Abstract:
:Reliable unipedal balance is fundamental to safe ambulation. Accordingly, older persons with peripheral neuropathy (PN), who are at increased risk for falls, demonstrate impaired unipedal balance. To explore the relationship between afferent function and unipedal balance, frontal plane proprioceptive thresholds at the ankle were quantified in 22 subjects (72.5 +/- 6.3 years; 11 with PN and 11 matched controls) while they were standing using a foot cradle system and a staircase series of 100 rotational stimuli. PN subjects, as compared to controls, demonstrated shorter median unipedal balance times (3.4 +/- 2.7 vs. 14.3 +/- 8.9 s; P = 0.0017) and greater (less precise) combined ankle inversion/eversion proprioceptive thresholds (1.17 +/- 0.36 vs. 0.65 +/- 0.37 degrees ; P = 0.0055). Combined ankle inversion/eversion proprioceptive thresholds explained approximately half the variance in unipedal balance time (R2 = 0.5138; P = 0.0004). Given prior work demonstrating a similarly strong relationship between ankle torque generation and unipedal balance, neuropathy-associated impairments in ankle frontal plane afferent and efferent function appear to be equally responsible for the inability of older persons with PN to reliably balance on one foot. They therefore provide distinct targets for intervention.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Son J,Ashton-Miller JA,Richardson JKdoi
10.1002/mus.21194subject
Has Abstractpub_date
2009-02-01 00:00:00pages
150-7issue
2eissn
0148-639Xissn
1097-4598journal_volume
39pub_type
杂志文章相关文献
MUSCLE & NERVE文献大全abstract::A previously reported patient presenting sensory-dominant neuropathy with antiganglioside antibodies, bound preferentially to polysialogangliosides including GD1b, was autopsied. While axonal degeneration was predominant in the sural nerve, many demyelinated fibers were present in the spinal roots. Dorsal roots had un...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(199910)22:10<1426::aid-mus
更新日期:1999-10-01 00:00:00
abstract::Chronic and acute administration of epinephrine or related sympathomimetic agents are typically prescribed for the treatment of clinical disorders such as hypotension, anaphylactic and allergic reactions, and bronchial asthma. In addition to its effects on these infirmaties and on carbohydrate metabolism, epinephrine ...
journal_title:Muscle & nerve
pub_type: 杂志文章,评审
doi:10.1002/mus.880121204
更新日期:1989-12-01 00:00:00
abstract::Mutations in the myelin protein zero gene (MPZ) are associated with certain demyelinating neuropathies, and in particular with Charcot-Marie-Tooth disease type 1B (CMT1B), Dejerine-Sottas syndrome, and congenital hypomyelination. MPZ mutations affecting the protein's transmembrane domain are generally associated with ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.20034
更新日期:2004-06-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to examine the coping strategies of 49 patients with amyotrophic lateral sclerosis (ALS) and the relationships of these strategies to their perceived health-related quality of life (HRQoL). METHODS:Forty-nine subjects were assessed for collection of demographic and medical data. ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.22270
更新日期:2012-01-01 00:00:00
abstract::The American Association of Neuromuscular & Electrodiagnostic Medicine (AANEM) developed guidelines to formalize the ethical standards that neuromuscular and electrodiagnostic (EDx) physicians should observe in their clinical and scientific activities. Neuromuscular and EDx medicine is a subspecialty of medicine that ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.24910
更新日期:2015-12-01 00:00:00
abstract::This study contrasts the developmental patterns of expression of 2 subtypes of the voltage-dependent sodium channel in rat muscle that are differentiated by their immunoreactivity with monoclonal antibodies raised to the purified muscle sodium channel protein. One subtype is found in the transverse tubular (T) system ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880140209
更新日期:1991-02-01 00:00:00
abstract::Genetically homozygous line 413 dystrophic chickens were given twice-daily intraperitoneal injections of solutions containing branched-chain amino acids (BCCA-leucine, valine, isoleucine) either alone or in combination; and their alpha-ketoacid analogs (alpha-ketoisocaproic and alpha-ketoisovaleric acids). Another tri...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880050606
更新日期:1982-07-01 00:00:00
abstract::Electromyographic examination of the deeper external anal sphincter (EAS) muscle is far more uncomfortable than of the subcutaneous muscle, so we tested the need for its examination. We compared the findings in 85 paired examinations of ipsilateral subcutaneous and deeper EAS muscles in 67 patients with a cauda equina...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.10417
更新日期:2003-09-01 00:00:00
abstract::A low conductance calcium-activated K+ channel is thought to regulate the rate of firing of several excitable cells. In skeletal muscle the expression of this channel is under nerve control. Previously, we reported that axonal flow blockade of rat nerves, induced by colchicine, caused a transient increase in muscle ap...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880160908
更新日期:1993-09-01 00:00:00
abstract:INTRODUCTION:Neutral lipid-storage disease with myopathy is caused by mutations in PNPLA2, which produce skeletal and cardiac myopathy. We report a man with multiorgan neutral lipid storage and unusual multisystem clinical involvement, including cognitive impairment. METHODS:Quantitative brain MRI with voxel-based mor...
