Comparison of neuromuscular blockade and recovery with botulinum toxins A and F.

Abstract:

:Intramuscular injection of botulinum toxin A is used to treat focal dystonias. Because immunoresistance has been documented in some patients, other molecular forms of the toxin have been evaluated clinically. The present investigation compared the time course and extent of neuromuscular blockade and recovery of botulinum toxin types A and F using an electromyographic monitoring system implanted in the rat hindlimb. For a given dose, the degree and duration of blockade was more complete with type A toxin. Delayed onset of recovery in animals that received high doses of type A toxin allowed time for denervative changes to prevent a full return to baseline, as confirmed histologically. Conversely, animals receiving type F toxin fully recovered within 30 days at all dose levels. The rapid recovery with type F toxin suggested that neuromuscular transmission was restored via the original terminals rather than through functional collateral sprouting. The reversible nature of blockade with this molecular species puts in question its future clinical utility.

journal_name

Muscle Nerve

journal_title

Muscle & nerve

authors

Billante CR,Zealear DL,Billante M,Reyes JH,Sant'Anna G,Rodriguez R,Stone RE Jr

doi

10.1002/mus.10213

subject

Has Abstract

pub_date

2002-09-01 00:00:00

pages

395-403

issue

3

eissn

0148-639X

issn

1097-4598

journal_volume

26

pub_type

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