Reductions in muscle quality and quantity in chronic inflammatory demyelinating polyneuropathy patients assessed by magnetic resonance imaging.


INTRODUCTION:Weakness in patients with chronic inflammatory demyelinating polyneuropathy (CIDP) may be caused by decreases in muscle quantity and quality, but this has not been explored. METHODS:Twelve patients with CIDP (mean age 61 years) and 10 age-matched (mean age 59 years) control subjects were assessed for ankle dorsiflexion strength, and two different MRI scans (T1 and T2) of leg musculature. RESULTS:Isometric strength was 36% lower in CIDP patients compared with controls. Tibialis anterior muscle volumes of CIDP patients were smaller by ∼17% compared with controls, and non-contractile tissue volume was ∼58% greater in CIDP patients. When normalized to total muscle or corrected contractile volume, strength was ∼29% and ∼18% lower, respectively, in CIDP patients. DISCUSSION:These results provide insight into the structural integrity of muscle contractile proteins and pathologic changes to whole-muscle tissue composition that contribute to impaired muscle function in CIDP. Muscle Nerve 58: 396-401, 2018.


Muscle Nerve


Muscle & nerve


Gilmore KJ,Doherty TJ,Kimpinski K,Rice CL




Has Abstract


2018-09-01 00:00:00












  • L1 radiculopathy mimicking meralgia paresthetica: a case report.

    abstract::L1 radiculopathy is very rare and difficult to diagnose with needle electromyography. A patient presented with pain and hypesthesia on the anterolateral aspect of the left thigh. Nerve conduction studies and needle electromyography were normal, except for the quadratus lumborum and iliopsoas muscles, which showed abno...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Yang SN,Kim DH

    更新日期:2010-04-01 00:00:00

  • Medial femoral cutaneous nerve conduction study with distal recording: A novel technique.

    abstract:BACKGROUND:A new technique to obtain the sensory nerve action potential (SNAP) of the medial femoral cutaneous nerve is described. METHODS:SNAPs were recorded from 104 subjects with a bar recording electrode 10 cm proximal to the patella along an imaginary line drawn between the medial edge of the patella and the femo...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Geney-Castro DE,Vanegas-Muñóz J,Plata-Contreras J,Salinas-Duran F

    更新日期:2020-03-01 00:00:00

  • Adipose stem cells enhance myoblast proliferation via acetylcholine and extracellular signal-regulated kinase 1/2 signaling.

    abstract:INTRODUCTION:In this study we investigated the interaction between adipose tissue-derived stem cells (ASCs) and myoblasts in co-culture experiments. METHODS:Specific inductive media were used to differentiate ASCs in vitro into a Schwann cell-like phenotype (differentiated adipose tissue-derived stem cells, or dASCs) ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: El-Habta R,Kingham PJ,Backman LJ

    更新日期:2018-02-01 00:00:00

  • A freeze-fracture analysis of intramembrane particle densities on dystrophic hamster heart sarcolemma.

    abstract::The intramembrane particle (IMP) profile of control and dystrophic (Bio 14.6) hamster cardiac muscle plasma membrane was assessed in freeze-fracture replicas to determine whether this animal model of muscular dystrophy exhibits the same membrane characteristics found in skeletal muscle from other more thoroughly studi...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Graham KA,Shivers RR,Atkinson BG

    更新日期:1984-09-01 00:00:00

  • Peripheral muscle weakness in RASopathies.

    abstract:INTRODUCTION:RASopathies are a group of genetic conditions due to alterations of the Ras/MAPK pathway. Neurocutaneous findings are hallmark features of the RASopathies, but musculoskeletal abnormalities are also frequent. The objective was to evaluate handgrip strength in the RASopathies. METHODS:Individuals with RASo...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Stevenson DA,Allen S,Tidyman WE,Carey JC,Viskochil DH,Stevens A,Hanson H,Sheng X,Thompson BA,Okumura MJ,Reinker K,Johnson B,Rauen KA

    更新日期:2012-09-01 00:00:00

  • Effects of temperature and fatigue on the electromechanical delay components.

