Randomized controlled trial of strength training in post-polio patients.

Abstract:

:Many post-polio patients develop new muscle weakness decades after the initial illness. However, its mechanism and treatment are controversial. The purpose of this study was to test the hypotheses that: (1) after strength training, post-polio patients show strength improvement comparable to that seen in the healthy elderly; (2) such training does not have a deleterious effect on motor unit (MU) survival; and (3) part of the strength improvement is due to an increase in voluntary motor drive. After baseline measures including maximum voluntary contraction force, voluntary activation index, motor unit number estimate, and the tetanic tension of the thumb muscles had been determined, 10 post-polio patients with hand involvement were randomized to either the training or control group. The progressive resistance training program consisted of three sets of eight isometric contractions, three times weekly for 12 weeks. Seven healthy elderly were also randomized and trained in a similar manner. Changes in the baseline parameters were monitored once every 4 weeks throughout the training period. The trained post-polio patients showed a significant improvement in their strength (P < 0.05). The magnitude of gain was greater than that seen in the healthy elderly (mean +/- SE, 41 +/- 16% vs. 29 +/- 8%). The training did not adversely affect MU survival and the improvement was largely attributable to an increase in voluntary motor drive. We therefore conclude that moderate intensity strength training is safe and effective in post-polio patients.

journal_name

Muscle Nerve

journal_title

Muscle & nerve

authors

Chan KM,Amirjani N,Sumrain M,Clarke A,Strohschein FJ

doi

10.1002/mus.10327

subject

Has Abstract

pub_date

2003-03-01 00:00:00

pages

332-8

issue

3

eissn

0148-639X

issn

1097-4598

journal_volume

27

pub_type

临床试验,杂志文章,随机对照试验
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    authors: Kazamel M,Klein CJ,Benarroch EE,Patnaik MM,Tracy JA

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  • Electromyographic and lower extremity short time to inversion recovery magnetic resonance imaging findings in lumbar radiculopathy.

    abstract::To determine if short TI (time to inversion) recovery (STIR) magnetic resonance imaging (MRI) is useful in assessing lower extremity (LE) denervation in subacute lumbar radiculopathy (LR), 25 subjects underwent lumbar spine MRI, LE STIR MRI and needle electromyography (EMG). In 23 (92%) subjects there was a positive c...

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    doi:10.1002/(sici)1097-4598(199709)20:9<1191::aid-mus1

    authors: Carter GT,Fritz RC

    更新日期:1997-09-01 00:00:00

  • Effects of exercise and muscle type on BDNF, NT-4/5, and TrKB expression in skeletal muscle.

    abstract::Muscle-derived neurotrophins are thought to contribute to the adaptation of skeletal muscle to exercise, but the effects of brief exercise interventions on BDNF, NT-4/5, and trkB are not understood. RNA was extracted for RT-PCR from soleus and medial gastrocnemius of Sprague-Dawley rats exercised on a treadmill at spe...

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    doi:10.1002/mus.21503

    authors: Ogborn DI,Gardiner PF

    更新日期:2010-03-01 00:00:00

  • Frontal plane ankle proprioceptive thresholds and unipedal balance.

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    doi:10.1002/mus.21194

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  • Contrasting echogenicity in flexor digitorum profundus-flexor carpi ulnaris: a diagnostic ultrasound pattern in sporadic inclusion body myositis.

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    pub_type: 杂志文章

    doi:10.1002/mus.24056

    authors: Noto Y,Shiga K,Tsuji Y,Kondo M,Tokuda T,Mizuno T,Nakagawa M

    更新日期:2014-05-01 00:00:00

  • Time course of axonal regeneration in acute motor axonal neuropathy.

    abstract::Patients with acute motor axonal neuropathy (AMAN) generally recover well. We reviewed clinical and electrophysiologic recovery in 13 patients for up to 5 years. Twelve patients showed rapid recovery over 12 months, whereas in the remaining one the recovery was slow and incomplete at 5 years. In AMAN, axonal degenerat...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.20729

    authors: Tamura N,Kuwabara S,Misawa S,Kanai K,Nakata M,Sawai S,Mori M,Hattori T

    更新日期:2007-06-01 00:00:00

  • Reliability of hand-held dynamometry in spinal muscular atrophy.

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    pub_type: 杂志文章,多中心研究

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    更新日期:2002-07-01 00:00:00

  • Optimal location for eliciting the tibial H-reflex and motor response.

    abstract:INTRODUCTION:Although there are numerous protocols to adjust the amplitude of the Hoffmann reflex (H-reflex) relative to the size of the direct motor response (M-response), the optimal stimulating location has not been described. We sought to determine the optimal positioning of the stimulating cathode when evoking the...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.26308

    authors: Özyurt MG,Shabsog M,Dursun M,Türker KS

    更新日期:2018-12-01 00:00:00

  • A new mutation in the regulatory domain of the myophosphorylase gene affecting protein dimer contact.

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    pub_type: 杂志文章

    doi:10.1002/(sici)1097-4598(199908)22:8<1136::aid-mus2

    authors: Gamez J,Fernandez R,Bruno C,Andreu AL,Cervera C,Navarro C,Schwartz S,Dimauro S

    更新日期:1999-08-01 00:00:00

  • Validation of diagnostic methods for traumatic sensory neuropathy and neuropathic pain.

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    journal_title:Muscle & nerve

    pub_type: 杂志文章

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    authors: Teerijoki-Oksa T,Forssell H,Jääskeläinen SK

    更新日期:2019-03-01 00:00:00

  • Role of nerve and tension in maturation of posthatching slow-tonic muscle in chicken.

