Abstract:
INTRODUCTION:Few data are available to quantify the risks and benefits of microvascular decompression (MVD) in elderly patients with hemifacial spasm. METHODS:Twenty-seven patients >65 years of age and 104 younger patients who underwent MVD for hemifacial spasm (HFS) over a 3-year period were analyzed retrospectively and compared. RESULTS:Twenty-six (96.3%) elderly patients and 93 of 104 (89.4%) young patients reported a spasm-free status at a mean follow-up of 26.5 months after MVD. No significant difference in spasm-free status was noted. Cranial nerve complications and other major complications were compared, with no significant differences observed. CONCLUSIONS:Although this study does not offer definitive inclusion or exclusion criteria or clearly establish the safety of MVD for HFS in the elderly, our experience suggests that many elderly patients with HFS can undergo MVD safely, with outcomes and risk profiles similar to those of younger patients.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Sekula RF Jr,Frederickson AM,Arnone GD,Quigley MR,Hallett Mdoi
10.1002/mus.23800subject
Has Abstractpub_date
2013-11-01 00:00:00pages
770-6issue
5eissn
0148-639Xissn
1097-4598journal_volume
48pub_type
杂志文章相关文献
MUSCLE & NERVE文献大全abstract:INTRODUCTION:Duchenne muscular dystrophy (DMD) is a degenerative disease of skeletal, respiratory, and cardiac muscles caused by defects in the dystrophin gene. More recently, brain involvement has been verified. Mitochondrial dysfunction and oxidative stress may underlie the pathophysiology of DMD. In this study we ev...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.24704
更新日期:2016-01-01 00:00:00
abstract:INTRODUCTION:Low-intensity electrical stimuli of digital nerves may generate a double peak potential (DPp), composed of a cathodal (caAP) and an anodal (anAP) potential in orthodromic recordings. METHODS:We studied the effects on caAP and anAP of stimuli of variable intensity, duration, and frequency. We also applied ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.24957
更新日期:2016-06-01 00:00:00
abstract:INTRODUCTION:Slowly progressive, genetic neuromuscular diseases (gNMDs) often lead to important motor deficiencies and functional limitations. The Quality of Life in Genetic Neuromuscular Disease Questionnaire (QoL-gNMD) is a new health-related quality-of-life questionnaire developed for these patients. The purpose of ...
journal_title:Muscle & nerve
pub_type: 杂志文章,多中心研究
doi:10.1002/mus.25598
更新日期:2017-12-01 00:00:00
abstract:INTRODUCTION:We sought to define the whole-body MRI (WB-MRI) fingerprint of muscle involvement in pediatric LMNA-related dystrophy (LMNA-RD) and to compare it with SEPN1-related myopathy (SEPN1-RM). METHODS:Signal abnormality and atrophy in 109 muscles were scored by semiquantitative scales in 8 children with LMNA-RD ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25018
更新日期:2016-08-01 00:00:00
abstract::If anti-GM1 antibody plays a role in the axonal damage in Guillain-Barré syndrome, the common entrapment sites may be preferentially involved with evidence of axonal dysfunction. To assess this hypothesis, we studied nerve conduction across the cubital tunnel in 44 patients. Abnormal amplitude reduction of compound mu...
journal_title:Muscle & nerve
pub_type: 临床试验,杂志文章
doi:10.1002/(sici)1097-4598(199907)22:7<840::aid-mus5>
更新日期:1999-07-01 00:00:00
abstract::As applied to skeletal muscle, stem cell therapy is a reincarnation of myoblast transfer therapy that has resulted from recent advances in the cell biology of skeletal muscle. Both strategies envisage the reconstruction of damaged muscle from its precursors, but stem cell therapy employs precursors that are earlier in...
journal_title:Muscle & nerve
pub_type: 杂志文章,评审
doi:10.1002/mus.10243
更新日期:2003-02-01 00:00:00
abstract::We report three patients with inflammatory myopathy who presented clinically with weakness and wasting of only one limb. The myopathy progressed over 6 months and 5 years, respectively, in two patients and was stable after 8 years in the third patient. One patient had a skin rash. Serum CK was elevated in the two pati...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880070210
更新日期:1984-02-01 00:00:00
abstract:INTRODUCTION:Despite the existence of guidelines, painful neuropathy is often inappropriately treated. We sought to determine the effectiveness of a clinical decision support system on guideline-recommended medication use. METHODS:We randomized neurology providers, stratified by subspecialty, to a best practice alert ...
