Emetine myopathy: two case reports with pathobiochemical analysis.

abstract：:The muscle-specific helix-loop-helix (HLH) transcription factors myoD, myogenin, MRF4, and myf-5 are called the muscle regulatory factor family (MRF). Levels of MRFs are strongly regulated by muscle electrical activity and are thought to control downstream genes that are important for muscle phenotype such as the acet...

journal_title：Muscle & nerve

authors： Carlsen H,Gundersen K

更新日期：2000-09-01 00:00:00

abstract：:The presence of differences in motor unit activity across contraction types and between hands suggests that the magnitude of fluctuations in motor output is only weakly related when these conditions are compared. Twenty right-handed young (24.1 +/- 5.3 years) and old (72.5 +/- 4.9 years) adults performed three levels ...

journal_title：Muscle & nerve

authors： Shinohara M,Keenan KG,Enoka RM

更新日期：2005-06-01 00:00:00

abstract：:Little attention has been paid to small-fiber dysfunction in carpal tunnel syndrome (CTS) although its symptoms are common. This study investigates vasomotor dysfunction, which is controlled by small nerve fibers, in patients with CTS compared with control subjects. Vasomotor function was quantified by measuring, with...

journal_title：Muscle & nerve

authors： Wilder-Smith EP,Fook-Chong S,Chew SE,Chow A,Guo Y

更新日期：2003-11-01 00:00:00

abstract：:Mutations in CLCN1, the gene encoding the ClC-1 chloride channel in skeletal muscle, lead to myotonia congenita. The effects on the intramembranous channel forming domains have been investigated more than that at the intracellular C-terminus. We have performed a mutation screen involving the whole CLCN1 gene of patien...

journal_title：Muscle & nerve

authors： Chen L,Schaerer M,Lu ZH,Lang D,Joncourt F,Weis J,Fritschi J,Kappeler L,Gallati S,Sigel E,Burgunder JM

更新日期：2004-05-01 00:00:00

abstract：:We measured acetylcholinesterase (AChE) in the non-endplate region of rat muscle, documenting its intrinsic activity within muscle fibers, as well as the extrinsic level in the capillaries and endomysium. When each muscle was considered as a whole, intrinsic AChE activity detected within the fibers was stronger in the...

journal_title：Muscle & nerve

authors： Nakano S,Akiguchi I,Yasuda Y,Nakamura S,Kameyama M,Kimura J

更新日期：1990-08-01 00:00:00

abstract：INTRODUCTION:The aim of this study was to determine factors affecting health-related quality of life (HRQOL) and to propose appropriate treatment targets for patients with myasthenia gravis (MG). METHODS:We evaluated 640 consecutive patients with MG seen at 11 neurological centers. Two-year follow-up data were obtaine...

journal_title：Muscle & nerve

authors： Utsugisawa K,Suzuki S,Nagane Y,Masuda M,Murai H,Imai T,Tsuda E,Konno S,Nakane S,Suzuki Y,Fujihara K,Suzuki N

更新日期：2014-10-01 00:00:00

abstract：:A treatment has been developed to alleviate muscle weakness in murine dystrophy. Cultured myoblasts from genetically normal mouse embryos were injected into the right soleus of 20-day-old normal or dystrophic mice. Hosts and donors were immunocompatible but exhibited different genotype markers. Donor cells produced GP...

journal_title：Muscle & nerve

authors： Law PK,Goodwin TG,Wang MG

更新日期：1988-06-01 00:00:00

abstract：:Type 1 diabetes mellitus (T1DM) is associated with a peripheral neuropathy that reduces nerve conduction velocity. This may impair high motor-unit discharge frequencies (MUDF), decrease muscle activation, and curtail the ability to sustain repetitive contractile tasks. We examined (1) whether MUDF, the contractile pro...

journal_title：Muscle & nerve

authors： Almeida S,Riddell MC,Cafarelli E

更新日期：2008-02-01 00:00:00

abstract：:We applied the singular value decomposition (SVD) method to study single motor unit firing patterns. Two projects were carried out: (1) a computer simulation study to confirm the meanings of two SVD parameters, the eigenvalue corresponding to the positive-slope eigenvector (PEV) and that corresponding to the negative-...

journal_title：Muscle & nerve

authors： Sun TY,Chen JJ,Lin TS

更新日期：2000-07-01 00:00:00

abstract：INTRODUCTION:Far-field potentials (FFPs) from muscles other than the abductor digiti minimi (ADM) may interfere with motor unit number estimation (MUNE) from that muscle. METHODS:We identified the origin of each surface motor unit potential (SMUP) during hypothenar MUNE using the multiple point stimulation method in 2...

journal_title：Muscle & nerve

authors： Kawamura Y,Sonoo M,Higashihara M,Chiba T,Hatanaka Y

更新日期：2013-08-01 00:00:00

abstract：:Bcl-2 and Bax immunohistochemistry was examined in the skeletal muscle of rats after cutting the sciatic nerve, as a model of denervation and reinnervation, and in the anterior tibialis muscle of rats after an intramuscular injection of metoclopramide, as a model of necrosis and regeneration of muscle fibers, to bette...

