Positive sharp wave origin: evidence supporting the electrode initiation hypothesis.

Abstract:

:This investigation analyzes the temporal characteristics of maximal depolarization times for three waveforms: end-plate spikes, fibrillation potentials, and positive sharp waves (PSWs) to provide support for the electrode initiation hypothesis of PSW induction. The maximal depolarization times for PSWs are documented to comprise two distinct populations conforming to relatively short and comparatively longer maximal depolarization times. Those PSWs with short maximal depolarization times were found to be equivalent to end-plate spike maximal depolarization times, whereas those with longer times were comparable to fibrillation potentials. The PSW group with shorter maximal depolarization times was encountered more frequently. The combination of two distinct groups of PSWs with respective times comparable to end-plate spikes and fibrillation potentials supports the hypothesis that the majority of PSWs originate at the recording electrode during insertion, whereas a smaller population of PSWs arises as propagating fibrillation potentials that block at the recording electrode. Subcutaneous compared to intramuscular recordings from denervated muscle document that the recording electrode is necessary to both record and produce PSWs. Hence, this study confirms the proposed hypothesis that the majority of observed PSWs represent a suprathreshold single muscle-fiber discharge induced by, and originating in close proximity to, a perielectrode crushed membrane that then propagate away from the electrode; a smaller population of PSWs conform to that of a blocked fibrillation potential.

journal_name

Muscle Nerve

journal_title

Muscle & nerve

authors

Dumitru D,Santa Maria DL

doi

10.1002/mus.20819

subject

Has Abstract

pub_date

2007-09-01 00:00:00

pages

349-56

issue

3

eissn

0148-639X

issn

1097-4598

journal_volume

36

pub_type

杂志文章
  • Distal sensory nerve conduction of the superficial peroneal nerve: new method and its clinical application.

    abstract::The superficial peroneal nerve subserves sensation on the entire surface of the dorsum of the foot, except in small areas. All previously reported techniques for evaluating nerve conduction along this nerve tested a proximal portion of the nerve. We report a new method for evaluating sensory nerve conduction of the fo...

    journal_title:Muscle & nerve

    pub_type: 临床试验,杂志文章

    doi:10.1002/mus.1056

    authors: Oh SJ,Demirci M,Dajani B,Melo AC,Claussen GC

    更新日期:2001-05-01 00:00:00

  • Single motor unit H-reflex in motor neuron disorders.

    abstract::The latency fluctuation of single motor unit potentials (MUPH) in the H-reflex is greater than the latency fluctuation of MUPs in the direct (MUPM) and recurrent (MUPF) responses. This has been attributed to the variability in the impulse generation at the site of nerve stimulation, and to the variation in the synapti...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880150604

    authors: Soliven B,Maselli RA

    更新日期:1992-06-01 00:00:00

  • Properties of extensor digitorum longus muscle and skinned fibers from adult and aged male and female Actn3 knockout mice.

    abstract::Absence of α-actinin-3, encoded by the ACTN3 "speed gene," is associated with poorer sprinting performance in athletes and a slowing of relaxation in fast-twitch muscles of Actn3 knockout (KO) mice. Our first aim was to investigate, at the individual-fiber level, possible mechanisms for this slowed relaxation. Our sec...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.21778

    authors: Chan S,Seto JT,Houweling PJ,Yang N,North KN,Head SI

    更新日期:2011-01-01 00:00:00

  • In vivo bioluminescent imaging of Schwann cells in a poly(DL-lactide-epsilon-caprolactone) nerve guide.

    abstract::Nerve guides seeded with Schwann cells (SCs) promote axonal regeneration in peripheral nerve lesions. We examined the applicability of bioluminescent imaging (BLI) for monitoring the fate of SCs in nerve guides after implantation. Rat SCs were transfected with the firefly luciferase (Fluc) gene and subsequently seeded...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.21372

    authors: Ma MS,Van Dam G,Meek M,Boddeke E,Copray S

    更新日期:2009-11-01 00:00:00

  • Probabilistic muscle characterization using QEMG: application to neuropathic muscle.

    abstract::Clinicians who use electromyographic (EMG) signals to help determine the presence or absence of abnormality in a muscle often, with varying degrees of success, evaluate sets of motor unit potentials (MUPs) qualitatively and/or quantitatively to characterize the muscle in a clinically meaningful way. The resulting musc...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.21456

    authors: Pino LJ,Stashuk DW,Boe SG,Doherty TJ

    更新日期:2010-01-01 00:00:00

  • Utility of whole exome sequencing in evaluation of juvenile motor neuron disease.

