Abstract:
:We observed a marked prolongation of the transcranially evoked silent period during continuous intrathecal administration of high doses of the gamma-aminobutyric acid (GABA)B receptor agonist baclofen in a patient with generalized dystonia. Size of motor evoked potentials and central conduction time remained unchanged during intrathecal baclofen administration. The selective prolongation of the silent period during high-dose continuous intrathecal baclofen therapy supports the notion that GABA(B)-ergic intracortical interneurons play a part in the generation of the transcranially evoked silent period.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Siebner HR,Dressnandt J,Auer C,Conrad Bdoi
10.1002/(sici)1097-4598(199809)21:9<1209::aid-mus1subject
Has Abstractpub_date
1998-09-01 00:00:00pages
1209-12issue
9eissn
0148-639Xissn
1097-4598pii
10.1002/(SICI)1097-4598(199809)21:9<1209::AID-MUS1journal_volume
21pub_type
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