journal_title：Muscle & nerve

authors： Olivé M,Ferrer I

更新日期：2000-12-01 00:00:00

abstract：:The distribution of collagen types I, III, and V and fibronectin was investigated by means of immunofluorescent techniques in denervated and normal rat skeletal muscle. During a period of 28 days, a distinct atrophy developed in the denervated gastrocnemius muscle and was accompanied by an increase in types I and III ...

journal_title：Muscle & nerve

authors： Salonen V,Lehto M,Kalimo M,Penttinen R,Aro H

更新日期：1985-02-01 00:00:00

abstract：INTRODUCTION:Cranial muscle fasciculations may be difficult to detect in amyotrophic lateral sclerosis (ALS). Ultrasound (US) detection of fasciculations in these muscles may have clinical utility. METHODS:Patients with suspected ALS were prospectively enrolled. Nerve conduction studies, needle electromyography (EMG),...

journal_title：Muscle & nerve

authors： O'gorman CM,Weikamp JG,Baria M,Van Den Engel-Hoek L,Kassardjian C,Van Alfen N,Boon AJ

更新日期：2017-12-01 00:00:00

abstract：INTRODUCTION:The contribution of cranial and thoracic region electromyography (EMG) to diagnostic criteria for amyotrophic lateral sclerosis (ALS) has not been evaluated. METHODS:Clinical and EMG data from each craniospinal region were retrospectively assessed in 470 patients; 214 had ALS. Changes to diagnostic classi...

journal_title：Muscle & nerve

authors： Jenkins TM,Alix JJ,Kandler RH,Shaw PJ,McDermott CJ

更新日期：2016-09-01 00:00:00

abstract：:This investigation analyzes the temporal characteristics of maximal depolarization times for three waveforms: end-plate spikes, fibrillation potentials, and positive sharp waves (PSWs) to provide support for the electrode initiation hypothesis of PSW induction. The maximal depolarization times for PSWs are documented ...

journal_title：Muscle & nerve

authors： Dumitru D,Santa Maria DL

更新日期：2007-09-01 00:00:00

abstract：:Muscle fatigue or neuromuscular disease may result in central activation failure during maximal voluntary contractions (MVCs). Superimposition of an electrically stimulated contraction during an MVC has been used to detect central activation failure. To determine the most sensitive means of quantitating central activa...

journal_title：Muscle & nerve

authors： Kent-Braun JA,Le Blanc R

更新日期：1996-07-01 00:00:00

abstract：:Voluntary and stimulation single-fiber electromyography were performed in the extensor digitorum communis muscle of 15 myasthenic patients. The increase in mean and individual mean consecutive difference as well as the proportion of blocking in the volitional activation were greater than in the stimulation method. The...

journal_title：Muscle & nerve

authors： Murga L,Sánchez F,Menéndez C,Castilla JM

更新日期：1998-08-01 00:00:00

abstract：INTRODUCTION:Amyotrophic lateral sclerosis (ALS) is a debilitating neurologic disorder with poor survival rates and no clear biomarkers for disease diagnosis and prognosis. METHODS:We compared serum microRNA (miRNA) expression from patients with ALS with healthy controls and patients with multiple sclerosis and Alzhei...

journal_title：Muscle & nerve

authors： Raheja R,Regev K,Healy BC,Mazzola MA,Beynon V,Von Glehn F,Paul A,Diaz-Cruz C,Gholipour T,Glanz BI,Kivisakk P,Chitnis T,Weiner HL,Berry JD,Gandhi R

更新日期：2018-08-01 00:00:00

abstract：:The motor end-plate fine structure and distribution of junctional acetylcholine receptors (AChRs) in patients with amyotrophic lateral sclerosis (ALS) were studied. Morphometric analysis was carried out in 74 end-plates (92 innervated and 47 denuded postsynaptic regions) from 10 patients with ALS. AChR was studied by ...

journal_title：Muscle & nerve

authors： Tsujihata M,Hazama R,Yoshimura T,Satoh A,Mori M,Nagataki S

更新日期：1984-03-01 00:00:00

abstract：:Lamins are the principal components of the nuclear lamina, a network constituting the major structural framework of the nuclear envelope. Alterations in lamin A/C have been associated with a heterogeneous series of human disorders known as laminopathies. We report the finding of a novel deletion in the central rod dom...

journal_title：Muscle & nerve

authors： Maioli MA,Marrosu G,Mateddu A,Solla E,Carboni N,Tacconi P,Lai C,Marrosu MG

更新日期：2007-12-01 00:00:00

abstract：:Patients with chronic inflammatory demyelinating polyneuropathy (CIDP) received immune globulin intravenous, 10% caprylate/chromatography purified (IGIV-C, Gamunex; n=59) or placebo (n=58) every 3 weeks for up to 24 weeks (first period) in a randomized, double-blind, parallel-group, response-conditional, crossover stu...

journal_title：Muscle & nerve

authors： Bril V,Katzberg H,Donofrio P,Banach M,Dalakas MC,Deng C,Hanna K,Hartung HP,Hughes RA,Latov N,Merkies IS,van Doorn PA,ICE Study Group.

