Interaction of monoclonal antibodies to Torpedo acetylcholine receptor with the receptor of skeletal muscle.

Abstract:

:Several monoclonal antibodies (mcAbs) elicited against the nicotinic acetylcholine receptor (AChR) from Torpedo react also with skeletal muscle AChR. Such mcAbs were used to define antigenic determinants on muscle AChR and to elucidate their effect on muscle AChR functions. Primary chick muscle cultures were used as a model for skeletal muscle. Of the four mcAbs studies only mcAb 5.5, which is directed against the cholinergic site in Torpedo AChR, blocks the binding of alpha-bungarotoxin (alpha-Bgt) to AChR in chick muscle cultures and inhibits carbamylcholine-induced sodium transport in these cells. The interaction of mcAb 5.5 with the cholinergic site on muscle AChR demonstrates the conservation of this site. Two mcAbs, 5.5 and 5.34, each of a different antigenic specificity but both directed against conformation-dependent antigenic determinants, accelerate the degradation of AChR in muscle cultures. From the reactivity of the various mcAbs with Triton-solubilized and membranous AChR it appears that there are some antigenic differences between the detergent solubilized and membranous forms of the receptor.

journal_name

Muscle Nerve

journal_title

Muscle & nerve

authors

Souroujon MC,Mochly-Rosen D,Gordon AS,Fuchs S

doi

10.1002/mus.880060410

subject

Has Abstract

pub_date

1983-05-01 00:00:00

pages

303-11

issue

4

eissn

0148-639X

issn

1097-4598

journal_volume

6

pub_type

杂志文章
  • Electromyography of the anal sphincter: which muscle to examine?

    abstract::Electromyographic examination of the deeper external anal sphincter (EAS) muscle is far more uncomfortable than of the subcutaneous muscle, so we tested the need for its examination. We compared the findings in 85 paired examinations of ipsilateral subcutaneous and deeper EAS muscles in 67 patients with a cauda equina...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.10417

    authors: Podnar S

    更新日期:2003-09-01 00:00:00

  • Conduction block in neuralgic amyotrophy.

    abstract::We describe two cases of neuralgic amyotrophy with electrophysiological evidence of conduction block across the lower trunk of the brachial plexus. Low-output impedance stimulation of the cervical spinal roots in combination with collision was used to accurately demonstrate the conduction block. Complete electrophysio...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.1041

    authors: Watson BV,Nicolle MW,Brown JD

    更新日期:2001-04-01 00:00:00

  • Widespread tissue distribution of multiple mitochondrial DNA deletions in familial mitochondrial myopathy.

    abstract::We used Southern blot analysis and the polymerase chain reaction to analyze the tissue distribution of multiple mitochondrial DNA (mtDNA) deletions in a 45-year-old man with familial mitochondrial myopathy-Southern blots showed two major types of abnormal mtDNA with approximately 4- and 8-kilobase deletions in the ske...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880170707

    authors: Kawashima S,Ohta S,Kagawa Y,Yoshida M,Nishizawa M

    更新日期:1994-07-01 00:00:00

  • Median and ulnar nerve injuries reduce volitional forelimb strength in rats.

    abstract:INTRODUCTION:Peripheral nerve injuries (PNI) are among the leading causes of physical disability in the United States. The majority of injuries occur in the upper extremities, and functional recovery is often limited. Robust animal models are critical first steps for developing effective therapies to restore function a...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.25590

    authors: Meyers EC,Granja R,Solorzano BR,Romero-Ortega M,Kilgard MP,Rennaker RL 2nd,Hays S

    更新日期:2017-12-01 00:00:00

  • Guidelines for ethical behavior relating to clinical practice issues in neuromuscular and electrodiagnostic medicine.

    abstract::The American Association of Neuromuscular & Electrodiagnostic Medicine (AANEM) developed guidelines to formalize the ethical standards that neuromuscular and electrodiagnostic (EDx) physicians should observe in their clinical and scientific activities. Neuromuscular and EDx medicine is a subspecialty of medicine that ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.24910

    authors: Abel NA,De Sousa EA,Govindarajan R,Mayer MP,Simpson DA

    更新日期:2015-12-01 00:00:00

  • Physical function and mobility in children with congenital myotonic dystrophy.

    abstract:INTRODUCTION:Congenital myotonic dystrophy (CDM) occurs when symptoms of myotonic dystrophy present at birth. In this study we evaluated the relationship between physical function, muscle mass, and age to provide an assessment of the disease and help prepare for therapeutic trials. METHODS:CDM participants performed t...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.25482

    authors: Pucillo EM,Dibella DL,Hung M,Bounsanga J,Crockett B,Dixon M,Butterfield RJ,Campbell C,Johnson NE