    abstract:INTRODUCTION:This case report focuses on identifying novel mutations in juvenile motor neuron disease and emphasizes the significance of whole exome sequencing (WES). METHODS:We report a 13-year-old Hispanic boy with rapidly progressive weakness, muscle atrophy, tremor, and tongue fasciculation, along with upper motor...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.25030

    authors: Agarwal S,Potocki L,Collier TR,Woodbury SL,Adesina AM,Jones J,Lotze TE

    更新日期:2016-04-01 00:00:00

  • Quantitative evaluation of hand motor function using a gyrosensor in mild and moderate carpal tunnel syndrome.

    abstract:INTRODUCTION:The objective of this study was to determine whether patients with carpal tunnel syndrome (CTS) manifest changes in early-stage motor function and to investigate the utility of a gyrosensor for quantitative evaluation of motor function. METHODS:Angular velocity signal was measured during finger tapping in...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.26424

    authors: Seok HY,Kim JW,Kim YH,Park MH,Kwon DY

    更新日期:2019-04-01 00:00:00

  • Thymectomy may not be associated with clinical improvement in MuSK myasthenia gravis.

    abstract:INTRODUCTION:A randomized trial demonstrated benefit from thymectomy in nonthymomatous acetylcholine receptor (AChR)-antibody positive myasthenia gravis (MG). Uncontrolled observational and histologic studies suggest thymectomy may not be efficacious in anti-muscle-specific kinase (MuSK)-MG. METHODS:The therapeutic im...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,多中心研究

    doi:10.1002/mus.26404

    authors: Clifford KM,Hobson-Webb LD,Benatar M,Burns TM,Barnett C,Silvestri NJ,Howard JF Jr,Visser A,Crum BA,Nowak R,Beekman R,Kumar A,Ruzhansky K,Chen IA,Pulley MT,Laboy SM,Fellman MA,Howard DB,Kolb NA,Greene SM,Pasnoor M

    更新日期:2019-04-01 00:00:00

  • A new mutation in the regulatory domain of the myophosphorylase gene affecting protein dimer contact.

    abstract::We have identified a novel missense mutation in the myophosphorylase gene in a Spanish patient with McArdle's disease. The patient was homozygous for a T-to-C transition at codon 115 (L115P) in exon 3, which changed an encoded leucine (CUG) to a proline (CCG). This is the first mutation to be described in exon 3 and i...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-4598(199908)22:8<1136::aid-mus2

    authors: Gamez J,Fernandez R,Bruno C,Andreu AL,Cervera C,Navarro C,Schwartz S,Dimauro S

    更新日期:1999-08-01 00:00:00

  • Changes in Na(+) channel expression and nodal persistent Na(+) currents associated with peripheral nerve regeneration in mice.

    abstract::Patients with peripheral neuropathy frequently suffer from positive sensory (pain and paresthesias) and motor (muscle cramping) symptoms even in the recovery phase of the disease. To investigate the pathophysiology of increased axonal excitability in peripheral nerve regeneration, we assessed the temporal and spatial ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.21031

    authors: Nakata M,Baba H,Kanai K,Hoshi T,Sawai S,Hattori T,Kuwabara S

    更新日期:2008-06-01 00:00:00

  • Focal inflammatory myopathy.

    abstract::We report three patients with inflammatory myopathy who presented clinically with weakness and wasting of only one limb. The myopathy progressed over 6 months and 5 years, respectively, in two patients and was stable after 8 years in the third patient. One patient had a skin rash. Serum CK was elevated in the two pati...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880070210

    authors: Lederman RJ,Salanga VD,Wilbourn AJ,Hanson MR,Dudley AW Jr

    更新日期:1984-02-01 00:00:00

  • Clinical utility of RNA sequencing to resolve unusual GNE myopathy with a novel promoter deletion.

    abstract:INTRODUCTION:UDP N-acetylglucosamine2-epimerase/N-acetylmannosamine-kinase (GNE) gene mutations can cause mostly autosomal-recessive myopathy with juvenile-onset known as hereditary inclusion-body myopathy (HIBM). METHODS:We describe a family of a patient showing an unusual HIBM with both vacuolar myopathy and myositi...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.26486

    authors: Chakravorty S,Berger K,Arafat D,Nallamilli BRR,Subramanian HP,Joseph S,Anderson ME,Campbell KP,Glass J,Gibson G,Hegde M

    更新日期:2019-07-01 00:00:00

  • Quantitative analysis of reflex inhibition in single motor units in human masseter muscle: effects of stimulus intensity.

    abstract::Inhibitory reflex responses to electrical stimulation of the mental nerve were studied in recordings from single motor units (SMU) in the human masseter muscle. A new analytical technique for spike train data was used. Electrical stimuli were delivered to the mental nerve when the SMU fired with two consecutive inter-...

    journal_title:Muscle & nerve

    pub_type: 临床试验,杂志文章

    doi:10.1002/(sici)1097-4598(200002)23:2<259::aid-mus18

    authors: Graven-Nielsen T,Svensson P,McMillan AS,Arendt-Nielsen L

    更新日期:2000-02-01 00:00:00

  • Monofocal motor neuropathy: Improvement with intravenous immunoglobulin.

