Early diagnosis of n-hexane-caused neuropathy.

Abstract:

:n-Hexane neuropathy was studied in 20 workers exposed for prolonged periods to this solvent, and with urinary 2,5-hexanedione concentrations exceeding the biological exposure index recommended by the American Conference of Governmental Industrial Hygienists (5 mg/L) with a mean of 11.02 mg/L (range 5.3-24.2 mg/L). Although neurological examination did not detect significant anomalies in any of the patients, and the conduction velocity and F waves of all the nerves tested were normal, neurographic studies revealed significant differences in the amplitude of sensory nerve action potentials (SNAP) recorded from the sural (mean 14.0 microV), median (mean 17.3 microV), and ulnar (mean 7.9 microV) nerves when compared with normal values from healthy adults of the same age range, examined under identical conditions. The amplitude of the SNAP in sural and median nerves correlated significantly with the number of years worked. The notable decrease in mean amplitude of the SNAP appeared to reflect the primary neurotoxic effects of 2,5-hexanedione.

journal_name

Muscle Nerve

journal_title

Muscle & nerve

authors

Pastore C,Marhuenda D,Marti J,Cardona A

doi

10.1002/mus.880170904

subject

Has Abstract

pub_date

1994-09-01 00:00:00

pages

981-6

issue

9

eissn

0148-639X

issn

1097-4598

journal_volume

17

pub_type

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