Abstract:
:A quantitative assessment was made of the firing characteristics of repetitive axonal discharges encountered during microneurographic recordings from human peripheral nerves. Spontaneous activity was recorded from 16 single axons using tungsten microelectrodes inserted percutaneously into fascicles of the median or peroneal nerves in normal subjects. These discharges typically consisted of brief bursts of 2-5 spikes occurring at a frequency of 7-10 Hz. Peak instantaneous frequencies usually exceeded 300 Hz. Based on their similarity with spontaneous high-frequency discharges recorded from single axons following nerve damage, ischemia, prolonged electrical stimulation, or hyperventilation, it is concluded that they are generated ectopically at the site of a previous impalement of a nerve fiber. It is suggested that short-term damage to the nerve fiber caused by the microelectrode may allow accumulation of K+ underneath the myelin, triggering an inward flow of K+ and regenerative depolarizations. Alternatively, internodal channels may be exposed following damage to the myelin, resulting in the generation of spontaneous pacemaker potentials and repetitive discharges.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Macefield VGdoi
10.1002/(sici)1097-4598(199804)21:4<461::aid-mus4>subject
Has Abstractpub_date
1998-04-01 00:00:00pages
461-8issue
4eissn
0148-639Xissn
1097-4598pii
10.1002/(SICI)1097-4598(199804)21:4<461::AID-MUS4>journal_volume
21pub_type
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