Abstract:
:Nerve guides seeded with Schwann cells (SCs) promote axonal regeneration in peripheral nerve lesions. We examined the applicability of bioluminescent imaging (BLI) for monitoring the fate of SCs in nerve guides after implantation. Rat SCs were transfected with the firefly luciferase (Fluc) gene and subsequently seeded in nerve guides, which were implanted subcutaneously in rats. In vivo bioluminescence of transfected SCs (Fluc-SCs) was assessed with a BLI system. Scans were validated ex vivo using immunocytochemistry and electron microscopy. We found that BLI enables longitudinal in vivo monitoring of Fluc-SCs, given that proper access of luciferin to the cells is assured.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Ma MS,Van Dam G,Meek M,Boddeke E,Copray Sdoi
10.1002/mus.21372subject
Has Abstractpub_date
2009-11-01 00:00:00pages
867-71issue
5eissn
0148-639Xissn
1097-4598journal_volume
40pub_type
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