Abstract:
:A randomized double-blind therapeutic trial of isaxonine was completed over a 2-year period for 20 ambulant boys with Duchenne muscular dystrophy aged 5 1/2-10 years. The effect of the drug was monitored by measurement of walking times over 28 and 150 ft, motor ability score, MRC score based on 32 muscle groups, and myometry of 7 muscle groups. The drug had no significant effect on the progression of the disease. The trial had statistical power comparable to previous larger-scale multicenter trials. This reflected the low variability in the patients in relation to the magnitude of the overall deterioration. Measurements of muscle force (myometry and MRC score) had much greater statistical power than measurements of function (motor ability score and walking times) as analyzed by our methods. These observations have important implications for the design of future trials.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Heckmatt JZ,Hyde SA,Gabain A,Dubowitz Vdoi
10.1002/mus.880110807subject
Has Abstractpub_date
1988-08-01 00:00:00pages
836-47issue
8eissn
0148-639Xissn
1097-4598journal_volume
11pub_type
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