Abstract:
:In spite of extensive studies it is unclear whether impaired fasting glucose (IFG) or impaired glucose tolerance (IGT), i.e., impaired glucose metabolism (IGM), causes diabetic sensorimotor polyneuropathy (DSPN) or chronic idiopathic axonal polyneuropathy (CIAP); the results and conclusions vary considerably in different studies. Some studies suggest that IGM is a common and important cause of CIAP, whereas others do not. On reviewing these data, we judge that a considerable degree of this disparity may relate to differences in selection of patients, choice of controls, assessment of chronic glycemic exposure and of diabetic complications, and statistical power. Here we review previous studies, list the reasons that the issue needs further study, and outline a study now in progress to address the question more definitively.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Dyck PJ,Dyck PJ,Klein CJ,Weigand SDdoi
10.1002/mus.20846subject
Has Abstractpub_date
2007-10-01 00:00:00pages
536-41issue
4eissn
0148-639Xissn
1097-4598journal_volume
36pub_type
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