    abstract::Multifocal motor neuropathy (MMN) is a chronic, immune-mediate, peripheral myelinopathy. Inherent in its name, MMN implies involvement of two or more motor nerves. We report three patients with weakness and partial motor conduction block restricted to a single nerve and localized to sites that are not at risk for entr...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.10088

    authors: Felice KJ,Goldstein JM

    更新日期:2002-05-01 00:00:00

  • Pseudometabolic presentation of dystrophinopathy due to a missense mutation.

    abstract::Exercise intolerance with myalgia, muscle stiffness, and recurrent rhabdomyolysis due to mutations in the DMD gene can mimic metabolic myopathies leading to delayed or inaccurate diagnoses. In this retrospective chart review, we report 3 unrelated boys with exertional myalgia, muscle stiffness, myoglobinuria, and norm...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.21823

    authors: Veerapandiyan A,Shashi V,Jiang YH,Gallentine WB,Schoch K,Smith EC

    更新日期:2010-12-01 00:00:00

  • Cytoplasmic body myopathy masquerading as motor neuron disease.

    abstract::Cytoplasmic body myopathy (CBM) is characterized by proteinaceous inclusion bodies in muscle tissue. A 43-year-old woman presented with rapidly progressive weakness and dysphagia. Electromyography (EMG) elsewhere demonstrated lower-limb chronic partial denervation. Muscle biopsy showed fiber size variation without dia...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.20115

    authors: Krishnan AV,Pamphlett R,Burke D,Wills EJ,Kiernan MC

    更新日期:2004-11-01 00:00:00

  • Function of thick and thin nerve fibers in carpal tunnel syndrome before and after surgical treatment.

    abstract::Present studies evaluated the functions of thick and thin nerve fibers in carpal tunnel syndrome (CTS) to determine whether data of thin nerve fibers can add further information to the diagnosis of CTS. Measurements were performed in 22 patients and 16 age-matched control subjects. Motor and sensory nerve conduction, ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880180210

    authors: Lang E,Spitzer A,Pfannmüller D,Claus D,Handwerker HO,Neundörfer B

    更新日期:1995-02-01 00:00:00

  • Abductor hallucis false motor points: electrophysiologic mapping and cadaveric dissection.

    abstract::False motor points (FMPs) can occur in intrinsic foot or hand muscles, causing spuriously prolonged distal motor latencies by misrepresenting the compound muscle action potential (CMAP) onset. We investigated the motor point (MP) and possible FMPs in abductor hallucis (AH) by three methods: (1) electrophysiologic mapp...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-4598(199609)19:9<1138::AID-MUS9

    authors: Del Toro DR,Park TA

    更新日期:1996-09-01 00:00:00

  • COVID-19-associated Guillain-Barré syndrome: The early pandemic experience.

    abstract::Guillain-Barré syndrome (GBS) is an inflammatory polyradiculoneuropathy associated with numerous viral infections. Recently, there have been many case reports describing the association between coronavirus disease-2019 (COVID-19) and GBS, but much remains unknown about the strength of the association and the features ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,评审

    doi:10.1002/mus.27024

    authors: Caress JB,Castoro RJ,Simmons Z,Scelsa SN,Lewis RA,Ahlawat A,Narayanaswami P

    更新日期:2020-10-01 00:00:00

  • Axonal excitability during ischemia in MELAS.

    abstract:INTRODUCTION:In mitochondrial disease, it is likely that energy substrate depletion leads to paralysis of ATPase-dependent pumps, resulting in membrane depolarization. Axonal depolarization has been demonstrated in a crisis, but not in the resting state. We, therefore, stressed axons using ischemia to see if this would...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.23733

    authors: Ng K,Kumar KR,Sue C,Burke D

    更新日期:2013-05-01 00:00:00

  • Evaluation of admittance control as an alternative to passive arm supports to increase upper extremity function for individuals with Duchenne muscular dystrophy.

    abstract::The degree of upper extremity active range of motion provided by an admittance control robot compared with a commercially available passive arm support for individuals with DMD who have limited arm function was investigated in this study. The reachable workspace evaluation was used to assess active range of motion pro...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,评审

    doi:10.1002/mus.26848

    authors: Corrigan MC,Foulds RA

    更新日期:2020-06-01 00:00:00

  • Frequency and spectrum of myopathies in patients with psoriasis.

    abstract:INTRODUCTION:Psoriasis is a T-cell-mediated skin disorder with uncommon extracutaneous manifestations. Rare patients with psoriasis and myopathy have been reported. METHODS:We conducted a retrospective review of medical records of psoriasis patients seen at the Mayo Clinic during the period from January 1, 1996 to May...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.23812

    authors: Liewluck T,Ernste FC,Tracy JA

    更新日期:2013-11-01 00:00:00

  • Inflammatory demyelinating neuropathy heralding accelerated chediak-higashi syndrome.