更新日期：2009-04-01 00:00:00

abstract：:Mitochondrial crystalline inclusions, frequently found in mitochondrial myopathies, were analyzed by crystallographic techniques and computer-aided image processing. It could be shown that these structures were real crystals. There are two distinct types of crystal, which can be distinguished by shape, size, and patte...

journal_title：Muscle & nerve

authors： Farrants GW,Hovmöller S,Stadhouders AM

更新日期：1988-01-01 00:00:00

abstract：:In this pilot study we use T2-weighted magnetic resonance imaging (MRI) to identify possible peripheral nerve inflammation in 4 patients with diffuse chronic pain. In all 4 patients, there was an increase in median and ulnar nerve T2 signal intensity at the wrist (P < 0.05 vs. controls). Positive clinical signs of per...

journal_title：Muscle & nerve

authors： Dilley A,Greening J,Walker-Bone K,Good C

更新日期：2011-12-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a debilitating neurodegenerative disorder with complex biology and significant clinical heterogeneity. Many preclinical and early phase ALS clinical trials have yielded promising results that could not be replicated in larger phase 3 confirmatory trials. One reason for the lack o...

journal_title：Muscle & nerve

authors： Goyal NA,Berry JD,Windebank A,Staff NP,Maragakis NJ,van den Berg LH,Genge A,Miller R,Baloh RH,Kern R,Gothelf Y,Lebovits C,Cudkowicz M

更新日期：2020-08-01 00:00:00

abstract：INTRODUCTION:Congenital myotonic dystrophy (CDM) occurs when symptoms of myotonic dystrophy present at birth. In this study we evaluated the relationship between physical function, muscle mass, and age to provide an assessment of the disease and help prepare for therapeutic trials. METHODS:CDM participants performed t...

journal_title：Muscle & nerve

authors： Pucillo EM,Dibella DL,Hung M,Bounsanga J,Crockett B,Dixon M,Butterfield RJ,Campbell C,Johnson NE

更新日期：2017-08-01 00:00:00

abstract：INTRODUCTION:This study sought to estimate the global prevalence of transthyretin familial amyloid polyneuropathy (ATTR-FAP). METHODS:Prevalence estimates and information supporting prevalence calculations was extracted from records yielded by reference-database searches (2005-2016), conference proceedings, and nonpee...

journal_title：Muscle & nerve

authors： Schmidt HH,Waddington-Cruz M,Botteman MF,Carter JA,Chopra AS,Hopps M,Stewart M,Fallet S,Amass L

更新日期：2018-05-01 00:00:00

abstract：:This article describes a 37-year-old woman with progressive external ophthalmoplegia, peripheral neuropathy, and chronic intractable diarrhea. Laboratory studies disclosed lactic acidosis, ragged red fibers lacking cytochrome c oxidase, high-normal muscular mitochondrial enzymes, demyelinating neuropathy, leukoencepha...

journal_title：Muscle & nerve

authors： Uncini A,Servidei S,Silvestri G,Manfredi G,Sabatelli M,Di Muzio A,Ricci E,Mirabella M,Di Mauro S,Tonali P

更新日期：1994-06-01 00:00:00

abstract：:C-protein isoform expression in hereditary dystrophic chicken skeletal muscle was compared with that in normal chicken muscle during postnatal development by immunocytochemical and immunoblot methods. In the pectoralis muscle (PM) of both normal and dystrophic chicken, slow- and fast-type C-proteins were coexpressed i...

journal_title：Muscle & nerve

authors： Obinata T,Shinbo K

更新日期：1987-05-01 00:00:00

abstract：:Limb-girdle muscular dystrophy type 2A (LGMD2A) is an autosomal-recessive disorder characterized by selective atrophy and progressive weakness of proximal girdle muscles. LGMD2A, the most prevalent form of LGMD, is caused by mutations in the CAPN3 gene that encodes the skeletal muscle-specific member of the calpain fa...

journal_title：Muscle & nerve

authors： Hermanová M,Zapletalová E,Sedlácková J,Chrobáková T,Letocha O,Kroupová I,Zámecník J,Vondrácek P,Mazanec R,Maríková T,Vohánka S,Fajkusová L

更新日期：2006-03-01 00:00:00

abstract：:Single fiber electromyography ( SFEMG ) of the extensor digitorum communis (EDC) muscle and nerve conduction studies were performed on healthy, active elderly men (66-77 years old) to assess age-related changes in neuromuscular physiology and the effect of long-term increased muscular activity on these changes. The fo...

journal_title：Muscle & nerve

authors： Shields RW Jr,Robbins N,Verrilli AA 3rd

更新日期：1984-05-01 00:00:00