Abstract:
INTRODUCTION:We determined whether instrumenting timed functional tasks with wireless inertial motion sensors were responsive to facioscapulohumeral muscular dystrophy (FSHD) progression and movement pattern changes. METHODS:Ten individuals who were clinically affected with genetically confirmed FSHD, mean age 54 years (range 42-65), performed an instrumented timed up and go (iTUG) trial at each visit, wearing six wireless inertial sensors. We determined the estimated average monthly slope of progression and 12-month change for temporal and spatial motion variables using a linear mixed effects model. RESULTS:For an average of 20.6 months (range 6.1-34.5), the iTUG duration stayed constant, whereas stride length, stride velocity, and trunk sagittal range of motion changed, indicating poorer performance. Arm swing changed in a compensatory direction toward the normative mean. DISCUSSION:This study provides preliminary evidence that iTUG motion variables could be sensitive to progression in FSHD, but this requires validation in a larger study.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Statland JM,Karanevich A,Bruetsch A,Huisinga Jdoi
10.1002/mus.26681subject
Has Abstractpub_date
2019-11-01 00:00:00pages
590-594issue
5eissn
0148-639Xissn
1097-4598journal_volume
60pub_type
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