Macroglossia in advanced amyotrophic lateral sclerosis.

Abstract:

INTRODUCTION:An enlarged tongue (macroglossia) has been reported in advanced-stage patients with amyotrophic lateral sclerosis (ALS). METHODS:In this study we examined the prevalence of macroglossia and analyzed clinical correlations in 65 ALS patients on tracheostomy-invasive ventilation (TIV). RESULTS:Macroglossia was found in 22 patients (33.8%). Compared with those without macroglossia, patients with macroglossia had a younger age of onset, longer duration of disease and TIV use, lower ALS Functional Rating Scale score, higher body mass index, lower energy intake, more severe communication impairment, and lower oral function. Logistic multivariate analysis showed that body mass index (BMI; P = 0.007) and communication impairment (P = 0.029) were significantly correlated with macroglossia. The duration of TIV use was at the cut-off level of significance (P = 0.05). CONCLUSIONS:Macroglossia may be the result of overfeeding and replacement by fat during long-term TIV use in patients with advanced ALS. Muscle Nerve, 2016 Muscle Nerve 54: 386-390, 2016.

journal_name

Muscle Nerve

journal_title

Muscle & nerve

authors

Matsuda C,Shimizu T,Nakayama Y,Haraguchi M,Hakuta C,Itagaki Y,Ogura A,Murata K,Taira M,Numayama T,Kinoshita M

doi

10.1002/mus.25058

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

386-90

issue

3

eissn

0148-639X

issn

1097-4598

journal_volume

54

pub_type

杂志文章
  • Spontaneous and evoked ectopic discharges recorded from single human axons.

    abstract::A quantitative assessment was made of the firing characteristics of repetitive axonal discharges encountered during microneurographic recordings from human peripheral nerves. Spontaneous activity was recorded from 16 single axons using tungsten microelectrodes inserted percutaneously into fascicles of the median or pe...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-4598(199804)21:4<461::aid-mus4>

    authors: Macefield VG

    更新日期:1998-04-01 00:00:00

  • Experimental investigation of muscular neurotization in the rat.

    abstract::Reinnervation of a free muscle graft by nerves from an adjacent intact muscle is called muscular neurotization. This paper investigates the mechanisms and stimuli responsible for muscular neurotization in the rat. Sternohyoid or sternomastoid muscles were transplanted as free muscle grafts to the ventral surface of an...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880100607

    authors: Must R

    更新日期:1987-07-01 00:00:00

  • AAEE case report #19: ischemic monomelic neuropathy.

    abstract::A case study of a 50-year-old man who awakened from aortobifemoral bypass graft surgery with painful burning and numbness of the left foot is reported. Angiography showed embolic occlusion of the left popliteal artery proximal to the knee. Nerve conduction studies performed 1 year after occlusion showed loss or severe...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880121002

    authors: Levin KH

    更新日期:1989-10-01 00:00:00

  • Neuromuscular ultrasound findings in carpal tunnel syndrome with symptoms mainly in the nondominant hand.

    abstract:BACKGROUND:Carpal tunnel syndrome (CTS) may be associated with structural lesions or anatomical variations at the wrist, especially in patients whose symptoms are more severe in, or limited to, the nondominant hand. The aims of this study were to identify the type and frequency of structural abnormalities and anatomica...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.27148

    authors: Chompoopong P,Preston DC

    更新日期:2020-12-21 00:00:00

  • The relation between conduction velocity and axonal length.

    abstract::Motor evoked potentials (MEPs) obtained by electrical root stimulation and F waves were used to examine the proximal nerve conduction velocity (CV) to tibialis anterior (TA), extensor digitorum brevis (EDB), flexor carpi radialis (FCR), and abductor pollicis brevis (APB) muscles in 40 humans. By subtracting motor late...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880181105

    authors: Zwarts MJ,Guechev A

    更新日期:1995-11-01 00:00:00

  • Quantitative measurement of muscle fiber composition in a normal population.

    abstract::To obtain normative muscle morphology data on a healthy population recruited from a population survey, we examined vastus lateralis biopsies from 58 men and 33 women, aged 26-67 years. Biopsies were measured with automated, computer-aided techniques. Data were analyzed according to gender and age, and the influence of...

    journal_title:Muscle & nerve

    pub_type: 临床试验,杂志文章

    doi:10.1002/mus.10373

    authors: Toft I,Lindal S,Bønaa KH,Jenssen T

    更新日期:2003-07-01 00:00:00

  • Reductions in muscle quality and quantity in chronic inflammatory demyelinating polyneuropathy patients assessed by magnetic resonance imaging.