journal_title:Muscle & nerve
pub_type: 杂志文章,评审
doi:10.1002/mus.24983
更新日期:2016-04-01 00:00:00
abstract::Frog muscles bathed in solutions equilibrated with 0.5%-2.0% halothane develop large contractures when cooled to 2-4 degrees C. These halothane-cooling contractures (HCC) are dose dependent and reproducible; they are potentiated by lidocaine (5 mM), abolished by procaine (5 mM), and partially inhibited by procainamide...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880090107
更新日期:1986-01-01 00:00:00
abstract::Morphological changes of the subneural apparatus (SNA) during denervation and reinnervation are demonstrated using the hamster peroneus longus muscle. One week after nerve section, synaptic grooves (SGs) were more shallow, with lowered sarcoplasmic ridges. After 4 weeks, the whole SNA area was elevated above the sarco...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880111211
更新日期:1988-12-01 00:00:00
abstract::Twenty patients with myasthenia gravis were studied. Needle interference patterns at maximal isometric contractions were recorded from the biceps brachii muscles. Each recording lasted for 30 seconds and induced some fatigue. The EMG signals were transformed into power spectra and were analyzed for differences between...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880080410
更新日期:1985-05-01 00:00:00
abstract::The fastest median and ulnar velocities derived by recording motor and mixed nerve action potentials, F waves, H-reflexes, and somatosensory evoked potentials (SEPs) were compared. H-reflex recording was facilitated by employing selective group Ia excitation during voluntary muscular contraction. Mixed nerve, SEP, and...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880070807
更新日期:1984-10-01 00:00:00
abstract:INTRODUCTION:Neuromuscular activation can be influenced by both muscle temperature (Tm) and fatigue. METHODS:To assess the effects of Tm and fatigue on the electromechanical delay (EMD), 15 participants performed voluntary isometric contractions of different intensities under neutral (TmN), low (TmL), and high (TmH) T...
journal_title:Muscle & nerve
pub_type: 杂志文章,随机对照试验
doi:10.1002/mus.23627
更新日期:2013-04-01 00:00:00
abstract::As caveolin-3 deficiencies may explain persistent hyper-CK-emia, we performed CAV3 gene mutation analysis and immunohistochemistry for caveolin-3 in 31 patients with idiopathic hyper-CK-emia. In 2 of 29 patients who donated blood, variants in the CAV3 gene were detected. Although immunohistochemical analysis strongly ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.20593
更新日期:2006-11-01 00:00:00
abstract:INTRODUCTION:Muscle fatigue could have a greater impact on position sense when antagonists of the movement are fatigued. Hence, this study aimed to compare the effects of antagonist and agonist exercise-induced muscle fatigue on knee joint position sense. METHODS:This within-subjects repeated-measures study included 4...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.22018
更新日期:2011-08-01 00:00:00
abstract::Phospholipid methylation is thought to modulate such vital cellular processes as calcium transport, receptor function, and membrane microviscosity. As these processes are fundamental to the function of muscle cells and are thought to be altered in disease states, we have characterized several features of phospholipid ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880080513
更新日期:1985-06-01 00:00:00
abstract::Morvan's syndrome is a rare disorder characterized by neuromyotonia, hyperhidrosis, and central nervous system dysfunction. We report a patient with features of this syndrome, but who initially presented with breathing difficulties. Concentric needle electromyography showed an abundance of myokymic and neuromyotonic d...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.20081
更新日期:2004-08-01 00:00:00
abstract::Techniques to estimate motor unit number (MUNE) measure the number of functioning motor units in a muscle. As amyotrophic lateral sclerosis (ALS) is characterized by progressive motor unit loss, this disease offers an ideal setting for the use of MUNE. Statistical MUNE was employed in a recent multicenter trial of cre...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.20671
