Abstract:
:Peripheral neuropathy marked by reduced nerve conduction velocities was found in four unrelated children, between the ages of 15 months and 9 years, whose autopsies revealed Leigh's subacute necrotizing encephalomyelopathy. Sural nerve biopsies disclosed primary demyelination and remyelination, as well as loss of myelinated and unmyelinated axons. The use of morphometric and electron microscopic studies shows that these techniques may reveal peripheral neuropathy in Leigh's disease more often than light microscopic methods alone.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Goebel HH,Bardosi A,Friede RL,Kohlschütter A,Albani M,Siemes Hdoi
10.1002/mus.880090210subject
Has Abstractpub_date
1986-02-01 00:00:00pages
165-73issue
2eissn
0148-639Xissn
1097-4598journal_volume
9pub_type
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