Abstract:
:A low conductance calcium-activated K+ channel is thought to regulate the rate of firing of several excitable cells. In skeletal muscle the expression of this channel is under nerve control. Previously, we reported that axonal flow blockade of rat nerves, induced by colchicine, caused a transient increase in muscle apamin receptors, determined by 125I-apamin binding to membrane fractions. The increase in apamin receptors was correlated with repetitive discharges resembling myotonic potentials in the electromyogram, that were blockable by apamin. Here we show that the increase in muscle apamin receptors and the alteration of the electromyogram are followed closely by a slowing of the twitch relaxation, that in turn, is decreased by apamin. Furthermore, the presence of myotonic-like alterations in the electromyogram and a slowing of muscle relaxation when muscle apamin receptors are increased suggests that these channels may participate, among other factors, in the generation of some kinds of myotonia.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Vergara C,Ramírez B,Behrens MIdoi
10.1002/mus.880160908subject
Has Abstractpub_date
1993-09-01 00:00:00pages
935-40issue
9eissn
0148-639Xissn
1097-4598journal_volume
16pub_type
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