    abstract:INTRODUCTION:Neuromuscular activation can be influenced by both muscle temperature (Tm) and fatigue. METHODS:To assess the effects of Tm and fatigue on the electromechanical delay (EMD), 15 participants performed voluntary isometric contractions of different intensities under neutral (TmN), low (TmL), and high (TmH) T...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,随机对照试验


    authors: Cè E,Rampichini S,Agnello L,Limonta E,Veicsteinas A,Esposito F

    更新日期:2013-04-01 00:00:00

  • Muscle-fiber apoptosis in neuromuscular diseases.

    abstract::Muscle-fiber loss is a characteristic of many progressive neuromuscular disorders. Over the past decade, identification of a growing number of apoptosis-associated factors and events in pathological skeletal muscle provided increasing evidence that apoptotic cell-death mechanisms account significantly for muscle-fiber...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,评审


    authors: Tews DS

    更新日期:2005-10-01 00:00:00

  • Differences between young and older women in maximal force, force fluctuations, and surface EMG during isometric knee extension and elbow flexion.

    abstract::The loss of muscle strength with aging appears to be greater in the lower than upper limbs, but strength and its neural control have never been compared in the same population of individuals in both upper and lower limbs. The aim of this study was to investigate differences between eight young (20-31 years) and eight ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Bazzucchi I,Felici F,Macaluso A,De Vito G

    更新日期:2004-11-01 00:00:00

  • Red blood cell alterations in muscular dystrophy: the role of lipids.

    abstract::Biochemical, morphologic, and biophysical studies support the concept that the red blood cell (RBC) membrane is altered in both myotonic muscular dystrophy (MyD) and Duchenne muscular dystrophy (DMD). These studies have not identified a primary metabolic defect that would explain the various alterations of membrane pr...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,评审


    authors: Plishker GA,Appel SH

    更新日期:1980-01-01 00:00:00

  • Correlating serum micrornas and clinical parameters in amyotrophic lateral sclerosis.

    abstract:INTRODUCTION:Amyotrophic lateral sclerosis (ALS) is a debilitating neurologic disorder with poor survival rates and no clear biomarkers for disease diagnosis and prognosis. METHODS:We compared serum microRNA (miRNA) expression from patients with ALS with healthy controls and patients with multiple sclerosis and Alzhei...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Raheja R,Regev K,Healy BC,Mazzola MA,Beynon V,Von Glehn F,Paul A,Diaz-Cruz C,Gholipour T,Glanz BI,Kivisakk P,Chitnis T,Weiner HL,Berry JD,Gandhi R

    更新日期:2018-08-01 00:00:00

  • M wave changes with temperature in amyotrophic lateral sclerosis and disorders of neuromuscular transmission.

    abstract::Local cooling of the muscle resulted in significant increases in M wave surface areas in patients with ALS, myasthenia gravis, the Lambert-Eaton myasthenic syndrome, and also in controls. The most striking increases were seen in patients with early ALS who had minimal lower motor neuron involvement and/or little defec...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Denys EH

    更新日期:1990-07-01 00:00:00

  • The effect of temperature on amount and structure of motor variability during 2-minute maximum voluntary contraction.

    abstract:INTRODUCTION:In this study, we questioned whether local cooling of muscle or heating involving core and muscle temperatures are the main indicators for force variability. METHODS:Ten volunteers performed a 2-min maximum voluntary contraction (MVC) of the knee extensors under control (CON) conditions after passive heat...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,随机对照试验


    authors: Brazaitis M,Skurvydas A,Pukėnas K,Daniuseviciūtė L,Mickevicienė D,Solianik R

    更新日期:2012-11-01 00:00:00

  • Helix-loop-helix transcription factors in electrically active and inactive skeletal muscles.

    abstract::The muscle-specific helix-loop-helix (HLH) transcription factors myoD, myogenin, MRF4, and myf-5 are called the muscle regulatory factor family (MRF). Levels of MRFs are strongly regulated by muscle electrical activity and are thought to control downstream genes that are important for muscle phenotype such as the acet...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Carlsen H,Gundersen K

    更新日期:2000-09-01 00:00:00

  • Electrophysiologic investigation of thallium poisoning.

    abstract::Electrophysiologic findings in thallium intoxication are usually untimely, limited in extent, and often uninformative. This report documents serial conduction and electromyographic findings in a case of thallium poisoning, beginning 10 days after symptom onset and ending 24 months later. Initially, the plantar nerves ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Dumitru D,Kalantri A