    更新日期:2017-08-01 00:00:00

  • Anodal sensory nerve action potentials: From physiological understanding to potential clinical applicability.

    abstract:INTRODUCTION:Low-intensity electrical stimuli of digital nerves may generate a double peak potential (DPp), composed of a cathodal (caAP) and an anodal (anAP) potential in orthodromic recordings. METHODS:We studied the effects on caAP and anAP of stimuli of variable intensity, duration, and frequency. We also applied ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.24957

    authors: Leote J,Pereira P,Cabib C,Cipullo F,Valls-Sole J

    更新日期:2016-06-01 00:00:00

  • GNE myopathy in the bedouin population of Kuwait: Genetics, prevalence, and clinical description.

    abstract:INTRODUCTION:GNE myopathy is a rare recessive myopathy caused by mutations in the GNE gene. It is mainly a distal myopathy with relative sparing of the quadriceps muscle. METHODS:Patients with distal myopathies from Kuwait were examined and tested for the Middle Eastern GNE gene founder mutation, p.M743T. Patients wer...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.26337

    authors: Alrohaif H,Pogoryelova O,Al-Ajmi A,Aljeryan LA,Alrashidi NH,Alefasi SA,Urtizberea A,Lochmüller H,Bastaki L

    更新日期:2018-11-01 00:00:00

  • Risk factors for developing post-thymectomy myasthenia gravis in patients with thymoma.

    abstract:INTRODUCTION:Thymectomy is required for the treatment of thymoma-associated myasthenia gravis (MG). However, MG may develop only after thymectomy, a condition known as post-thymectomy MG. This study aimed to investigate the risk factors for post-thymectomy MG in patients with thymoma. METHODS:We retrospectively identi...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.27169

    authors: Kim A,Choi SJ,Kang CH,Lee S,Son H,Kim JA,Shin JY,Kim SM,Hong YH,Sung JJ

    更新日期:2021-01-12 00:00:00

  • Effects of resistance training on force steadiness and common drive.

    abstract::The purpose of this study was to investigate the influence of an 8-week resistance training program on force steadiness and common drive for the vastus lateralis muscle. Eight untrained men performed a resistance training program. Before the program and at the end of each week, the subjects performed a trapezoid isome...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.21836

    authors: Beck TW,Defreitas JM,Stock MS,Dillon MA

    更新日期:2011-02-01 00:00:00

  • Optimal location for eliciting the tibial H-reflex and motor response.

    abstract:INTRODUCTION:Although there are numerous protocols to adjust the amplitude of the Hoffmann reflex (H-reflex) relative to the size of the direct motor response (M-response), the optimal stimulating location has not been described. We sought to determine the optimal positioning of the stimulating cathode when evoking the...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.26308

    authors: Özyurt MG,Shabsog M,Dursun M,Türker KS

    更新日期:2018-12-01 00:00:00

  • Peripheral muscle weakness in RASopathies.

    abstract:INTRODUCTION:RASopathies are a group of genetic conditions due to alterations of the Ras/MAPK pathway. Neurocutaneous findings are hallmark features of the RASopathies, but musculoskeletal abnormalities are also frequent. The objective was to evaluate handgrip strength in the RASopathies. METHODS:Individuals with RASo...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.23324

    authors: Stevenson DA,Allen S,Tidyman WE,Carey JC,Viskochil DH,Stevens A,Hanson H,Sheng X,Thompson BA,Okumura MJ,Reinker K,Johnson B,Rauen KA

    更新日期:2012-09-01 00:00:00

  • Recombinant growth hormone treatment of amyotrophic lateral sclerosis.

    abstract::Based on the known trophic effects of growth hormone (GH) on nerve and muscle 75 patients with ALS were treated for up to 18 months with synthetic human growth hormone (Protropin) or a placebo. The course of ALS was assessed serially using a quantitative (TQNE) neuromuscular and manual exam (MRC) and laboratory chemis...

    journal_title:Muscle & nerve

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1002/mus.880160608

    authors: Smith RA,Melmed S,Sherman B,Frane J,Munsat TL,Festoff BW

    更新日期:1993-06-01 00:00:00

  • The quality of life in genetic neuromuscular disease questionnaire: Rasch validation of the French version.

