Abstract:
:Intramuscular injection of botulinum toxin A is used to treat focal dystonias. Because immunoresistance has been documented in some patients, other molecular forms of the toxin have been evaluated clinically. The present investigation compared the time course and extent of neuromuscular blockade and recovery of botulinum toxin types A and F using an electromyographic monitoring system implanted in the rat hindlimb. For a given dose, the degree and duration of blockade was more complete with type A toxin. Delayed onset of recovery in animals that received high doses of type A toxin allowed time for denervative changes to prevent a full return to baseline, as confirmed histologically. Conversely, animals receiving type F toxin fully recovered within 30 days at all dose levels. The rapid recovery with type F toxin suggested that neuromuscular transmission was restored via the original terminals rather than through functional collateral sprouting. The reversible nature of blockade with this molecular species puts in question its future clinical utility.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Billante CR,Zealear DL,Billante M,Reyes JH,Sant'Anna G,Rodriguez R,Stone RE Jrdoi
10.1002/mus.10213subject
Has Abstractpub_date
2002-09-01 00:00:00pages
395-403issue
3eissn
0148-639Xissn
1097-4598journal_volume
26pub_type
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