    更新日期:1990-05-01 00:00:00

  • Limits of normal nerve function during high-frequency stimulation.

    abstract::We studied the effects of prolonged high-frequency stimulation in normal rat tail nerves. Nerves could conduct impulses at 50 Hz for 5 hours without complete conduction block. However, over time there was a significant decrease in amplitude and increase in latency of the compound nerve action potential (CNAP), which g...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Robinson LR,Nielsen VK

    更新日期:1990-04-01 00:00:00

  • Dual-energy X-ray absorptiometry in neuromuscular diseases.

    abstract::Body components were measured noninvasively in patients with neuromuscular disease by using dual-energy X-ray absorptiometry (DXA), capable of separately analyzing fat, bone, and muscle content. In all patients with muscle atrophy of myogenic or neurogenic origin, muscle mass was markedly reduced. Although all three c...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Kanda F,Fujii Y,Takahashi K,Fujita T

    更新日期:1994-04-01 00:00:00

  • Electromyography of the anal sphincter: which muscle to examine?

    abstract::Electromyographic examination of the deeper external anal sphincter (EAS) muscle is far more uncomfortable than of the subcutaneous muscle, so we tested the need for its examination. We compared the findings in 85 paired examinations of ipsilateral subcutaneous and deeper EAS muscles in 67 patients with a cauda equina...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Podnar S

    更新日期:2003-09-01 00:00:00

  • Clinicopathological study of an autopsy case with sensory-dominant polyradiculoneuropathy with antiganglioside antibodies.

    abstract::A previously reported patient presenting sensory-dominant neuropathy with antiganglioside antibodies, bound preferentially to polysialogangliosides including GD1b, was autopsied. While axonal degeneration was predominant in the sural nerve, many demyelinated fibers were present in the spinal roots. Dorsal roots had un...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Obi T,Murakami T,Takatsu M,Kusunoki S,Serizawa M,Mizoguchi K,Koike R,Nishimura Y

    更新日期:1999-10-01 00:00:00

  • Discrimination of spinal and bulbar muscular atrophy from amyotrophic lateral sclerosis using sensory nerve action potentials.

    abstract:INTRODUCTION:Spinal and bulbar muscular atrophy (SBMA) and amyotrophic lateral sclerosis (ALS) are motor neuron diseases. Sensory impairment is sometimes observed, and electrophysiological involvement has been described in the sensory nerves of SBMA patients. We hypothesized that a sensory nerve conduction study (NCS) ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Hama T,Hirayama M,Hara T,Nakamura T,Atsuta N,Banno H,Suzuki K,Katsuno M,Tanaka F,Sobue G

    更新日期:2012-02-01 00:00:00

  • Subacute demyelinating polyradiculoneuropathy complicating Epstein-Barr virus infection in GATA2 haploinsufficiency.

    abstract:INTRODUCTION:Autosomal dominant haploinsufficiency of GATA2 causes monocytopenia and natural killer cell lymphopenia, resulting in predisposition to mycobacterial, fungal, and viral infections. METHODS:Herein we report on the clinical, serologic, electrophysiologic, and pathologic evaluations of a 29-year-old woman wi...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Kazamel M,Klein CJ,Benarroch EE,Patnaik MM,Tracy JA

    更新日期:2018-01-01 00:00:00

  • The temperature dependence of halothane-induced contractures of skeletal muscle.

    abstract::Frog muscles bathed in solutions equilibrated with 0.5%-2.0% halothane develop large contractures when cooled to 2-4 degrees C. These halothane-cooling contractures (HCC) are dose dependent and reproducible; they are potentiated by lidocaine (5 mM), abolished by procaine (5 mM), and partially inhibited by procainamide...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Suarez-Kurtz G,Sudo RT

    更新日期:1986-01-01 00:00:00

  • Prolonged erythropoietin treatment does not impact gene expression in human skeletal muscle.

    abstract:INTRODUCTION:We tested for the presence of erythropoietin receptor (Epo-R) in human skeletal muscle and alterations in gene expression after prolonged use of an erythropoiesis-stimulating agent (ESA). METHODS:Nine healthy men were treated with ESA for 10 weeks (darbepoietin alfa). Muscle biopsies were collected before...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Christensen B,Nellemann B,Thorsen K,Nielsen MM,Pedersen SB,Ornstrup MJ,JØrgensen JO,Jessen N