    abstract:INTRODUCTION:Slowly progressive, genetic neuromuscular diseases (gNMDs) often lead to important motor deficiencies and functional limitations. The Quality of Life in Genetic Neuromuscular Disease Questionnaire (QoL-gNMD) is a new health-related quality-of-life questionnaire developed for these patients. The purpose of ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,多中心研究

    doi:10.1002/mus.25598

    authors: Dany A,Rapin A,Lavrard B,Saoût V,Réveillère C,Bassez G,Tiffreau V,Péréon Y,Sacconi S,Eymard B,Dramé M,Jolly D,Novella JL,Hardouin JB,Boyer FC

    更新日期:2017-12-01 00:00:00

  • Adult human masseter muscle fibers express myosin isozymes characteristic of development.

    abstract::Masseter muscle biopsies were obtained from nine patients undergoing orthognatic surgery or surgery for parotid tumors. A detailed enzyme-histochemical and immunocytochemical study of these muscles was performed using antibodies specific to the various isozymes of the myosin heavy chain (MHC) in order to identify the ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880110614

    authors: Butler-Browne GS,Eriksson PO,Laurent C,Thornell LE

    更新日期:1988-06-01 00:00:00

  • Abductor hallucis false motor points: electrophysiologic mapping and cadaveric dissection.

    abstract::False motor points (FMPs) can occur in intrinsic foot or hand muscles, causing spuriously prolonged distal motor latencies by misrepresenting the compound muscle action potential (CMAP) onset. We investigated the motor point (MP) and possible FMPs in abductor hallucis (AH) by three methods: (1) electrophysiologic mapp...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-4598(199609)19:9<1138::AID-MUS9

    authors: Del Toro DR,Park TA

    更新日期:1996-09-01 00:00:00

  • Postpolio muscular dysfunction: relationships between muscle energy metabolism, subjective symptoms, magnetic resonance imaging, electromyography, and muscle strength.

    abstract::Eleven patients with previous polio were studied. The concentration of energy-related metabolites and energy charge was measured from the vastus lateralis muscle, as was isometric muscle strength of knee extension. Cross-sectional area of the quadriceps femoris muscle was calculated from magnetic resonance imaging. Re...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-4598(199711)20:11<1341::aid-mus

    authors: Nordgren B,Falck B,Stålberg E,Ronquist G,Waldenström A,Ahlström H,Hemmingson A

    更新日期:1997-11-01 00:00:00

  • Electrophysiologic assessment of a median nerve injury in the palm.

    abstract::In median nerve lesions of the hand, electrophysiologic evaluation of the second lumbrical muscle can help to differentiate between lesions of the common digital nerves and the proper digital nerves, as illustrated by this case report. Median nerve conduction studies to the second lumbrical muscle can be performed by ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880090303

    authors: Busis NA,Logigian EL,Shahani BT

    更新日期:1986-03-01 00:00:00

  • Interspike interval analysis in a patient with peripheral nerve hyperexcitability and potassium channel antibodies.

    abstract::Neuromyotonia or Isaacs' syndrome is a rare peripheral nerve hyperexcitability disorder caused by antibodies against potassium channels of myelinated axons. We present the high-density surface electromyographic (EMG) recordings of a patient with fasciculations and cramps due to neuromyotonia. To characterize the time ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.20849

    authors: Kleine BU,Stegeman DF,Drost G,Zwarts MJ

    更新日期:2008-02-01 00:00:00

  • Discrimination of spinal and bulbar muscular atrophy from amyotrophic lateral sclerosis using sensory nerve action potentials.

    abstract:INTRODUCTION:Spinal and bulbar muscular atrophy (SBMA) and amyotrophic lateral sclerosis (ALS) are motor neuron diseases. Sensory impairment is sometimes observed, and electrophysiological involvement has been described in the sensory nerves of SBMA patients. We hypothesized that a sensory nerve conduction study (NCS) ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.22291

    authors: Hama T,Hirayama M,Hara T,Nakamura T,Atsuta N,Banno H,Suzuki K,Katsuno M,Tanaka F,Sobue G

    更新日期:2012-02-01 00:00:00

  • Randomized controlled trial of a clinical decision support system for painful polyneuropathy.

    abstract:INTRODUCTION:Despite the existence of guidelines, painful neuropathy is often inappropriately treated. We sought to determine the effectiveness of a clinical decision support system on guideline-recommended medication use. METHODS:We randomized neurology providers, stratified by subspecialty, to a best practice alert ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/mus.26774

    authors: Reynolds EL,Burke JF,Banerjee M,Callaghan BC

    更新日期:2020-05-01 00:00:00

  • Slow-type C-protein in dystrophic chicken fast pectoralis muscle.