    abstract:INTRODUCTION:Weakness in patients with chronic inflammatory demyelinating polyneuropathy (CIDP) may be caused by decreases in muscle quantity and quality, but this has not been explored. METHODS:Twelve patients with CIDP (mean age 61 years) and 10 age-matched (mean age 59 years) control subjects were assessed for ankl...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.26159

    authors: Gilmore KJ,Doherty TJ,Kimpinski K,Rice CL

    更新日期:2018-09-01 00:00:00

  • Fibrillations in lumbosacral paraspinal muscles of normal subjects.

    abstract::Although paraspinal muscle fibrillations and positive sharp waves (PSWs) are used to help identify neuromuscular disorders, the frequency of these abnormalities in normal subjects is uncertain. We performed lumbosacral paraspinal electromyography in 65 normal subjects. Twenty-seven (42%) had fibrillations and/or PSWs,...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-4598(199810)21:10<1347::aid-mus

    authors: Nardin RA,Raynor EM,Rutkove SB

    更新日期:1998-10-01 00:00:00

  • Multiple descending corticospinal volleys demonstrated by changes of the wrist flexor H-reflex to magnetic motor cortex stimulation in intact human subjects.

    abstract::To study noninvasively multiple descending volleys on alpha motoneurons, we used a 30-50% maximum H-reflex in the wrist flexor muscle conditioned by a subthreshold magnetic stimulus of the contralateral motor cortex as a parameter of motoneuronal excitability in seven neurologically healthy subjects. The time interval...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880160406

    authors: van der Linden C,Bruggeman R

    更新日期:1993-04-01 00:00:00

  • Modeling functional decline over time in sporadic inclusion body myositis.

    abstract:INTRODUCTION:The ability to individualize recommendations or expectations of disease progression based on a patient's unique characteristics has merit for use in sporadic inclusion body myositis (sIBM). METHODS:Fifty-five subjects with sIBM completed a battery of strength and functional outcomes at 2 study visits. The...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.25373

    authors: Alfano LN,Yin H,Dvorchik I,Maus EG,Flanigan KM,Mendell JR,Lowes LP

    更新日期:2017-04-01 00:00:00

  • Surgery for peripheral nerve and brachial plexus injuries or other nerve lesions.

    abstract::The selection of patients who will benefit from peripheral nerve surgery continues to evolve. The evaluation of patients with peripheral nerve problems, and the indications and timing of surgery are reviewed. This includes patients with transections, lesions in continuity, entrapments, tumors, injection injuries, and ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,评审

    doi:10.1002/(sici)1097-4598(200005)23:5<680::aid-mus4>

    authors: Spinner RJ,Kline DG

    更新日期:2000-05-01 00:00:00

  • EMG changes in respiratory and skeletal muscles during isometric contraction under normoxic, hypoxemic, or ischemic conditions.

    abstract::The consequences of general hypoxemia (PaO2 = 51 mmHg) on two muscle groups (adductor pollicis and diaphragm) sustaining 80% maximal isometric voluntary contraction were studied in healthy individuals. For adductor pollicis, contractions were also executed after 10-s or 3-min rest ischemia. Compared to control, i.e., ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880170506

    authors: Badier M,Guillot C,Lagier-Tessonnier F,Jammes Y

    更新日期:1994-05-01 00:00:00

  • Doxorubicin causes diaphragm weakness in murine models of cancer chemotherapy.

    abstract::Doxorubicin is a chemotherapeutic agent prescribed for a variety of tumors. While undergoing treatment, patients exhibit frequent symptoms that suggest respiratory muscle weakness. Cancer patients can receive doxorubicin chemotherapy through either intravenous (IV) or intraperitoneal (IP) injections. We hypothesized t...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.21809

    authors: Gilliam LA,Moylan JS,Callahan LA,Sumandea MP,Reid MB

    更新日期:2011-01-01 00:00:00

  • Further observations on forearm flexor weakness in inclusion body myositis.

    abstract::In order to further characterize and provide a possible mechanism for the asymmetrical involvement of forearm muscles in inclusion body myositis (IBM), we measured isometric hand and pinch grip strength, and forearm muscle girth on 15 IBM patients. Forearm muscle strength and girth were significantly greater on the do...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-4598(199805)21:5<659::aid-mus17

    authors: Felice KJ,Relva GM,Conway SR

    更新日期:1998-05-01 00:00:00

  • Skeletal muscle cell MHC I expression: implications for statin-induced myopathy.

