Abstract:
:Cytoplasmic body myopathy (CBM) is characterized by proteinaceous inclusion bodies in muscle tissue. A 43-year-old woman presented with rapidly progressive weakness and dysphagia. Electromyography (EMG) elsewhere demonstrated lower-limb chronic partial denervation. Muscle biopsy showed fiber size variation without diagnostic features. A diagnosis of possible motor neuron disease was made and the patient was commenced on riluzole. Subsequently, the patient's condition stabilized, prompting reassessment. Repeat EMG demonstrated no features of denervation and was more suggestive of a myopathic process. Review of the original muscle biopsy showed cytoplasmic bodies. The case highlights a further diagnostic possibility in the assessment of patients with "possible" motor neuron disease. The clinical features of CBM are briefly reviewed.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Krishnan AV,Pamphlett R,Burke D,Wills EJ,Kiernan MCdoi
10.1002/mus.20115subject
Has Abstractpub_date
2004-11-01 00:00:00pages
667-72issue
5eissn
0148-639Xissn
1097-4598journal_volume
30pub_type
杂志文章相关文献
MUSCLE & NERVE文献大全abstract::This study contrasts the developmental patterns of expression of 2 subtypes of the voltage-dependent sodium channel in rat muscle that are differentiated by their immunoreactivity with monoclonal antibodies raised to the purified muscle sodium channel protein. One subtype is found in the transverse tubular (T) system ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880140209
更新日期:1991-02-01 00:00:00
abstract:INTRODUCTION:We sought to determine whether electrical impedance myography (EIM) could serve as a diagnostic procedure for evaluation of radiculopathy. METHODS:Twenty-seven patients with clinically and radiologically diagnosed cervical or lumbosacral radiculopathy who met a "gold standard" definition underwent EIM and...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.23833
更新日期:2013-11-01 00:00:00
abstract::Variable-frequency stimulation trains (VFTs) that take advantage of the catchlike property of skeletal muscle have been shown to augment the force production of fatigued muscles compared with constant-frequency trains (CFTs). The present study is the first to report the force augmentation produced by VFTs after fatigu...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(199809)21:9<1145::aid-mus5
更新日期:1998-09-01 00:00:00
abstract::Hereditary neuropathy with liability to pressure palsy (HNPP) is typified as isolated nerve palsies caused by trivial compression or trauma. It rarely presents in two extremities and even more infrequently affects all four limbs simultaneously. We present a patient who concurrently experienced right shoulder, left han...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(200006)23:6<979::aid-mus23
更新日期:2000-06-01 00:00:00
abstract::Electrodiagnostic studies were analyzed in patients with neuropathy associated with IgM monoclonal proteins, 7 with anti-myelin associated glycoprotein reactivity (MAG) and 7 nonreactive to MAG. The findings were distinctly different in the two groups. The electrodiagnostic studies of all the MAG-reactive patients had...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880131205
更新日期:1990-12-01 00:00:00
abstract::The dystrophin protein complex (DPC), composed of at least 10 proteins that associate with dystrophin, is critical for the maintenance of normal muscle fiber structure and physiology. In this study, we used immunohistochemistry and confocal microscopy to examine the relative abundance and distribution of several of th...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/1097-4598(200102)24:2<262::aid-mus120>3.0.
更新日期:2001-02-01 00:00:00
abstract:INTRODUCTION:An enlarged tongue (macroglossia) has been reported in advanced-stage patients with amyotrophic lateral sclerosis (ALS). METHODS:In this study we examined the prevalence of macroglossia and analyzed clinical correlations in 65 ALS patients on tracheostomy-invasive ventilation (TIV). RESULTS:Macroglossia ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25058
更新日期:2016-09-01 00:00:00
abstract::The purpose of this study was to determine if chronic fatigue syndrome (CSF) is characterized by abnormalities in oxidative muscle metabolism. Patients with CFS according to Centers for Disease Control (CDC) criteria (n = 22) were compared to normal sedentary subjects (n = 15). CFS patients were also tested before and...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4598(199605)19:5<621::AID-MUS10
更新日期:1996-05-01 00:00:00
abstract::A patient with neuromyotonia, peripheral neuropathy and myasthenia gravis (MG) is described. Neurophysiological studies, at rest, showed continuous muscle discharges of motor unit action potentials (MUAPs) in duplets and triplets. Motor (MNCV) and sensory (SNCV) nerve conduction studies revealed mild axonal and demyel...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4598(199604)19:4<505::AID-MUS10
更新日期:1996-04-01 00:00:00
abstract::A method for quantifying shape variability, the jiggle, or motor unit potentials (MUPs) recorded with conventional EMG electrodes is presented. Amplitude variability at each point of time of the MUP was analyzed. Two new parameters are proposed: the normalized value of the consecutive amplitude differences (CAD), and ...
