Abstract:
INTRODUCTION:Although formal spirometry is the gold standard for monitoring respiratory function in patients with myasthenia gravis (MG), such testing is often delayed or unavailable. There is a need for a simple bedside test that can accurately measure respiratory function. METHODS:We conducted a prospective, cross-sectional, single-blind study in adults with acetylcholine receptor antibody positive MG. Participants performed the single breath count test (SBCT) and underwent manual muscle strength testing, and a respiratory therapist performed spirometry blinded to SBCT and strength results. RESULTS:Thirty-one patients, aged 57 ± 19 years participated. SBCT showed significant correlations with forced vital capacity (FVC), negative inspiratory force, and neck flexor strength (P < 0.01). FVC showed significant correlation with neck flexor strength (P = 0.02) but no correlation with shoulder abductor strength. CONCLUSIONS:These data suggest that the SBCT and neck flexor strength testing are valuable tools for bedside assessment of respiratory function in MG patients.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Elsheikh B,Arnold WD,Gharibshahi S,Reynolds J,Freimer M,Kissel JTdoi
10.1002/mus.24929subject
Has Abstractpub_date
2016-01-01 00:00:00pages
134-6issue
1eissn
0148-639Xissn
1097-4598journal_volume
53pub_type
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