    abstract::Statins can induce necrotizing or inflammatory myopathies in some patients. Increased major histocompatibility complex class I (MHC I) expression has been shown in muscle biopsies of statin-induced myopathy. Therefore, we investigated the effect of statins on the expression of MHC I in muscle cells. Using flow cytomet...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.21479

    authors: Singh P,Kohr D,Kaps M,Blaes F

    更新日期:2010-02-01 00:00:00

  • Sural nerve biopsy studies in Leigh's subacute necrotizing encephalomyelopathy.

    abstract::Peripheral neuropathy marked by reduced nerve conduction velocities was found in four unrelated children, between the ages of 15 months and 9 years, whose autopsies revealed Leigh's subacute necrotizing encephalomyelopathy. Sural nerve biopsies disclosed primary demyelination and remyelination, as well as loss of myel...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880090210

    authors: Goebel HH,Bardosi A,Friede RL,Kohlschütter A,Albani M,Siemes H

    更新日期:1986-02-01 00:00:00

  • Electromyographic and morphological functional compensation in late poliomyelitis.

    abstract::Patients with prior poliomyelitis may experience muscle function deterioration decades after onset of disease. The present study is aimed at describing electromyographic and morphometric evidence of muscular compensation and of on-going muscular instability. Ten subjects 42-62 years of age with onset of polio 25-52 ye...

    journal_title:Muscle & nerve

    pub_type: 临床试验,杂志文章

    doi:10.1002/mus.880130214

    authors: Einarsson G,Grimby G,Stålberg E

    更新日期:1990-02-01 00:00:00

  • A mechanistic approach to the myotonic syndromes.

    abstract::The electrical characteristics of myotonia in skeletal muscle appear remarkably similar in a variety of natural disorders and animal models. Recent experimental work has made it clear, however, that the pathophysiologic mechanisms underlying these myotonic discharges can be quite different. A mechanistic classificatio...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,评审

    doi:

    authors: Barchi RL

    更新日期:1982-01-01 00:00:00

  • Anterograde transport of leukemia inhibitory factor within transected sciatic nerves.

    abstract::Disappointing functional recovery following peripheral nerve repair can be improved by neurotrophic growth factors. Leukemia inhibitory factor (LIF) is unique in that it has independent neurotrophic and myotrophic actions. The aim of this study was to explain this finding by establishing the existence of anterograde a...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-4598(199901)22:1<78::aid-mus12>

    authors: Bennett TM,Dowsing BJ,Austin L,Messina A,Nicola NA,Morrison WA

    更新日期:1999-01-01 00:00:00

  • Skeletal muscle response to tenotomy.

    abstract::Tenotomy is a commonly encountered clinical entity, whether traumatic or iatrogenic. This article reviews the response of skeletal muscle to tenotomy. The changes are subdivided into molecular, architectural, and functional categories. Architectural disruption of the muscle includes myofiber disorganization, central c...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,评审

    doi:10.1002/(sici)1097-4598(200006)23:6<851::aid-mus3>

    authors: Jamali AA,Afshar P,Abrams RA,Lieber RL

    更新日期:2000-06-01 00:00:00

  • Familial amyloid polyneuropathy in Taiwan: identification of transthyretin variant (Leu55-->Pro).

    abstract::We report a family with familial amyloid polyneuropathy (FAP), showing an early-onset and a fatal outcome before age 30. Transthyretin (TTR) gene analysis showed one point mutation (T-->C change) in the second base of codon 55, and the corresponding amino acid substitution of proline (Pro) for leucine (Leu) was confir...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880170611

    authors: Yamamoto K,Hsu SP,Yoshida K,Ikeda S,Nakazato M,Shiomi K,Cheng SY,Furihata K,Ueno I,Yanagisawa N

    更新日期:1994-06-01 00:00:00

  • Time and frequency domain analysis of acoustic signals from a human muscle.

    abstract::We wished to determine whether evoked force output from a human muscle could be inferred from the amplitude and the frequency of evoked muscular sounds. Sounds from adductor pollicis were recorded with a microphone and compared to evoked force changes produced by varying the intensity of nerve stimulation or of volunt...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-4598(199708)20:8<991::aid-mus9>

    authors: Chen D,Durand LG,Bellemare F

    更新日期:1997-08-01 00:00:00

  • Skin-derived precursor Schwann cell myelination capacity in focal tibial demyelination.