journal_title:Muscle & nerve
pub_type: 临床试验,杂志文章
doi:10.1002/mus.880171003
更新日期:1994-10-01 00:00:00
abstract::The effect of endurance training on muscle electrical activity during general exercise testing was investigated in physically active patients with chronic obstructive pulmonary disease (COPD). Before and after rehabilitation, patients performed identical incremental exercise tests. Pulmonary gas exchange, venous lacta...
journal_title:Muscle & nerve
pub_type: 临床试验,杂志文章
doi:10.1002/mus.10491
更新日期:2003-12-01 00:00:00
abstract::The cerebrospinal fluid (CSF) of patients with demyelinating neurological disease, such as Guillain-Barré syndrome or multiple sclerosis, contains factors that inhibit the excitatory Na+ current. Such antiexcitatory factors are occasionally also detectable in CSF from patients with other neurological diseases but were...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4598(199601)19:1<54::AID-MUS7>3
更新日期:1996-01-01 00:00:00
abstract:INTRODUCTION:We describe the ultrasonographic findings of sciatic nerve endometriosis. METHODS:Two premenopausal women with catamenial sciatica symptoms were examined, the first without a history of endometriosis, the second with previously confirmed endometriosis of the ovary. Ultrasonography, extending from the scia...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25152
更新日期:2016-09-01 00:00:00
abstract:INTRODUCTION:Cachexia increases morbidity and mortality of cancer patients. The progressive loss of muscle mass negatively affects physical function and quality of life. We previously showed reduced muscle insulin-like growth factor-1 (IGF-1) expression and enhanced myostatin signaling in tumor-bearing animals. This st...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.23798
更新日期:2013-09-01 00:00:00
abstract:INTRODUCTION:The objective of this study was to identify the pattern of neurological deficits and document electrophysiological changes in women with macromastia. METHODS:Patients with macromastia and neurological complaints underwent clinical evaluation and electrodiagnostic (EDx) studies of the upper limbs. RESULTS...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.23501
更新日期:2013-02-01 00:00:00
abstract:INTRODUCTION:This study compares the acute and chronic response of high-load resistance training (HL) to low-load resistance training with low blood flow restriction (LL-BFR) pressure. METHODS:Participants completed elbow flexion with either HL or LL-BFR or nonexercise. In the chronic study, participants in the HL and...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25626
更新日期:2017-12-01 00:00:00
abstract::We used peristimulus time histograms (PSTHs) to estimate characteristics of the composite excitatory postsynaptic potentials (EPSPs) generated at the anterior horn cell by a descending cortical volley induced by subthreshold transcranial magnetic stimuli in 11 normal subjects, 9 patients with DNA-confirmed Kennedy's d...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(199903)22:3<299::aid-mus2>
更新日期:1999-03-01 00:00:00
abstract:INTRODUCTION:Topical application of lidocaine-and-prilocaine (LP) cream attenuates the functionality of small cutaneous nerve fibers. The aim of this human study was to measure the underlying excitability modulation of small cutaneous nerve fibers using a novel and fast perception threshold tracking (PTT) technique. M...
