Abstract:
INTRODUCTION:In this study we evaluated the characteristics of the tibialis anterior muscle after sciatic nerve crush and treatment with low-level laser therapy (LLLT) or the protein from natural latex (P1). METHODS:We studied the following 6 groups of male Wistar rats: control (CG); exposed nerve (EG); injured nerve (IG); injured nerve with LLLT (LG); injured nerve with P1 (PG); and injured nerve with P1 and LLLT (LPG). RESULTS:After 4 weeks, muscle morphology showed improvement in the treated groups; after 8 weeks, the treated groups resembled controls, especially the PG. Morphometry revealed muscle fiber atrophy after nerve injury, with time-dependent recovery. Histochemical analysis revealed increased intermediate fiber area. The PG was more similar to controls with NADH staining, whereas the LPG more closely resembled controls with SDH staining. CONCLUSION:Treatment using only P1 proved most efficient, revealing a negative interaction between P1 and LLLT.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Muniz KL,Dias FJ,Coutinho-Netto J,Calzzani RA,Iyomasa MM,Sousa LG,Santos TT,Teles Vde O,Watanabe IS,Fazan VP,Issa JPdoi
10.1002/mus.24602subject
Has Abstractpub_date
2015-11-01 00:00:00pages
869-75issue
5eissn
0148-639Xissn
1097-4598journal_volume
52pub_type
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