    更新日期:2015-04-01 00:00:00

  • Multifocal motor neuropathy: current concepts and controversies.

    abstract::Multifocal motor neuropathy (MMN) is now a well-defined purely motor multineuropathy characterized by the presence of multifocal partial motor conduction blocks (CB), frequent association with anti-GM1 IgM antibodies, and usually a good response to high-dose intravenous immunoglobulin (IVIg) therapy. However, several ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,评审


    authors: Nobile-Orazio E,Cappellari A,Priori A

    更新日期:2005-06-01 00:00:00

  • Did giant mitochondria delay muscle maturation? An uncommon congenital myopathy.

    abstract:INTRODUCTION:Mitochondria are semi-autonomous organelles that are able to change their shape, size, location, and number inside the living cell. Mitochondrial division is an extremely important process, because cell survival depends on there being an adequate number of mitochondria in each cell. The dynamics of these o...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Fidziańska A,Glinka Z

    更新日期:2012-07-01 00:00:00

  • Two types of mitochondrial crystals in diseased human skeletal muscle fibers.

    abstract::Mitochondrial crystalline inclusions, frequently found in mitochondrial myopathies, were analyzed by crystallographic techniques and computer-aided image processing. It could be shown that these structures were real crystals. There are two distinct types of crystal, which can be distinguished by shape, size, and patte...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Farrants GW,Hovmöller S,Stadhouders AM

    更新日期:1988-01-01 00:00:00

  • Clinical utility of RNA sequencing to resolve unusual GNE myopathy with a novel promoter deletion.

    abstract:INTRODUCTION:UDP N-acetylglucosamine2-epimerase/N-acetylmannosamine-kinase (GNE) gene mutations can cause mostly autosomal-recessive myopathy with juvenile-onset known as hereditary inclusion-body myopathy (HIBM). METHODS:We describe a family of a patient showing an unusual HIBM with both vacuolar myopathy and myositi...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Chakravorty S,Berger K,Arafat D,Nallamilli BRR,Subramanian HP,Joseph S,Anderson ME,Campbell KP,Glass J,Gibson G,Hegde M

    更新日期:2019-07-01 00:00:00

  • Electromyographic and morphological functional compensation in late poliomyelitis.

    abstract::Patients with prior poliomyelitis may experience muscle function deterioration decades after onset of disease. The present study is aimed at describing electromyographic and morphometric evidence of muscular compensation and of on-going muscular instability. Ten subjects 42-62 years of age with onset of polio 25-52 ye...

    journal_title:Muscle & nerve

    pub_type: 临床试验,杂志文章


    authors: Einarsson G,Grimby G,Stålberg E

    更新日期:1990-02-01 00:00:00

  • CMAP variability as a function of electrode site and size.

    abstract::The site of the recording electrode influences the amplitude of the compound muscle action potential (CMAP) and its variation over a length of nerve. The effects of large electrodes on this source of intraindividual variability were assessed. Right median nerves of 20 healthy subjects were studied, and recordings made...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: van Dijk JG,Tjon-a-Tsien A,van der Kamp W

    更新日期:1995-01-01 00:00:00

  • Multifocal motor neuropathy: electrodiagnostic features.

    abstract::Diagnosis of multifocal motor neuropathy (MMN), a syndrome characterized by progressive asymmetric weakness with intact sensation, is important because the disorder often responds to treatment. Multifocal partial motor conduction block (PMCB) has been emphasized as a cardinal feature in the diagnosis of this syndrome,...

    journal_title:Muscle & nerve

    pub_type: 杂志文章


    authors: Chaudhry V,Corse AM,Cornblath DR,Kuncl RW,Freimer ML,Griffin JW

    更新日期:1994-02-01 00:00:00

  • Invited review: peripheral neuropathy in Sjogren's syndrome.

    abstract::Our experience and review of the literature reveal that Sjogren's syndrome (SS) is an important, poorly recognized cause of peripheral neuropathy. Several forms of peripheral nerve dysfunction occur in SS including trigeminal sensory neuropathy, mononeuropathy multiplex, distal sensory neuropathy, distal sensorimotor ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,评审


    authors: Kaplan JG,Rosenberg R,Reinitz E,Buchbinder S,Schaumburg HH

    更新日期:1990-07-01 00:00:00