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    journal_title:Muscle & nerve

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    doi:10.1002/mus.880121112

    authors: Gardahaut MF,Rouaud TP,Renaud D,Khaskiye A,Le Douarin GH

    更新日期:1989-11-01 00:00:00

  • Intranervous immunoglobulin deposits: an underestimated mechanism of neuropathy.

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    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.21057

    authors: Vallat JM,Magy L,Richard L,Piaser M,Sindou P,Calvo J,Ghorab K,Cros D

    更新日期:2008-07-01 00:00:00

  • Proteasome inhibitors for malignancy-related Lambert-Eaton myasthenic syndrome.

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    pub_type: 杂志文章

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    更新日期:2014-03-01 00:00:00

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    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.22192

    authors: Wong MC,Chung JW

    更新日期:2011-12-01 00:00:00

  • Peptides and neuromas: calcitonin gene-related peptide, substance P, and mast cells in a mechanosensitive human sural neuroma.

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    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-4598(199707)20:7<875::aid-mus12

    authors: Zochodne DW,Theriault M,Sharkey KA,Cheng C,Sutherland G

    更新日期:1997-07-01 00:00:00

  • Stroke-related effects on maximal dynamic hip flexor fatigability and functional implications.

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    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.24520

    authors: Kuhnen HR,Rybar MM,Onushko T,Doyel RE,Hunter SK,Schmit BD,Hyngstrom AS

    更新日期:2015-03-01 00:00:00

  • Clinicopathological and molecular biological studies in a patient with neurolymphomatosis.

    abstract::We describe a patient with a clinical disorder that resembled vasculitic neuropathy in which peripheral nerves were successively affected over several months, but without systemic involvement. An initial muscle biopsy near the involved nerves showed signs of nonspecific inflammation around the muscle and nerve fibers....

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/1097-4598(200010)23:10<1604::aid-mus21>3.0

    authors: Kuntzer T,Lobrinus JA,Janzer RC,Ghika J,Bogousslavsky J

    更新日期:2000-10-01 00:00:00

  • Changes in joint angle, muscle-tendon complex length, muscle contractile tissue displacement, and modulation of EMG activity during acute whole-body vibration.

    abstract::It has been suggested that vibration causes small changes in muscle length, but to the best of our knowledge, these have yet to be demonstrated during whole-body vibration (WBV). This was an observational study to determine whether acute WBV would result in muscle lengthening. We hypothesized that acute WBV would incr...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.21330

    authors: Cochrane DJ,Loram ID,Stannard SR,Rittweger J

    更新日期:2009-09-01 00:00:00

  • The thoracic outlet syndromes.

    abstract::The term thoracic outlet syndrome (TOS) refers to a heterogeneous group of disorders, all of which have in common compression of one or more neurovascular elements at some point within the thoracic outlet. Of the five disorders comprising this group, four have all of the features expected of a syndrome-a recognized co...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,评审

    doi:10.1002/mus.23235

    authors: Ferrante MA

    更新日期:2012-06-01 00:00:00

  • An analysis of disease severity based on SMN2 copy number in adults with spinal muscular atrophy.

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    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.21350

    authors: Elsheikh B,Prior T,Zhang X,Miller R,Kolb SJ,Moore D,Bradley W,Barohn R,Bryan W,Gelinas D,Iannaccone S,Leshner R,Mendell JR,Mendoza M,Russman B,Smith S,King W,Kissel JT

    更新日期:2009-10-01 00:00:00

  • TrkB expression at the neuromuscular junction is reduced during aging.

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    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.23616

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    更新日期:2013-04-01 00:00:00

  • The spread of transgene expression at the site of gene construct injection.

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    pub_type: 杂志文章

    doi:10.1002/mus.1031

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    更新日期:2001-04-01 00:00:00

  • Cross-sectional and longitudinal analysis of an oxidative stress biomarker for spinal and bulbar muscular atrophy.

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    pub_type: 杂志文章

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    更新日期:2012-11-01 00:00:00

  • Skin biopsy in assessing meralgia paresthetica.

    abstract:INTRODUCTION:Meralgia paresthetica is a focal neuropathy caused by compression of the lateral femoral cutaneous nerve (LFCN). The disease can be difficult to assess by neurophysiological or imaging studies. METHODS:We studied 5 patients who presented to our neuromuscular clinic from April 2012 to December 2014 with a ...

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    pub_type: 杂志文章

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    更新日期:2016-04-01 00:00:00

  • Calpain 3 cleaves filamin C and regulates its ability to interact with gamma- and delta-sarcoglycans.

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    pub_type: 杂志文章

    doi:10.1002/mus.10465

    authors: Guyon JR,Kudryashova E,Potts A,Dalkilic I,Brosius MA,Thompson TG,Beckmann JS,Kunkel LM,Spencer MJ

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  • Electrophysiologic assessment of a median nerve injury in the palm.

    abstract::In median nerve lesions of the hand, electrophysiologic evaluation of the second lumbrical muscle can help to differentiate between lesions of the common digital nerves and the proper digital nerves, as illustrated by this case report. Median nerve conduction studies to the second lumbrical muscle can be performed by ...

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  • Effects of insulin on protein synthesis in muscles from normal and dystrophic mice.

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    pub_type: 临床试验,杂志文章,多中心研究

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  • Spinal irradiation does not inhibit distal axonal sprouting.

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