    abstract:INTRODUCTION:Skin-derived precursor cells (SKPs) are neural crest progenitor cells that can attain a Schwann cell-like phenotype through in vitro techniques (SKP-SCs). We hypothesized that SKP-SCs could produce mature myelin and, in doing so, facilitate the recovery of a focal demyelination injury. METHODS:We unilater...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.24136

    authors: Grochmal J,Dhaliwal S,Stys PK,van Minnen J,Midha R

    更新日期:2014-08-01 00:00:00

  • Effects of extracorporeal shock-wave lithotripsy directed at the parotid gland on oxidative stress parameters and some trace element levels in facial nerve of rats.

    abstract:INTRODUCTION:This study was designed to assess the effect of extracorporeal shock-wave lithotripsy (ESWL) exposure of the parotid gland on oxidative stress and some trace element levels in the facial nerves of rats. METHODS:Twelve male Wistar albino rats were divided into two groups, each consisting of 6 animals. The ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.22326

    authors: Kavak S,Garca MF,Gecit I,Meral I,Cengiz N,Demir H

    更新日期:2012-04-01 00:00:00

  • Lymphoma and peripheral neuropathy: a clinical review.

    abstract::Lymphoma occasionally affects the peripheral nervous system. When it does, the diagnosis can be elusive since many patients present without known lymphoma. Most peripheral nerve complications are due to non-Hodgkin's lymphoma (NHL), which infiltrates nerves causing axonal damage. This disorder can affect nerve roots a...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,评审

    doi:10.1002/mus.20163

    authors: Kelly JJ,Karcher DS

    更新日期:2005-03-01 00:00:00

  • A novel electrodiagnostic assessment of the laryngeal closure reflex.

    abstract:INTRODUCTION:We describe a novel, clinically applicable conduction study of the laryngeal nerves. METHODS:Seventeen normal volunteer subjects were included. Activation of the sensory territory of the superior laryngeal nerve was performed by administration of low level brief electrical stimuli. The laryngeal closure r...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.23544

    authors: Carey B,Sulica L,Wu A,Branski R

    更新日期:2013-03-01 00:00:00

  • Transient focal conduction block following experimental occlusion of the vasa nervorum.

    abstract::Injection of low-dose arachidonic acid into the rat femoral artery occludes the vasa nervorum of the tibial nerve and produces focal and generalized ischemia with transient effects on nerve conduction. Across a severely ischemic segment of the proximal tibial nerve there is a marked fall in amplitude of the compound m...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880090411

    authors: Parry GJ,Linn DJ

    更新日期:1986-05-01 00:00:00

  • GNE myopathy in the bedouin population of Kuwait: Genetics, prevalence, and clinical description.

    abstract:INTRODUCTION:GNE myopathy is a rare recessive myopathy caused by mutations in the GNE gene. It is mainly a distal myopathy with relative sparing of the quadriceps muscle. METHODS:Patients with distal myopathies from Kuwait were examined and tested for the Middle Eastern GNE gene founder mutation, p.M743T. Patients wer...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.26337

    authors: Alrohaif H,Pogoryelova O,Al-Ajmi A,Aljeryan LA,Alrashidi NH,Alefasi SA,Urtizberea A,Lochmüller H,Bastaki L

    更新日期:2018-11-01 00:00:00

  • Comparison of analysis approaches for phase III clinical trials in amyotrophic lateral sclerosis.

    abstract:INTRODUCTION:In this study we explore several methods for incorporating survival information in the analysis of Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS) scores. METHODS:ALSFRS scores and patient survival times were simulated based on estimates from a recent clinical trial. Six analysis approaches...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.23392

    authors: Healy BC,Schoenfeld D

    更新日期:2012-10-01 00:00:00

  • Influence of body mass index on median nerve function, carpal canal pressure, and cross-sectional area of the median nerve.

    abstract::Obese individuals have slowed conduction in the median nerve across the wrist, but the mechanism for this is not established. This case-control study of 27 obese subjects and 16 thin subjects was designed to test the hypothesis that obese individuals have higher carpal canal pressures and more median nerve swelling th...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.20125

    authors: Werner RA,Jacobson JA,Jamadar DA

    更新日期:2004-10-01 00:00:00