    abstract::C-protein isoform expression in hereditary dystrophic chicken skeletal muscle was compared with that in normal chicken muscle during postnatal development by immunocytochemical and immunoblot methods. In the pectoralis muscle (PM) of both normal and dystrophic chicken, slow- and fast-type C-proteins were coexpressed i...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880100412

    authors: Obinata T,Shinbo K

    更新日期:1987-05-01 00:00:00

  • Morvan's syndrome: clinical, laboratory, and in vitro electrophysiological studies.

    abstract::Morvan's syndrome is a rare disorder characterized by neuromyotonia, hyperhidrosis, and central nervous system dysfunction. We report a patient with features of this syndrome, but who initially presented with breathing difficulties. Concentric needle electromyography showed an abundance of myokymic and neuromyotonic d...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.20081

    authors: Löscher WN,Wanschitz J,Reiners K,Quasthoff S

    更新日期:2004-08-01 00:00:00

  • Ulnar neuropathy and dystonic flexion of the fourth and fifth digits: clinical correlation in musicians.

    abstract::Peripheral nerve lesions are sometimes associated with focal dystonia. We diagnosed ulnar neuropathy in 28 of 73 (40%) cases of occupational cramp in musicians. Focal slowing of ulnar conduction across the elbow was identified in 15 of 19 (79%) patients using the near nerve technique and in 5 of 17 (29%) patients usin...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880190403

    authors: Charness ME,Ross MH,Shefner JM

    更新日期:1996-04-01 00:00:00

  • Velocity recovery function of the compound muscle action potential assessed with doublet and triplet stimulation.

    abstract::Normative values of muscle fiber conduction velocity depend on the conditions in which conduction velocity is measured due to the velocity recovery function (VRF) of muscle fibers. In this study the VRF of the compound muscle action potential (CMAP) was assessed following doublet and triplet stimulation in order to in...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.20801

    authors: Kamavuako EN,Hennings K,Farina D

    更新日期:2007-08-01 00:00:00

  • Electrical impedance myography in the diagnosis of radiculopathy.

    abstract:INTRODUCTION:We sought to determine whether electrical impedance myography (EIM) could serve as a diagnostic procedure for evaluation of radiculopathy. METHODS:Twenty-seven patients with clinically and radiologically diagnosed cervical or lumbosacral radiculopathy who met a "gold standard" definition underwent EIM and...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.23833

    authors: Spieker AJ,Narayanaswami P,Fleming L,Keel JC,Muzin SC,Rutkove SB

    更新日期:2013-11-01 00:00:00

  • Muscular dystrophy in a litter of golden retriever dogs.

    abstract::Clinicopathologic findings from two golden retriever dogs with an inherited, progressive, degenerative muscle disease that were studied until 27 and 40 months of age are described. Initial clinical signs included stilted gait and simultaneous advancement of their pelvic limbs. Further gait restriction and muscle hyper...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880111008

    authors: Kornegay JN,Tuler SM,Miller DM,Levesque DC

    更新日期:1988-10-01 00:00:00

  • Update on immune-mediated therapies for myasthenia gravis.

    abstract::With the exception of thymectomy, immune modulatory treatment strategies and clinical trials in myasthenia gravis over the past 50 y were mainly borrowed from experience in other nonneurologic autoimmune disorders. The current experimental therapy paradigm has significantly changed such that treatments directed agains...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,评审

    doi:10.1002/mus.26919

    authors: Habib AA,Ahmadi Jazi G,Mozaffar T

    更新日期:2020-11-01 00:00:00

  • Macroglossia in advanced amyotrophic lateral sclerosis.

    abstract:INTRODUCTION:An enlarged tongue (macroglossia) has been reported in advanced-stage patients with amyotrophic lateral sclerosis (ALS). METHODS:In this study we examined the prevalence of macroglossia and analyzed clinical correlations in 65 ALS patients on tracheostomy-invasive ventilation (TIV). RESULTS:Macroglossia ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.25058

    authors: Matsuda C,Shimizu T,Nakayama Y,Haraguchi M,Hakuta C,Itagaki Y,Ogura A,Murata K,Taira M,Numayama T,Kinoshita M

    更新日期:2016-09-01 00:00:00

  • Reductions in muscle quality and quantity in chronic inflammatory demyelinating polyneuropathy patients assessed by magnetic resonance imaging.

    abstract:INTRODUCTION:Weakness in patients with chronic inflammatory demyelinating polyneuropathy (CIDP) may be caused by decreases in muscle quantity and quality, but this has not been explored. METHODS:Twelve patients with CIDP (mean age 61 years) and 10 age-matched (mean age 59 years) control subjects were assessed for ankl...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.26159

    authors: Gilmore KJ,Doherty TJ,Kimpinski K,Rice CL

    更新日期:2018-09-01 00:00:00