Abstract:
:Cytoplasmic body myopathy (CBM) is characterized by proteinaceous inclusion bodies in muscle tissue. A 43-year-old woman presented with rapidly progressive weakness and dysphagia. Electromyography (EMG) elsewhere demonstrated lower-limb chronic partial denervation. Muscle biopsy showed fiber size variation without diagnostic features. A diagnosis of possible motor neuron disease was made and the patient was commenced on riluzole. Subsequently, the patient's condition stabilized, prompting reassessment. Repeat EMG demonstrated no features of denervation and was more suggestive of a myopathic process. Review of the original muscle biopsy showed cytoplasmic bodies. The case highlights a further diagnostic possibility in the assessment of patients with "possible" motor neuron disease. The clinical features of CBM are briefly reviewed.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Krishnan AV,Pamphlett R,Burke D,Wills EJ,Kiernan MCdoi
10.1002/mus.20115subject
Has Abstractpub_date
2004-11-01 00:00:00pages
667-72issue
5eissn
0148-639Xissn
1097-4598journal_volume
30pub_type
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