Iron load and redox stress in skeletal muscle of aged rats.

abstract：:Forty patients with polymyositis or dermatomyositis underwent detailed electromyographic evaluation. The paraspinal muscles of all patients were examined, as were several extremity muscles. The distribution of fibrillation potentials (FPs) in different muscles is discussed. FPs were most frequent in paraspinal muscles...

journal_title：Muscle & nerve

authors： Streib EW,Wilbourn AJ,Mitsumoto H

更新日期：1979-01-01 00:00:00

abstract：INTRODUCTION:Weakness in patients with chronic inflammatory demyelinating polyneuropathy (CIDP) may be caused by decreases in muscle quantity and quality, but this has not been explored. METHODS:Twelve patients with CIDP (mean age 61 years) and 10 age-matched (mean age 59 years) control subjects were assessed for ankl...

journal_title：Muscle & nerve

authors： Gilmore KJ,Doherty TJ,Kimpinski K,Rice CL

更新日期：2018-09-01 00:00:00

abstract：:Skeletal muscle fibers from dystrophic mice and littermate controls (ReJ-129) were characterized electrically and then injected with an intracellular marker. In this way they could be identified for examination with an electron microscope to correlate the relative time course of electrical and ultrastructural alterati...

journal_title：Muscle & nerve

authors： Kerr LM,Sperelakis N

更新日期：1983-01-01 00:00:00

abstract：INTRODUCTION:RASopathies are a group of genetic conditions due to alterations of the Ras/MAPK pathway. Neurocutaneous findings are hallmark features of the RASopathies, but musculoskeletal abnormalities are also frequent. The objective was to evaluate handgrip strength in the RASopathies. METHODS:Individuals with RASo...

journal_title：Muscle & nerve

authors： Stevenson DA,Allen S,Tidyman WE,Carey JC,Viskochil DH,Stevens A,Hanson H,Sheng X,Thompson BA,Okumura MJ,Reinker K,Johnson B,Rauen KA

更新日期：2012-09-01 00:00:00

abstract：:The aim of this work was to determine the role of peripheral facial muscle reinnervation in the central reorganization of the blink reflex (BR) after hypoglossal-facial anastomosis (HFA). An electrophysiological study was performed on seven patients who underwent HFA after facial nerve transection during surgery for a...

journal_title：Muscle & nerve

authors： Bernat I,Vitte E,Lamas G,Soudant J,Willer JC,Tankéré F

更新日期：2006-03-01 00:00:00

abstract：:The sternocleidomastoid muscle (SCM) is one of the major muscles involved in producing abnormal head position in cervical dystonia patients. This study tested whether doxorubicin chemomyectomy, direct injection of doxorubicin into the SCM to permanently remove muscle fibers, has the potential to be a nonsurgical, perm...

journal_title：Muscle & nerve

authors： McLoon LK,Falkenberg JH,Dykstra D,Iaizzo PA

更新日期：1998-11-01 00:00:00

abstract：INTRODUCTION:An enlarged tongue (macroglossia) has been reported in advanced-stage patients with amyotrophic lateral sclerosis (ALS). METHODS:In this study we examined the prevalence of macroglossia and analyzed clinical correlations in 65 ALS patients on tracheostomy-invasive ventilation (TIV). RESULTS:Macroglossia ...

journal_title：Muscle & nerve

authors： Matsuda C,Shimizu T,Nakayama Y,Haraguchi M,Hakuta C,Itagaki Y,Ogura A,Murata K,Taira M,Numayama T,Kinoshita M

更新日期：2016-09-01 00:00:00

abstract：:Muscle-derived neurotrophins are thought to contribute to the adaptation of skeletal muscle to exercise, but the effects of brief exercise interventions on BDNF, NT-4/5, and trkB are not understood. RNA was extracted for RT-PCR from soleus and medial gastrocnemius of Sprague-Dawley rats exercised on a treadmill at spe...

journal_title：Muscle & nerve

authors： Ogborn DI,Gardiner PF

更新日期：2010-03-01 00:00:00

abstract：INTRODUCTION:Anecdotal reports from families and care providers suggest a wide variation in services received by individuals with Duchenne/Becker muscular dystrophy (DBMD). METHODS:We documented the type and frequency of health services received by individuals with DBMD using the Muscular Dystrophy Surveillance Tracki...

journal_title：Muscle & nerve

authors： Pandya SK,Campbell KA,Andrews JG,Meaney FJ,Ciafaloni E

更新日期：2016-02-01 00:00:00

abstract：:This longitudinal study of 194 patients with sporadic ALS demonstrated that it is possible for physicians to predict the approximate survival time for an individual ALS patient given: (1) the age of the patient, (2) the duration of his weakness and (3) an estimate of his clinical disability (ALS Score). This informati...