journal_title:Muscle & nerve
pub_type: 杂志文章,随机对照试验
doi:10.1002/mus.26774
更新日期:2020-05-01 00:00:00
abstract::Although paraspinal muscle fibrillations and positive sharp waves (PSWs) are used to help identify neuromuscular disorders, the frequency of these abnormalities in normal subjects is uncertain. We performed lumbosacral paraspinal electromyography in 65 normal subjects. Twenty-seven (42%) had fibrillations and/or PSWs,...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(199810)21:10<1347::aid-mus
更新日期:1998-10-01 00:00:00
abstract::We have previously demonstrated that patients with mitochondrial myopathies can benefit from short-term aerobic exercise training. In this study, we compared the responses to short-term aerobic training of patients with mitochondrial myopathies, patients with nonmetabolic myopathies, and sedentary normal subjects. Tra...
journal_title:Muscle & nerve
pub_type: 临床试验,杂志文章
doi:10.1002/(sici)1097-4598(199909)22:9<1239::aid-mus1
更新日期:1999-09-01 00:00:00
abstract:INTRODUCTION:Repetitive loading of the low back tissues induces tension relaxation with a corresponding variation in the myoelectric response of the neuromuscular system, which may influence low back health. The purpose of this study was to observe trunk muscle activities before and after a passive cyclic trunk flexion...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.22154
更新日期:2011-11-01 00:00:00
abstract:INTRODUCTION:The ability to individualize recommendations or expectations of disease progression based on a patient's unique characteristics has merit for use in sporadic inclusion body myositis (sIBM). METHODS:Fifty-five subjects with sIBM completed a battery of strength and functional outcomes at 2 study visits. The...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25373
更新日期:2017-04-01 00:00:00
abstract:INTRODUCTION:Transitioning from adolescence to adulthood can be problematic for individuals with rare disabilities such as muscular dystrophy (MD). METHODS:We identified a cohort of 220 individuals with MD and 440 matched comparison individuals and measured emergency room (ER) and inpatient (IP) encounters for the yea...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.24599
更新日期:2015-11-01 00:00:00
abstract:INTRODUCTION:Piriformis muscle syndrome (PS) is a disorder encompassing a constellation of symptoms, including buttock and hip pain. In this study we aimed to assess the value of ultrasound (US) in the diagnosis of PS. METHODS:Thirty-three clinically diagnosed PS patients and 26 healthy volunteers underwent a clinical...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.26418
更新日期:2019-04-01 00:00:00
abstract:INTRODUCTION:Eosinophilic fasciitis (EF) is a rare disorder that can present with muscle symptoms that mimic other neuromuscular diseases. METHODS:We report the case of a 43-year-old woman with chronic muscle aches, tightness, and stiffness with hypertrophied, well-defined muscles despite physical inactivity, and thic...
journal_title:Muscle & nerve
pub_type:
doi:10.1002/mus.25492
更新日期:2017-09-01 00:00:00
abstract::Limb-girdle muscular dystrophy 2D (LGMD2D) is caused by mutations in the alpha-sarcoglycan gene (SGCA). The most frequently reported mutation, 229CGC>TGC (R77C) in exon 3 of SGCA, results in the substitution of arginine by cysteine. We present here the clinical, immunohistochemical, and genetic data of 11 Finnish pati...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.20267
更新日期:2005-02-01 00:00:00
abstract::Clinicians who use electromyographic (EMG) signals to help determine the presence or absence of abnormality in a muscle often, with varying degrees of success, evaluate sets of motor unit potentials (MUPs) qualitatively and/or quantitatively to characterize the muscle in a clinically meaningful way. The resulting musc...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21456
更新日期:2010-01-01 00:00:00
abstract::Acquired neuromyotonia is characterized by hyperexcitability of motor nerves resulting in continuous muscle fiber activity. It occurs most often as a paraneoplastic syndrome in patients with cancers of the immune system. Antibodies against voltage-gated potassium channels (VGKCs) have been detected in some patients. P...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.1078
更新日期:2001-06-01 00:00:00
abstract::The pathophysiology of hepatic neuropathy is poorly understood, but membrane depolarization due to a toxic inhibition of oxidative metabolism has been proposed. We investigated the relationship between nerve excitability properties, nerve dysfunction, and liver function in 11 pretransplant patients, the majority of wh...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.20765
更新日期:2007-06-01 00:00:00
abstract::On magnetic resonance (MR) imaging of the brachial plexus increased signal intensity and swelling of the brachial plexus has been found in chronic inflammatory demyelinating polyneuropathy (CIDP). Whether these proximal abnormalities are also present in the distal polyneuropathy associated with monoclonal gammopathy i...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.1149
更新日期:2001-10-01 00:00:00
abstract::Heterozygous mutations in the Berardinelli-Seip congenital lipodystrophy (BSCL2) gene have been associated with different clinical phenotypes including Silver syndrome/spastic paraplegia 17, distal hereditary motor neuropathy type V, and Charcot-Marie-Tooth disease type 2 (CMT2) with predominant hand involvement. We s...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21734
更新日期:2010-09-01 00:00:00
abstract::Exercise intolerance and undue fatigue are common complaints in patients with Charcot-Marie-Tooth (CMT) disease. Reduced physical ability is due directly to the disease, but it is also due to physical deconditioning. The aim of this study was to test whether 24 weeks of interval-training exercise (ITE) cycling can sig...
