Postexercise phosphocreatine resynthesis is slowed in multiple sclerosis.

Abstract:

:To determine whether skeletal muscle oxidative metabolism is impaired in multiple sclerosis (MS), phosphorus magnetic resonance spectroscopy was used to measure the rate of intramuscular phosphocreatine (PCr) resynthesis following exercise in MS and controls. Thirteen MS patients underwent intermittent isometric tetanic contractions of the dorsiflexor muscles elicited by stimulation of the peroneal nerve. Eight healthy control subjects performed voluntary isometric exercise of the same muscles. During exercise, there were no differences between groups in the fall of either PCr or pH. However, the half-time (T1/2) of PCr recovery following exercise was significantly longer in MS (2.3 +/- 0.3 min) compared to controls (1.2 +/- 0.1 min, P < 0.02). These data provide evidence of slowed PCr resynthesis following exercise in MS, which indicates impaired oxidative capacity in the skeletal muscle of this group. This finding suggests that intramuscular changes consistent with deconditioning may be important in the altered muscle function of persons with MS.

journal_name

Muscle Nerve

journal_title

Muscle & nerve

authors

Kent-Braun JA,Sharma KR,Miller RG,Weiner MW

doi

10.1002/mus.880170802

subject

Has Abstract

pub_date

1994-08-01 00:00:00

pages

835-41

issue

8

eissn

0148-639X

issn

1097-4598

journal_volume

17

pub_type

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