Changes in intramuscular collagen and fibronectin in denervation atrophy.

Abstract:

:The distribution of collagen types I, III, and V and fibronectin was investigated by means of immunofluorescent techniques in denervated and normal rat skeletal muscle. During a period of 28 days, a distinct atrophy developed in the denervated gastrocnemius muscle and was accompanied by an increase in types I and III collagen in the endomysium and perimysium. The amount of type V collagen showed little change, whereas fibronectin increase closely parallelled types I and III collagen. The results indicate that denervation atrophy in muscles is accompanied by striking fibrotic changes due to mesenchymal types I and III collagen.

journal_name

Muscle Nerve

journal_title

Muscle & nerve

authors

Salonen V,Lehto M,Kalimo M,Penttinen R,Aro H

doi

10.1002/mus.880080208

subject

Has Abstract

pub_date

1985-02-01 00:00:00

pages

125-31

issue

2

eissn

0148-639X

issn

1097-4598

journal_volume

8

pub_type

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