    abstract:INTRODUCTION:Chediak-Higashi syndrome (CHS) is a very rare autosomal recessive disorder (gene CHS1/LYST) characterized by partial albinism, recurrent infections, and easy bruising. Survivors develop a constellation of slowly progressive neurological manifestations. METHODS:We describe clinical, laboratory, electrophys...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.25414

    authors: Faber IV,Prota JRM,Martinez ARM,Nucci A,Lopes-Cendes I,Júnior MCF

    更新日期:2017-05-01 00:00:00

  • Immunohistochemical characterization of human masseter muscle spindles.

    abstract::An enzyme- and immunohistochemical study has been performed on human masseter muscle spindles. Antibodies selective for different myosin heavy chain (MHC) isoforms and M-band proteins (M-protein, myomesin, and MM-CK) were used. The expression of these proteins was determined in the different intrafusal fiber types. Nu...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880170105

    authors: Eriksson PO,Butler-Browne GS,Thornell LE

    更新日期:1994-01-01 00:00:00

  • Biochemical functioning of mitochondria in normal and denervated mammalian skeletal muscle.

    abstract::Mitochondrial preparations derived from denervated rat skeletal muscle and paired control muscle are characterized with respect to their oxidative and phosphorylative capacities. Our data indicate that there is an impairment within the first 2 energy coupling regions of the respiratory chain and within the ATPase comp...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880040608

    authors: Joffe M,Savage N,Isaacs H

    更新日期:1981-11-01 00:00:00

  • Exon 17 skipping in CLCN1 leads to recessive myotonia congenita.

    abstract::Mutations in CLCN1, the gene encoding the ClC-1 chloride channel in skeletal muscle, lead to myotonia congenita. The effects on the intramembranous channel forming domains have been investigated more than that at the intracellular C-terminus. We have performed a mutation screen involving the whole CLCN1 gene of patien...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.20005

    authors: Chen L,Schaerer M,Lu ZH,Lang D,Joncourt F,Weis J,Fritschi J,Kappeler L,Gallati S,Sigel E,Burgunder JM

    更新日期:2004-05-01 00:00:00

  • A standardized clinical evaluation of patients affected by facioscapulohumeral muscular dystrophy: The FSHD clinical score.

    abstract::To define numerically the clinical severity of facioscapulohumeral muscular dystrophy (FSHD), we developed a protocol that quantifies muscle weakness by combining the functional evaluation of six muscle groups affected in this disease. To validate reproducibility of the protocol, 69 patients were recruited. Each patie...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.21671

    authors: Lamperti C,Fabbri G,Vercelli L,D'Amico R,Frusciante R,Bonifazi E,Fiorillo C,Borsato C,Cao M,Servida M,Greco F,Di Leo R,Volpi L,Manzoli C,Cudia P,Pastorello E,Ricciardi L,Siciliano G,Galluzzi G,Rodolico C,Santoro L

    更新日期:2010-08-01 00:00:00

  • Diagnostic value of nerve biopsy for atypical chronic inflammatory demyelinating polyneuropathy: evaluation of eight cases.

    abstract::The diagnosis of chronic inflammatory demyelinating polyneuropathy (CIDP) relies primarily on clinical and electrophysiologic examination, but the nerve biopsy findings may be supportive, especially in atypical cases. In order to define the usefulness of nerve biopsy in this disease, we retrospectively studied 44 cons...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.10348

    authors: Vallat JM,Tabaraud F,Magy L,Torny F,Bernet-Bernady P,Macian F,Couratier P

    更新日期:2003-04-01 00:00:00

  • Assessing the modulation of cutaneous sensory fiber excitability using a fast perception threshold tracking technique.

    abstract:INTRODUCTION:Topical application of lidocaine-and-prilocaine (LP) cream attenuates the functionality of small cutaneous nerve fibers. The aim of this human study was to measure the underlying excitability modulation of small cutaneous nerve fibers using a novel and fast perception threshold tracking (PTT) technique. M...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/mus.26520

    authors: Nielson Hoberg T,Frahm S,Hennings K,Arendt-Nielsen L,Dahl Mørch C

    更新日期:2019-10-01 00:00:00

  • Function of death-associated protein 1 in proliferation, differentiation, and apoptosis of chicken satellite cells.

    abstract:INTRODUCTION:Muscle growth and regeneration are processes closely associated with proliferation, differentiation, and apoptosis of muscle cells. Death-associated protein 1 (DAP1) has been identified as a negative regulator of autophagy. Little is known about the function of DAP1 in the regulation of myogenesis and sate...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.23832

    authors: Shin J,McFarland DC,Strasburg GM,Velleman SG

    更新日期:2013-11-01 00:00:00