Abstract:
INTRODUCTION:Nebulin is a giant actin-binding protein in the thin filament of the skeletal muscle sarcomere. Studies of nebulin interactions are limited by the size, complexity, and poor solubility of the protein. We divided the nebulin super-repeat region into a super-repeat panel, and studied nebulin/actin interactions. METHODS:Actin binding was studied using a co-sedimentation assay with filamentous actin and 26 different nebulin super-repeats. RESULTS:The panel revealed notable differences in actin binding between the super-repeats. Both ends of the super-repeat region bound actin significantly more strongly, whereas the central part of the protein bound actin weakly. Thus, the binding between nebulin and actin formed a location-dependent pattern of strong vs. weak binding. DISCUSSION:The nebulin super-repeat panel allowed us to study the actin binding of each super-repeat individually. The panel will be a powerful tool in elucidating nebulin function in health and disease. Muscle Nerve 59:116-121, 2019.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Laitila J,Lehtonen J,Lehtokari VL,Sagath L,Wallgren-Pettersson C,Grönholm M,Pelin Kdoi
10.1002/mus.26350subject
Has Abstractpub_date
2019-01-01 00:00:00pages
116-121issue
1eissn
0148-639Xissn
1097-4598journal_volume
59pub_type
杂志文章相关文献
MUSCLE & NERVE文献大全abstract::To determine which sensory nerve conduction studies (S-NCS) are helpful in detecting supraclavicular axon loss brachial plexopathies, we selected 53 cases (of 417 reviewed) in whom complicating factors were absent and which, by needle electrode examination findings, involved only a single "truncal" element (upper, mid...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880180813
更新日期:1995-08-01 00:00:00
abstract::A patient in perfect health prior to electrical shock developed an ALS-like syndrome after the shock. Onset of the disease occurred in the limb through which the shock entered, and subsequently followed a course well-described in previous case reports. Possible mechanisms of disease are discussed. ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880141008
更新日期:1991-10-01 00:00:00
abstract::L1 radiculopathy is very rare and difficult to diagnose with needle electromyography. A patient presented with pain and hypesthesia on the anterolateral aspect of the left thigh. Nerve conduction studies and needle electromyography were normal, except for the quadratus lumborum and iliopsoas muscles, which showed abno...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21601
更新日期:2010-04-01 00:00:00
abstract::Adult skeletal muscle fibers are among the few cell types that are truly multinucleated. Recently, evidence has accumulated supporting a role for the modulation of myonuclear number during muscle remodeling in response to injury, adaptation, and disease. These studies have demonstrated that muscle hypertrophy is assoc...
journal_title:Muscle & nerve
pub_type: 杂志文章,评审
doi:10.1002/(sici)1097-4598(199910)22:10<1350::aid-mus
更新日期:1999-10-01 00:00:00
abstract::Single-fiber electromyography (SFEMG) demonstrates abnormal jitter in virtually all (99%) patients with myasthenia gravis (MG). One muscle, the extensor digitorum communis, is abnormal in most patients with this disease, but to obtain the maximum diagnostic sensitivity, it may be necessary to examine other muscles, es...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880090904
更新日期:1986-11-01 00:00:00
abstract::Electrical stimulation was applied daily for 20 minutes to denervated rabbit extensor digitorum longus muscle. One group was stimulated with short tetani, another with 1-Hz frequency, using isometric contractions for both. Tetanic stimulation induced severe fibrosis and is harmful to denervated muscle. One Hertz stimu...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880100206
更新日期:1987-02-01 00:00:00
abstract:INTRODUCTION:Muscle force generation involves recruitment and firing rate modulation of motor units (MUs). The control of MUs in producing multidirectional forces remains unclear. METHODS:We studied MU recruitment and firing properties, recorded from the first dorsal interosseous muscle, for 3 different directions of ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25963
更新日期:2018-01-01 00:00:00
