrogenase (LDH) from frog muscles. With 5 micrograms/ml (50 nM) of a polylysine of molecular weight 100,000, enzyme release reached peak values (ten-fold above control) within 30 minutes; subsequent removal of the p...

journal_title：Muscle & nerve

authors： Suarez-Kurtz G

更新日期：1985-02-01 00:00:00

abstract：:Nemaline myopathy is a rare disorder of varying severity and genetic etiology. We present two cases, a father and son, with a novel missense mutation in the alpha actin gene. Both have a history of early motor impairment, with the son's course being considerably more severe. This pair illustrates the clinical variabil...

journal_title：Muscle & nerve

authors： Bouldin AA,Parisi MA,Laing N,Patterson K,Gospe SM Jr

更新日期：2007-02-01 00:00:00

abstract：:In normal skeletal muscle, prolonged stimulation results in some cellular adenosine triphosphate (ATP) being converted to adenosine monophosphate (AMP) and then deaminated to inosine monophosphate (IMP). Here, we investigate whether the build-up of IMP contributes to muscle fatigue and also determine what happens if A...

journal_title：Muscle & nerve

authors： Blazev R,Lamb GD

更新日期：1999-12-01 00:00:00

abstract：:The protein compositions of subcellular fractions of muscle obtained from 17 Duchenne dystrophy patients, 15 disease controls (10 different primary myopathies, 5 spinal muscular atrophy patients), and 10 normals were examined by polyacrylamide gel electrophoresis. The gels were stained with Coomassie Brilliant Blue an...

journal_title：Muscle & nerve

authors： Niebroj-Dobosz I,Kornguth S,Schutta H,Siegel FL,Hausmanowa-Petrusewicz I

更新日期：1989-04-01 00:00:00

abstract：INTRODUCTION:Pretreatment with pyridostigmine bromide (PB) of human intercostal muscle fibers exposed to the irreversible acetylcholinesterase (AChE) inhibitor soman was investigated. METHODS:Muscles were pretreated with 3 × 10(-6) M PB or saline for 20 minutes, then exposed to 10(-7) M soman for 10 minutes. RESULTS:...

journal_title：Muscle & nerve

authors： Maselli RA,Henderson JD,Ng J,Follette D,Graves G,Wilson BW

更新日期：2011-04-01 00:00:00

abstract：:Although the effect of low temperature on the peripheral nervous system has been systematically studied, the effect of high temperature has not. We investigated the effect of elevating limb temperature from 32 degrees C to 42 degrees C by performing sequential motor studies, antidromic sensory studies, and 3-Hz repeti...

journal_title：Muscle & nerve

authors： Rutkove SB,Kothari MJ,Shefner JM

更新日期：1997-04-01 00:00:00

abstract：INTRODUCTION:Surface electromyography (SEMG) allows objective assessment and guides selection of appropriate treatment in focal hand dystonia (FHD). METHODS:Sixteen-channel SEMG obtained during different phases of a writing task was used to study timing, activation patterns, and spread of muscle contractions in FHD co...

journal_title：Muscle & nerve

authors： Sivadasan A,Sanjay M,Alexander M,Devasahayam SR,Srinivasa BK

更新日期：2013-09-01 00:00:00

abstract：:Body components were measured noninvasively in patients with neuromuscular disease by using dual-energy X-ray absorptiometry (DXA), capable of separately analyzing fat, bone, and muscle content. In all patients with muscle atrophy of myogenic or neurogenic origin, muscle mass was markedly reduced. Although all three c...

journal_title：Muscle & nerve

authors： Kanda F,Fujii Y,Takahashi K,Fujita T

更新日期：1994-04-01 00:00:00

abstract：:The origins of impaired finger and hand function were examined in 10 stroke survivors with chronic spastic hemiparesis, with the intent of assessing whether mechanical restraint or altered neurophysiological control mechanisms are responsible for the well-known impairment of finger extension. Simultaneous extension of...

