Motor neuron disease, lymphoproliferative disease, and bone marrow biopsy.

Abstract:

:Some have suggested that nonfamilial motor neuron disease (MND) may be autoimmune, and the neurological disorder may benefit from immunotherapy. There have been reports of over 30 cases of lymphoproliferative disease (lymphoma, multiple myeloma, Waldenström's macroglobulinemia) with MND, and these patients might he offered immunosuppressive therapy. Bone marrow examination might increase the sensitivity of the diagnostic workup for lymphoma and other lymphoproliferative disorders. We examined the bone marrow in our first evaluation of 161 patients with MND seen at Columbia-Presbyterian Medical Center during 1991-1994. Four of 161 patients (2.5%) had lymphoproliferative disease in the marrow; only 1 of these had a monoclonal paraprotein. Routine bone marrow examination of patients with MND increases the diagnostic yield of lymphoproliferative diseases. The frequency of these bone marrow abnormalities in comparison with a group of age-matched control subjects should be studied further.

journal_name

Muscle Nerve

journal_title

Muscle & nerve

authors

Louis ED,Hanley AE,Brannagan TH,Sherman W,Murphy P,Lange DJ,Trojaborg W,Younger DS,Lovelace RE,Latov N,Rowland LP

doi

10.1002/(SICI)1097-4598(199610)19:10<1334::AID-MUS

subject

Has Abstract

pub_date

1996-10-01 00:00:00

pages

1334-7

issue

10

eissn

0148-639X

issn

1097-4598

pii

10.1002/(SICI)1097-4598(199610)19:10<1334::AID-MUS

journal_volume

19

pub_type

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