journal_title:Muscle & nerve
pub_type: 杂志文章,随机对照试验
doi:10.1002/mus.26520
更新日期:2019-10-01 00:00:00
abstract:INTRODUCTION:We investigated the effects of aerobic and resistance exercise in patients with chronic inflammatory demyelinating polyneuropathy (CIDP). METHODS:Eighteen CIDP patients treated with subcutaneous immunoglobulin performed 12 weeks of aerobic exercise and 12 weeks of resistance exercise after a run-in period...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25652
更新日期:2018-01-01 00:00:00
abstract::A low conductance calcium-activated K+ channel is thought to regulate the rate of firing of several excitable cells. In skeletal muscle the expression of this channel is under nerve control. Previously, we reported that axonal flow blockade of rat nerves, induced by colchicine, caused a transient increase in muscle ap...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880160908
更新日期:1993-09-01 00:00:00
abstract::The aim of this investigation was to define the boundaries of compound motor action potential (CMAP) dispersion, amplitude decay, and area decay in a control population and determine their dependence on external variables such as age and interelectrode distance. Measurements were made from median, ulnar, and common pe...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880161107
更新日期:1993-11-01 00:00:00
abstract:INTRODUCTION:Ulnar neuropathy at the elbow (UNE) is a common peripheral compression neuropathy and, in most cases, occurs at 2 sites, the retroepicondylar groove or the cubital tunnel. With regard to a potential therapeutic approach with perineural corticosteroid injection, the aim of this study was to evaluate the dis...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25490
更新日期:2017-08-01 00:00:00
abstract::Toxoplasma gondii encysts in skeletal muscle. Although only rarely found at muscle biopsy, this parasite has previously been regarded as a possible cause of polymyositis. We report a case of biopsy-proven toxoplasmic myositis in a non-HIV-infected patient that led to recognition of idiopathic CD4 lymphocytopenia (ICL)...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.10376
更新日期:2003-06-01 00:00:00
abstract::We propose a comprehensive model of spastic hypertonia based on clinical neurophysiology and validated using experimental data obtained from the pendulum test of the leg in 8 healthy volunteers and 15 spastic patients. This nonlinear computational model includes mechanical parameters and a stretch reflex representatio...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.1196
更新日期:2001-12-01 00:00:00
abstract:INTRODUCTION:Doppler ultrasonography (DU) has recently been shown to be useful in imaging carpal tunnel syndrome (CTS). In this study, we aim to characterize the changes seen after exercise and electrical stimulation. METHODS:Five patients with CTS were recruited with 5 age-matched subjects. DU was used to visualize t...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.23637
更新日期:2013-01-01 00:00:00
abstract::The site of the recording electrode influences the amplitude of the compound muscle action potential (CMAP) and its variation over a length of nerve. The effects of large electrodes on this source of intraindividual variability were assessed. Right median nerves of 20 healthy subjects were studied, and recordings made...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880180110
更新日期:1995-01-01 00:00:00
abstract::Immunologic syndromes are associated with hepatitis B viral (HBV) infection. However, mononeuropathy multiplex (MM), a syndrome in which immune factors may play a role, is rare in acute HBV infection. Few cases of MM associated with HBV infection have been reported. We report a case of acute HBV infection in which MM ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880130304
更新日期:1990-03-01 00:00:00
abstract::The purpose of this study was to evaluate the effects of spinal cord injury (SCI) and functional electrical stimulation (FES) of paralyzed muscles on type IV collagen content and proteins involving its degradation, which is initiated by matrix metalloproteinase (MMP)-2 and -9 and regulated by their tissue inhibitors (...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(200004)23:4<580::aid-mus18
更新日期:2000-04-01 00:00:00
abstract::We report on five patients who presented with unilateral or bilateral hypoplasia of the thenar eminence. X rays of the affected limbs showed varying degrees of malformation and underdevelopment of the thumb phalanges and first metacarpal bone, and of the carpal bones at the base of the thumb, indicating a developmenta...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880020604
更新日期:1979-11-01 00:00:00
abstract:INTRODUCTION:Nemaline myopathy is a rare disorder characterized by skeletal muscle weakness of varying severity and onset, with the presence of nemaline rods on muscle biopsy. Congenital nemaline body myopathy due to mutations in TNNT1 has hitherto only been described as a result of a single founder mutation in patient...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.24885
更新日期:2016-04-01 00:00:00