journal_title：Muscle & nerve

authors： Kamper DG,Harvey RL,Suresh S,Rymer WZ

更新日期：2003-09-01 00:00:00

abstract：:Guillain-Barré syndrome (GBS) is an inflammatory polyradiculoneuropathy associated with numerous viral infections. Recently, there have been many case reports describing the association between coronavirus disease-2019 (COVID-19) and GBS, but much remains unknown about the strength of the association and the features ...

journal_title：Muscle & nerve

authors： Caress JB,Castoro RJ,Simmons Z,Scelsa SN,Lewis RA,Ahlawat A,Narayanaswami P

更新日期：2020-10-01 00:00:00

abstract：:In spite of extensive studies it is unclear whether impaired fasting glucose (IFG) or impaired glucose tolerance (IGT), i.e., impaired glucose metabolism (IGM), causes diabetic sensorimotor polyneuropathy (DSPN) or chronic idiopathic axonal polyneuropathy (CIAP); the results and conclusions vary considerably in differ...

journal_title：Muscle & nerve

authors： Dyck PJ,Dyck PJ,Klein CJ,Weigand SD

更新日期：2007-10-01 00:00:00

abstract：:In an attempt to determine the relative importance of the nerve cell body and of the axon in initiating and controlling axonal regeneration, nerve cell bodies were irradiated and the ability of the distal axon to sprout was examined. Mice were subjected to either 25 or 50 Gray (Gy) of x-irradiation localized to the lu...

journal_title：Muscle & nerve

authors： Pamphlett RS

更新日期：1988-05-01 00:00:00

abstract：:Calpain 3 (C3) is the only muscle-specific member of the calcium-dependent protease family. Although neither its physiological function nor its in vivo substrates are known, C3 must be an important protein for normal muscle function as mutations in the C3 gene result in limb-girdle muscular dystrophy type 2A. Previous...

journal_title：Muscle & nerve

authors： Guyon JR,Kudryashova E,Potts A,Dalkilic I,Brosius MA,Thompson TG,Beckmann JS,Kunkel LM,Spencer MJ

更新日期：2003-10-01 00:00:00

abstract：:Cortical and spinal somatosensory evoked potentials (SEP) were recorded in healthy individuals following stimulation of digits I, III, and V with an intensity below discomfort level. Peak latency of the earliest cortical negativity (N1) was found to be the most consistent and easily measured parameter, whereas a spina...

journal_title：Muscle & nerve

authors： Kwast-Rabben O,Libelius R,Heikkilä H

更新日期：2002-10-01 00:00:00

abstract：:In order to further characterize and provide a possible mechanism for the asymmetrical involvement of forearm muscles in inclusion body myositis (IBM), we measured isometric hand and pinch grip strength, and forearm muscle girth on 15 IBM patients. Forearm muscle strength and girth were significantly greater on the do...

journal_title：Muscle & nerve

authors： Felice KJ,Relva GM,Conway SR

更新日期：1998-05-01 00:00:00

abstract：:The objectives of this study were 1) to determine the degree to which soleus motoneurons find their appropriate target following crush and transection injuries to the sciatic nerve, and 2) to determine whether repair of a transected nerve with a silicone tube leads to greater specificity of reinnervation and recovery ...

journal_title：Muscle & nerve

authors： Bodine-Fowler SC,Meyer RS,Moskovitz A,Abrams R,Botte MJ

更新日期：1997-01-01 00:00:00

abstract：:Chronic inflammatory demyelinating polyneuropathy (CIDP) is usually characterized by prominent motor deficits. A pure sensory presentation, labeled chronic sensory demyelinating neuropathy (CSDN), has been reported, but it is unclear if this neuropathy is a distinct clinical and immunologic entity or merely the sensor...

journal_title：Muscle & nerve

authors： Berger AR,Herskovitz S,Kaplan J

更新日期：1995-04-01 00:00:00