journal_title:Muscle & nerve
pub_type: 临床试验,杂志文章
doi:10.1002/mus.20959
更新日期:2008-05-01 00:00:00
abstract::Hereditary neuropathy with liability to pressure palsy (HNPP) is typified as isolated nerve palsies caused by trivial compression or trauma. It rarely presents in two extremities and even more infrequently affects all four limbs simultaneously. We present a patient who concurrently experienced right shoulder, left han...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(200006)23:6<979::aid-mus23
更新日期:2000-06-01 00:00:00
abstract::To clarify the molecular nature of the pathogenesis in X-linked Emery-Dreifuss muscular dystrophy (EDMD), we monitored the expression of 2400 genes in control and EDMD fibroblasts by using complementary DNA (cDNA) microarray techniques. A total of 60 genes whose expression was altered in EDMD fibroblasts when compared...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.10085
更新日期:2002-06-01 00:00:00
abstract::We compared the compound motor action potentials (CMAPs) evoked in the biceps, triceps, and abductor digiti minimi (ADM) muscles by conventional electrical stimulation at Erb's point (EP), and by magnetic coil stimulation of the supraclavicular region in 11 normal subjects. We found that magnetic coil stimulation was ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880150509
更新日期:1992-05-01 00:00:00
abstract::Sera of patients with myasthenia gravis (MG) contain anti-acetylcholine receptor (AChR) IgG antibodies (Ab) which have different antigenic specificities. Three Ab types were detected: (1) MG-I, which forms immune complexes with AChR; (2) MG-C, which decreases binding of AChR to concanavalin A; and MG-B, which blocks a...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880040105
更新日期:1981-01-01 00:00:00
abstract::Voluntary and stimulation single-fiber electromyography were performed in the extensor digitorum communis muscle of 15 myasthenic patients. The increase in mean and individual mean consecutive difference as well as the proportion of blocking in the volitional activation were greater than in the stimulation method. The...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(199808)21:8<1081::aid-mus1
更新日期:1998-08-01 00:00:00
abstract::Electrodiagnostic studies were analyzed in patients with neuropathy associated with IgM monoclonal proteins, 7 with anti-myelin associated glycoprotein reactivity (MAG) and 7 nonreactive to MAG. The findings were distinctly different in the two groups. The electrodiagnostic studies of all the MAG-reactive patients had...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880131205
更新日期:1990-12-01 00:00:00
abstract::Many patients with the limb-girdle variant of congenital myasthenic syndrome (CMS) possess mutations in the human Dok-7 gene (DOK7). We identified six unrelated CMS patients with DOK7 mutations. Two patients, one mildly and the other moderately affected, were homozygous for the previously described 1263insC mutation. ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.20944
更新日期:2008-04-01 00:00:00
abstract::This study contrasts the developmental patterns of expression of 2 subtypes of the voltage-dependent sodium channel in rat muscle that are differentiated by their immunoreactivity with monoclonal antibodies raised to the purified muscle sodium channel protein. One subtype is found in the transverse tubular (T) system ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880140209
更新日期:1991-02-01 00:00:00