Correlation of single-breath count test and neck flexor muscle strength with spirometry in myasthenia gravis.

Abstract:

INTRODUCTION:Although formal spirometry is the gold standard for monitoring respiratory function in patients with myasthenia gravis (MG), such testing is often delayed or unavailable. There is a need for a simple bedside test that can accurately measure respiratory function. METHODS:We conducted a prospective, cross-sectional, single-blind study in adults with acetylcholine receptor antibody positive MG. Participants performed the single breath count test (SBCT) and underwent manual muscle strength testing, and a respiratory therapist performed spirometry blinded to SBCT and strength results. RESULTS:Thirty-one patients, aged 57 ± 19 years participated. SBCT showed significant correlations with forced vital capacity (FVC), negative inspiratory force, and neck flexor strength (P < 0.01). FVC showed significant correlation with neck flexor strength (P = 0.02) but no correlation with shoulder abductor strength. CONCLUSIONS:These data suggest that the SBCT and neck flexor strength testing are valuable tools for bedside assessment of respiratory function in MG patients.

journal_name

Muscle Nerve

journal_title

Muscle & nerve

authors

Elsheikh B,Arnold WD,Gharibshahi S,Reynolds J,Freimer M,Kissel JT

doi

10.1002/mus.24929

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

134-6

issue

1

eissn

0148-639X

issn

1097-4598

journal_volume

53

pub_type

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