Effects of treadmill training on microvascular remodeling in the rat after spinal cord injury.

Abstract:

INTRODUCTION:The morphological characteristics of skeletal muscles innervated caudal to a spinal cord injury (SCI) undergo dramatic phenotypic and microvascular changes. METHOD:Female Sprague-Dawley rats received a severe contusion at thoracic level 9/10 and were randomly assigned to locomotor training, epidural stimulation, or a combination of the treatment groups (CB). Fiber type composition and capillary distribution were assessed in phenotypically distinct compartments of the tibialis anterior. RESULTS:Spinal cord injury induced a shift in type II fiber phenotype from oxidative to glycolytic (P < 0.05) as well as capillary loss within the oxidative core and glycolytic cortex; the CB treatment best maintained capillary supply within both compartments. DISCUSSION:The angiogenic response of CB training improved capillary distribution across the muscle; capillary distribution became spatially more homogeneous and mean capillary supply area decreased, potentially improving oxygenation. There is an important role for weight-bearing training in maintaining the oxidative phenotype of muscle after SCI. Muscle Nerve 59:370-379, 2019.

journal_name

Muscle Nerve

journal_title

Muscle & nerve

authors

Kissane RWP,Wright O,Al'Joboori YD,Marczak P,Ichiyama RM,Egginton S

doi

10.1002/mus.26379

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

370-379

issue

3

eissn

0148-639X

issn

1097-4598

journal_volume

59

pub_type

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