更新日期:2007-02-01 00:00:00
abstract:INTRODUCTION:Muscle fiber denervation increases with age, yet studies at the tissue level are sparse due to the challenging nature of establishing the relative role of regeneration and denervation. METHODS:Muscle biopsies were obtained from the vastus lateralis of 70 healthy men (aged 72 ± 6 years; range, 65-94). Mess...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.26638
更新日期:2019-10-01 00:00:00
abstract::To define numerically the clinical severity of facioscapulohumeral muscular dystrophy (FSHD), we developed a protocol that quantifies muscle weakness by combining the functional evaluation of six muscle groups affected in this disease. To validate reproducibility of the protocol, 69 patients were recruited. Each patie...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21671
更新日期:2010-08-01 00:00:00
abstract::Data are scarce relating to the plasticity with strength training of dynamic muscle performance in older humans. Hence, we investigated alterations in the torque-velocity relation with strength training in old age, and their origin. Knee extension and leg-press exercises were performed three times per week for 14 week...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.20275
更新日期:2005-03-01 00:00:00
abstract::Comparison was made between simultaneous recordings of the electromyogram (EMG) and acoustic myogram (AMG) signals and the torque produced by the lumbar erectores spinae muscles of three healthy subjects while they performed isometric contractions. Repeatability of each signal was studied. The AMG had a relationship t...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880110409
更新日期:1988-04-01 00:00:00
abstract::Patients with prior poliomyelitis may experience muscle function deterioration decades after onset of disease. The present study is aimed at describing electromyographic and morphometric evidence of muscular compensation and of on-going muscular instability. Ten subjects 42-62 years of age with onset of polio 25-52 ye...
journal_title:Muscle & nerve
pub_type: 临床试验,杂志文章
doi:10.1002/mus.880130214
更新日期:1990-02-01 00:00:00
abstract::Three cases of chronic distal sensorimotor neuropathy are described in patients with neurofibromatosis. One had type 2 or central neurofibromatosis with a chromosome 22 deletion; the precise form of the disease was not established in the other two. A striking clinical feature was a diffuse nodular enlargement of the p...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880130202
更新日期:1990-02-01 00:00:00
abstract:INTRODUCTION:In this study, we questioned whether local cooling of muscle or heating involving core and muscle temperatures are the main indicators for force variability. METHODS:Ten volunteers performed a 2-min maximum voluntary contraction (MVC) of the knee extensors under control (CON) conditions after passive heat...
journal_title:Muscle & nerve
pub_type: 杂志文章,随机对照试验
doi:10.1002/mus.23397
更新日期:2012-11-01 00:00:00
abstract::We investigated whether the modulatory effects of segmental and descending inputs on the soleus H reflex are modified by postural conditions. Fourteen healthy volunteers received a transcranial magnetic stimulus (TMS) or percutaneous electrical stimulation of the posterior tibial nerve (PTN), preceding by 0 to 400 ms ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(200006)23:6<925::aid-mus13
更新日期:2000-06-01 00:00:00
abstract::Recent studies on the distribution of labeled endogenous proteins in the experimental neuropathies induced by streoptozotocin diabetes, galactose feeding, zinc pyridinethione, 2,5-hexanedione, acrylamide, and p-bromophenylacetylurea (BPAU) have demonstrated an impaired build up of retrogradely transported material der...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880060214
更新日期:1983-02-01 00:00:00
abstract:INTRODUCTION:Two previously reported Norwegian patients with painful muscle cramps and giant myotonic discharges were genotyped and compared with those of members of 21 families harboring the same mutation. METHODS:Using primers specific for SCN4A and CLCN1, the DNA of the Norwegian family members was amplified and bi...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.24672
更新日期:2015-10-01 00:00:00