Muscle changes in patients with diabetes and chronic exertional compartment syndrome before and after treatment with fasciotomy.

Abstract:

INTRODUCTION:Muscle changes in patients with diabetes and lower leg pain due to chronic exertional compartment syndrome (CECS) were investigated before and after fasciotomy. METHODS:The tibialis anterior muscle was analyzed with histochemical and morphological techniques in 7 patients with diabetes and CECS before fasciotomy and in 5 of them 1 year after fasciotomy. Nondiabetic patients with CECS and healthy participants served as references. RESULTS:Before treatment, walking distance until occurrence of pain was limited (<0.2 km). Intramuscular pressure was significantly higher than in reference participants. Muscle analysis showed changes pathognomonic for neuropathy and myopathy and a restricted capillary network, with significantly more severe changes in the muscles of patients with diabetes than in the muscles of nondiabetic patients. Treatment with fasciotomy improved clinical signs, increased walking ability, and reduced muscle abnormalities, but muscle capillarization remained low. DISCUSSION:Patients with diabetes and CECS have distinct pathological changes in affected muscles. Pressure-relieving fasciotomy triggers a regenerative response in the muscle tissue but not in the capillary bed. Muscle Nerve 57: 229-239, 2018.

journal_name

Muscle Nerve

journal_title

Muscle & nerve

authors

Edmundsson DS,Toolanen GL,Stål PS

doi

10.1002/mus.25715

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

229-239

issue

2

eissn

0148-639X

issn

1097-4598

journal_volume

57

pub_type

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