Reduced oxidative muscle metabolism in chronic fatigue syndrome.

Abstract:

:The purpose of this study was to determine if chronic fatigue syndrome (CSF) is characterized by abnormalities in oxidative muscle metabolism. Patients with CFS according to Centers for Disease Control (CDC) criteria (n = 22) were compared to normal sedentary subjects (n = 15). CFS patients were also tested before and 2 days after a maximal treadmill test. Muscle oxidative capacity was measured as the maximal rate of postexercise phosphocreatine (PCr) resynthesis using the ADP model (Vmax) in the calf muscles using 31P magnetic resonance spectroscopy. Vmax was significantly reduced in CFS patients (39.6 +/- 2.8 mmol/L/min, mean +/- SE) compared to controls (53.8 +/- 2.8 mmol/L/min). Two days postexercise there was no change in resting inorganic phosphate (Pi)/PCr or Vmax in the CFS patients (n = 14). In conclusion, oxidative metabolism is reduced in CFS patients compared to sedentary controls. In addition, a single bout of strenuous exercise did not cause a further reduction in oxidative metabolism, or alter resting Pi/PCr ratios.

journal_name

Muscle Nerve

journal_title

Muscle & nerve

authors

McCully KK,Natelson BH,Iotti S,Sisto S,Leigh JS Jr

doi

10.1002/(SICI)1097-4598(199605)19:5<621::AID-MUS10

subject

Has Abstract

pub_date

1996-05-01 00:00:00

pages

621-5

issue

5

eissn

0148-639X

issn

1097-4598

pii

10.1002/(SICI)1097-4598(199605)19:5<621::AID-MUS10

journal_volume

19

pub_type

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