journal_title：Muscle & nerve

authors： Jablecki CK,Berry C,Leach J

更新日期：1989-10-01 00:00:00

abstract：:The absolute number of satellite cells (SC) in young and adult rat skeletal muscle was estimated by correlating data from light and electron microscopic quantitation of myofiber nuclei (myonuclei and satellite cell nuclei) with biochemical assays for determining total muscle DNA content. Expressed both as a proportion...

journal_title：Muscle & nerve

authors： Gibson MC,Schultz E

更新日期：1983-10-01 00:00:00

abstract：INTRODUCTION:Acetylcholine receptor (AChR) and striated muscle antibodies (StrAbs) are found frequently in myasthenia gravis (MG) patients with thymoma. In this study we aimed to determine the positive predictive value (PPV) and negative predictive value (NPV) of these antibodies for thymoma in patients with MG. METHO...

journal_title：Muscle & nerve

authors： Choi Decroos E,Hobson-Webb LD,Juel VC,Massey JM,Sanders DB

更新日期：2014-01-01 00:00:00

abstract：:Based on the known trophic effects of growth hormone (GH) on nerve and muscle 75 patients with ALS were treated for up to 18 months with synthetic human growth hormone (Protropin) or a placebo. The course of ALS was assessed serially using a quantitative (TQNE) neuromuscular and manual exam (MRC) and laboratory chemis...

journal_title：Muscle & nerve

authors： Smith RA,Melmed S,Sherman B,Frane J,Munsat TL,Festoff BW

更新日期：1993-06-01 00:00:00

abstract：:Autosomal dominant oculopharyngeal muscular dystrophy (OPMD) is an adult-onset disease caused by (GCG) repeat expansions in exon 1 of the poly(A) binding protein 2 gene (PABP2). To elucidate the molecular mechanism underlying the disease, we raised an antiserum against a synthetic peptide fragment predicted from PABP2...

journal_title：Muscle & nerve

authors： Uyama E,Tsukahara T,Goto K,Kurano Y,Ogawa M,Kim YJ,Uchino M,Arahata K

更新日期：2000-10-01 00:00:00

abstract：:The distribution of collagen types I, III, and V and fibronectin was investigated by means of immunofluorescent techniques in denervated and normal rat skeletal muscle. During a period of 28 days, a distinct atrophy developed in the denervated gastrocnemius muscle and was accompanied by an increase in types I and III ...

journal_title：Muscle & nerve

authors： Salonen V,Lehto M,Kalimo M,Penttinen R,Aro H

更新日期：1985-02-01 00:00:00

abstract：:Epidemiological data suggest that prolonged exposure to cyclic lumbar flexion elicits a chronic neuromuscular disorder and disability in workers. This study provides a physiological and biomechanical assessment of various repetitions of cyclic lumbar flexion sessions as a risk factor for development of an acute neurom...

journal_title：Muscle & nerve

authors： Navar D,Zhou BH,Lu Y,Solomonow M

更新日期：2006-11-01 00:00:00

abstract：:Genetic testing is rapidly becoming an increasingly significant part of the diagnostic armamentarium of neuromuscular clinicians. Although technically easy to order, the results of such testing, whether positive or negative, have potentially enormous consequences for the individual tested and for family members. As a ...

journal_title：Muscle & nerve

authors： Su X,Kang PB,Russell JA,Simmons Z

更新日期：2016-12-01 00:00:00

abstract：:Heterozygous mutations in the Berardinelli-Seip congenital lipodystrophy (BSCL2) gene have been associated with different clinical phenotypes including Silver syndrome/spastic paraplegia 17, distal hereditary motor neuropathy type V, and Charcot-Marie-Tooth disease type 2 (CMT2) with predominant hand involvement. We s...

journal_title：Muscle & nerve

authors： Luigetti M,Fabrizi GM,Madia F,Ferrarini M,Conte A,Delgrande A,Tonali PA,Sabatelli M

更新日期：2010-09-01 00:00:00

abstract：:In anterior interosseous nerve syndrome and ulnar neuropathy, paralysis or weakness of the flexor digitorum profundus (FDP) muscles has been shown to vary according to the degree of involvement of the median and ulnar nerves, respectively. We traced these nerves in 50 cadaveric specimens in which each FDP was complete...

journal_title：Muscle & nerve

authors： Oh CS,Won HS,Lee KS,Chung IH,Kim SM

更新日期：2009-04-01 00:00:00

abstract：:An enzyme- and immunohistochemical study has been performed on human masseter muscle spindles. Antibodies selective for different myosin heavy chain (MHC) isoforms and M-band proteins (M-protein, myomesin, and MM-CK) were used. The expression of these proteins was determined in the different intrafusal fiber types. Nu...

