Abstract:
INTRODUCTION:Topical application of lidocaine-and-prilocaine (LP) cream attenuates the functionality of small cutaneous nerve fibers. The aim of this human study was to measure the underlying excitability modulation of small cutaneous nerve fibers using a novel and fast perception threshold tracking (PTT) technique. METHODS:Small sensory fibers were selectively blocked by 120-minute topical application of LP and confirmed by quantitative sensory testing. Excitability changes of small (activated by a specially designed pin electrode) and large (patch electrode) nerve fibers were assessed as the strength-duration relation and threshold electrotonus. RESULTS:The excitability assessed by the strength-duration relation and threshold electrotonus was significantly modulated for the small afferents (P < 0.05, Wilcoxon's test) but not the large afferents. DISCUSSION:This novel PTT technique was able to assess inhibition of membrane properties of small cutaneous fibers, suggesting the usefulness of the technique as a diagnostic method for assessing impairment of small fibers, as seen in many types of polyneuropathies.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Nielson Hoberg T,Frahm S,Hennings K,Arendt-Nielsen L,Dahl Mørch Cdoi
10.1002/mus.26520subject
Has Abstractpub_date
2019-10-01 00:00:00pages
367-375issue
4eissn
0148-639Xissn
1097-4598journal_volume
60pub_type
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