Abstract:
:We have identified a novel missense mutation in the myophosphorylase gene in a Spanish patient with McArdle's disease. The patient was homozygous for a T-to-C transition at codon 115 (L115P) in exon 3, which changed an encoded leucine (CUG) to a proline (CCG). This is the first mutation to be described in exon 3 and in a protein domain related to dimer contact. These data further emphasize the importance of private mutations in McArdle's disease, some of which are associated with specific ethnic groups.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Gamez J,Fernandez R,Bruno C,Andreu AL,Cervera C,Navarro C,Schwartz S,Dimauro Sdoi
10.1002/(sici)1097-4598(199908)22:8<1136::aid-mus2subject
Has Abstractpub_date
1999-08-01 00:00:00pages
1136-8issue
8eissn
0148-639Xissn
1097-4598pii
10.1002/(SICI)1097-4598(199908)22:8<1136::AID-MUS2journal_volume
22pub_type
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