journal_title：Muscle & nerve

authors： Eriksson PO,Butler-Browne GS,Thornell LE

更新日期：1994-01-01 00:00:00

abstract：:High-dose immunoglobulins for intravenous administration (IVIg) have originally been developed for substitution therapy in hypogammaglobulinemia. Over the last decade they are increasingly used in the treatment of immune-mediated diseases. In this review the results in immune-mediated neuromuscular diseases are summar...

journal_title：Muscle & nerve

authors： van der Meché FG,van Doorn PA

更新日期：1997-02-01 00:00:00

abstract：:A careful monitoring of the accuracy of diagnosis in six cases of Guillain-Barre syndrome has shown that a substantial proportion of these patients initially diagnosed as having Guillain-Barre syndrome on the basis of characteristic clinical findings and an elevated level of protein in the spinal fluid had a neuropath...

journal_title：Muscle & nerve

authors： Feit H,Tindall RS,Glasberg M

更新日期：1982-02-01 00:00:00

abstract：:In a woman with a slowly progressive adult onset proximal myopathy, muscle biopsy showed storage of PAS positive material in type 1 fibers. This material consisted of a branched chain polysaccharide associated with a mucoprotein. No abnormality of glycogen-pathway enzymes was detected. This suggested that this polysac...

journal_title：Muscle & nerve

authors： Thompson AJ,Swash M,Cox EL,Ingram DA,Gray A,Schwartz MS

更新日期：1988-04-01 00:00:00

abstract：:Sucrose gap and intra-axonal recording techniques were used to identify the types of ion channels and inward rectification that are present in regenerated axons of adult (greater than 8 weeks) rat sciatic nerve after crush injury. In sucrose gap recordings, 4-aminopyridine (4-AP) led to slight broadening of the compou...

journal_title：Muscle & nerve

authors： Gordon TR,Kocsis JD,Waxman SG

更新日期：1991-07-01 00:00:00

abstract：:Neurotrophic factors are growth factors or cytokines that are inducible polypeptides and permit intercellular communication. An explosion of information about neurotrophic factors is setting the stage for significant advances in neural disease therapy in the next century. The effects of these trophic factors are overl...

journal_title：Muscle & nerve

authors： Mitsumoto H,Tsuzaka K

更新日期：1999-08-01 00:00:00

abstract：INTRODUCTION:The risk of cancer in patients diagnosed with myotonic dystrophy (DM) is reported for the homogeneous Utah population. METHODS:Clinical data accessed from the largest Utah healthcare providers have been record-linked to the Utah Population Database, a population-based resource also linked to the Utah Canc...

journal_title：Muscle & nerve

authors： Abbott D,Johnson NE,Cannon-Albright LA

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Anti-cytosolic 5'-nucleotidase 1A (cN1A) antibodies are commonly detected in patients with sporadic inclusion body myositis (sIBM). However, their pathogenic role has not been established. Moreover, efforts toward identifying sIBM distinct clinicopathologic characteristics associated with these antibodies ha...

journal_title：Muscle & nerve

authors： Paul P,Liewluck T,Ernste FC,Mandrekar J,Milone M

更新日期：2020-12-29 00:00:00

abstract：INTRODUCTION:We determined whether instrumenting timed functional tasks with wireless inertial motion sensors were responsive to facioscapulohumeral muscular dystrophy (FSHD) progression and movement pattern changes. METHODS:Ten individuals who were clinically affected with genetically confirmed FSHD, mean age 54 year...

journal_title：Muscle & nerve

authors： Statland JM,Karanevich A,Bruetsch A,Huisinga J

更新日期：2019-11-01 00:00:00

abstract：:The inflammatory myopathies include dermatomyositis (DM), polymyositis (PM), and sporadic inclusion-body myositis (s-IBM). In DM, the main immune effector response appears to be humoral and directed against the microvasculature, whereas in both PM and s-IBM, cytotoxic CD8+ T cells and macrophages invade and eventually...

journal_title：Muscle & nerve

authors： Figarella-Branger D,Civatte M,Bartoli C,Pellissier JF

更新日期：2003-12-01 00:00:00

abstract：:Previous studies suggest that the muscle fiber lysosome system plays a central role in the increased formation of autophagosomes and autolysosomes that occurs in the context of chloroquine-induced myopathy. The goal of this study was to characterize the contribution of receptor-mediated intracellular transport, partic...

journal_title：Muscle & nerve

authors： Masuda T,Ueyama H,Nakamura K,Jikumaru M,Toyoshima I,Kumamoto T

更新日期：2005-04-01 00:00:00