Abstract:
:The purpose of this study was to evaluate the effects of spinal cord injury (SCI) and functional electrical stimulation (FES) of paralyzed muscles on type IV collagen content and proteins involving its degradation, which is initiated by matrix metalloproteinase (MMP)-2 and -9 and regulated by their tissue inhibitors (TIMPs)-2 and -1. Ten SCI subjects participated in an 18-month program of functional electrical stimulation (FES) of their leg muscles. Needle biopsies were taken from the vastus lateralis muscle before and at various times during the training period, and from able-bodied controls. Type IV collagen concentration was unaltered. ProMMP-2 level of SCI subjects before the training period tended to be higher than able-bodied controls and was significantly above the control level after FES. MMP-9 concentration was unchanged. The results suggest accelerated type IV collagen turnover in skeletal muscle of SCI individuals especially after FES as a part of adaptive process of the muscle.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Koskinen SO,Kjaer M,Mohr T,Sørensen FB,Suuronen T,Takala TEdoi
10.1002/(sici)1097-4598(200004)23:4<580::aid-mus18subject
Has Abstractpub_date
2000-04-01 00:00:00pages
580-9issue
4eissn
0148-639Xissn
1097-4598pii
10.1002/(SICI)1097-4598(200004)23:4<580::AID-MUS18journal_volume
23pub_type
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