Abstract:
INTRODUCTION:Pompe disease is a progressive and debilitating neuromuscular disorder that presents with a heterogeneous array of signs and symptoms including proximal muscle weakness, respiratory insufficiency, and/or elevated creatine kinase levels. It mimics other neuromuscular disorders, making its diagnosis challenging and often significantly delayed, thereby increasing morbidity and early mortality of the disease. METHODS:Three Pompe disease patients are discussed to highlight the challenging path to diagnosis and the common cluster of symptoms that could lead to timely and accurate diagnosis. RESULTS:After significant delays in diagnosis, Pompe disease was diagnosed on the basis of the pattern of proximal weakness. CONCLUSIONS:Suspicion and recognition of the characteristic symptoms of Pompe disease may improve both the timing and accuracy of the diagnosis, which will improve clinical outcomes and minimize disease progression.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Dubrovsky A,Corderi J,Karasarides T,Taratuto ALdoi
10.1002/mus.23643subject
Has Abstractpub_date
2013-04-01 00:00:00pages
594-600issue
4eissn
0148-639Xissn
1097-4598journal_volume
47pub_type
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