abstract::The physiological and phenotypic properties of motor units in the cat soleus muscle were studied after 4 months of inactivity induced by spinal cord isolation (SI). The soleus of some SI cats were stimulated for 30 min/day during an isometric (SI-I), shortening (SI-S), or lengthening (SI-L) phase of a simulated step c...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.10190
更新日期:2002-08-01 00:00:00
abstract::New developments in the rapid diagnosis and treatment of boys with Duchenne muscular dystrophy (DMD) have led to growing enthusiasm for instituting DMD newborn screening (NBS) in the United States. Our group has been interested in developing clinical guidance to be implemented consistently in specialty care clinics ch...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25185
更新日期:2016-08-01 00:00:00
abstract::Electrodiagnostic findings of fibrillations and positive sharp waves in the lumbosacral paraspinals in patients without previous back surgery has been generally considered to be abnormal, consistent with posterior rami denervation. In some cases, it is the only abnormality on the electromyographic examination. This st...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4598(199603)19:3<350::AID-MUS11
更新日期:1996-03-01 00:00:00
abstract::Myasthenia gravis (MG) and its animal model experimental autoimmune myasthenia gravis (EAMG) are caused by autoantibodies against nicotinic acetylcholine receptor (AChR) in skeletal muscle. The production of anti-AChR antibodies is mediated by cytokines produced by CD4+ and CD8+ T helper (Th) cells. Emerging investiga...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(199705)20:5<543::aid-mus2>
更新日期:1997-05-01 00:00:00
abstract:INTRODUCTION:Widespread musculoskeletal pain is a well-known symptom of myotonic dystrophy type 2 (DM2), but so far it has been addressed in only a few studies. METHODS:A postal survey for all traceable DM2 patients (n = 132) was conducted. A specific questionnaire, and severity and interference subscales of the Brief...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.22249
更新日期:2012-01-01 00:00:00
abstract::Schwartz-Jampel syndrome (SJS) is an autosomal-recessive condition characterized by muscle stiffness and chondrodysplasia. It is due to loss-of-function hypomorphic mutations in the HSPG2 gene that encodes for perlecan, a proteoglycan secreted into the basement membrane. The origin of muscle stiffness in SJS is debate...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21253
更新日期:2009-07-01 00:00:00
abstract:INTRODUCTION:Pompe disease is a progressive and debilitating neuromuscular disorder that presents with a heterogeneous array of signs and symptoms including proximal muscle weakness, respiratory insufficiency, and/or elevated creatine kinase levels. It mimics other neuromuscular disorders, making its diagnosis challeng...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.23643
更新日期:2013-04-01 00:00:00
abstract:INTRODUCTION:Eosinophilic fasciitis (EF) is a rare disorder that can present with muscle symptoms that mimic other neuromuscular diseases. METHODS:We report the case of a 43-year-old woman with chronic muscle aches, tightness, and stiffness with hypertrophied, well-defined muscles despite physical inactivity, and thic...
journal_title:Muscle & nerve
pub_type:
doi:10.1002/mus.25492
更新日期:2017-09-01 00:00:00
abstract::Influenza vaccination has been associated with adverse events including Guillain-Barré syndrome. Because the safety of influenza vaccination in patients with myasthenia gravis (MG) has not been established, some clinicians discourage vaccination for these patients. We explored whether the administration of influenza v...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21440
更新日期:2009-12-01 00:00:00
abstract::We report an 18-month-old Charcot-Marie-Tooth type 1A (CMT1A) patient who developed a rapid-onset neuropathy, with proximal and distal weakness, and non-uniform nerve conduction studies. The neuropathy responded well to immunomodulation, confirming the coexistence of an inherited and an inflammatory neuropathy. Unexpe...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21753
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:This was a multicenter, double-blind, randomized clinical trial to investigate the efficacy of electrical stimulation of denervated muscle (ESDM) on recovery of patients with peripheral nerve injuries. METHODS:We enrolled 38 patients with traumatic peripheral nerve injuries with axonal damage and clinical i...
journal_title:Muscle & nerve
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/mus.26880
更新日期:2020-06-01 00:00:00
abstract::Although conduction block indicates dysfunction of peripheral nerve, it may occur in patients with clinically typical motor neuron disease. There are no universally accepted criteria to identify conduction block, so diagnosis may be difficult. In some peripheral neuropathies, conduction block persists over long period...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880160903
更新日期:1993-09-01 00:00:00
abstract:INTRODUCTION:Full-length tyrosine kinase B (TrkB.FL) and truncated TrkB (TrkB.t1) receptors are colocalized with acetylcholine receptors (AChRs) at the neuromuscular junction. We have recently shown that reduced TrkB expression leads to age-related alterations in AChR structure, neurotransmission failure, and muscle we...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.23616
更新日期:2013-04-01 00:00:00
abstract:INTRODUCTION:Rapid and accessible methods for diagnosing diabetic polyneuropathy (DPN) have been developed, but not validated, in large cohorts of people with diabetes. METHODS:The performance of a point-of-care device (POCD) was studied in 168 patients with type 2 diabetes, estimating the sensitivity, specificity, po...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.26361
更新日期:2019-02-01 00:00:00
abstract::We wished to determine whether evoked force output from a human muscle could be inferred from the amplitude and the frequency of evoked muscular sounds. Sounds from adductor pollicis were recorded with a microphone and compared to evoked force changes produced by varying the intensity of nerve stimulation or of volunt...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(199708)20:8<991::aid-mus9>
更新日期:1997-08-01 00:00:00
abstract::This study contrasts the developmental patterns of expression of 2 subtypes of the voltage-dependent sodium channel in rat muscle that are differentiated by their immunoreactivity with monoclonal antibodies raised to the purified muscle sodium channel protein. One subtype is found in the transverse tubular (T) system ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880140209
更新日期:1991-02-01 00:00:00
abstract::Genetic testing is rapidly becoming an increasingly significant part of the diagnostic armamentarium of neuromuscular clinicians. Although technically easy to order, the results of such testing, whether positive or negative, have potentially enormous consequences for the individual tested and for family members. As a ...
journal_title:Muscle & nerve
pub_type: 杂志文章,评审
doi:10.1002/mus.25400
更新日期:2016-12-01 00:00:00
abstract::Six members originating from two families with hereditary motor and sensory neuropathy (hypertrophic and neuronal types) were noted to have enlarged calf muscles. Muscle computed tomography revealed that muscle enlargement in the propositus of the family with the hypertrophic type of HMSN was due to an increase in mus...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880130109
更新日期:1990-01-01 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a debilitating neurodegenerative disorder with complex biology and significant clinical heterogeneity. Many preclinical and early phase ALS clinical trials have yielded promising results that could not be replicated in larger phase 3 confirmatory trials. One reason for the lack o...
journal_title:Muscle & nerve
pub_type: 杂志文章,评审
doi:10.1002/mus.26801
更新日期:2020-08-01 00:00:00
abstract::Type-specific antibodies to the polymorphic types of collagen have been used to study their distribution in polymyositis. Dramatic increases were observed in the staining with antibodies to Type III collagen and, to a lesser extent, with antibodies to Types I, IV, and V. The changes in capillary and endomysial basemen...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880030605
更新日期:1980-11-01 00:00:00
abstract::The role of motor innervation and muscle tension in the posthatching maturation of the slow-tonic anterior latissimus dorsi (ALD) muscle of the chicken has been investigated. Modification of the muscle tension was obtained either by maintaining ALD in a shortened state or by stretching, after or without denervation. I...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880121112
更新日期:1989-11-01 00:00:00
abstract:INTRODUCTION:Mitochondria are semi-autonomous organelles that are able to change their shape, size, location, and number inside the living cell. Mitochondrial division is an extremely important process, because cell survival depends on there being an adequate number of mitochondria in each cell. The dynamics of these o...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.23365
更新日期:2012-07-01 00:00:00
abstract::Acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) were studied in the diaphragm of early postnatal rats, using radiometric determination of enzyme activities, velocity sedimentation for separation of molecular forms, and electron microscopic cytochemistry to localize enzymes. AChE activity did not change s...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880040607
更新日期:1981-11-01 00:00:00