Abstract:
INTRODUCTION:We aimed to investigate whether sonographic peripheral cross-sectional nerve area (CSA) and progranulin (PGRN), a neuritic growth factor, are related to each other and whether they interact to predict clinical and paraclinical measures in amyotrophic lateral sclerosis (ALS). METHODS:We included 55 ALS patients who had forearm median and ulnar nerve CSA, cerebrospinal fluid (CSF) PGRN, and serum PGRN measures available. CSF PGRN was normalized against the CSF / serum albumin ratio (Qalb ). Using age, sex, height, and weight adjusted general linear models, we examined CSA × CSF PGRN interaction effects on various measures. RESULTS:There was a medium-effect size inverse relationship between CSA and CSF PGRN, but not between CSA and serum PGRN. Lower CSA values together with higher CSF PGRN levels were linked to smaller motor amplitudes. DISCUSSION:In ALS, the constellation of peripheral nerve atrophy together with higher CSF PGRN levels indicates pronounced axonal damage. Muscle Nerve 57: 273-278, 2018.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Schreiber S,Debska-Vielhaber G,Abdulla S,Machts J,Schreiber F,Kropf S,KÖrtvelyessy P,KÖrner S,Kollewe K,Petri S,Dengler R,Kunz WS,Nestor PJ,Vielhaber Sdoi
10.1002/mus.25682subject
Has Abstractpub_date
2018-02-01 00:00:00pages
273-278issue
2eissn
0148-639Xissn
1097-4598journal_volume
57pub_type
杂志文章相关文献
MUSCLE & NERVE文献大全abstract::A method for quantifying shape variability, the jiggle, or motor unit potentials (MUPs) recorded with conventional EMG electrodes is presented. Amplitude variability at each point of time of the MUP was analyzed. Two new parameters are proposed: the normalized value of the consecutive amplitude differences (CAD), and ...
journal_title:Muscle & nerve
pub_type: 临床试验,杂志文章
doi:10.1002/mus.880171003
更新日期:1994-10-01 00:00:00
abstract::Mutations in the sarcoglycan (SG) genes cause a subset of limb-girdle muscular dystrophies (LGMD). We report a Spanish patient with progressive LGMD exhibiting an almost isolated loss of gamma-SG and a homozygous Delta521-T mutation in the gamma-SG gene. These results suggest that isolated loss of gamma-SG might remai...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/1097-4598(200103)24:3<421::aid-mus1016>3.0
更新日期:2001-03-01 00:00:00
abstract:INTRODUCTION:We sought to determine whether electrical impedance myography (EIM) could serve as a diagnostic procedure for evaluation of radiculopathy. METHODS:Twenty-seven patients with clinically and radiologically diagnosed cervical or lumbosacral radiculopathy who met a "gold standard" definition underwent EIM and...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.23833
更新日期:2013-11-01 00:00:00
abstract:INTRODUCTION:The p.A1156T mutation alters the function of the voltage-gated sodium channel Nav1.4 on the muscle sarcolemma, causing a channelopathy without overt myotonia or periodic paralysis but with myalgic pain. METHODS:A postal survey was conducted to assess the prevalence and characteristics of pain and related ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.26050
更新日期:2018-06-01 00:00:00
abstract:INTRODUCTION:Evaluation of phrenic neuropathy (PN) with phrenic nerve conduction studies (PNCS) is associated with false negatives. Visualization of diaphragmatic muscle twitch with diaphragm ultrasound (DUS) when performing PNCS may help to solve this problem. METHODS:We performed bilateral, simultaneous DUS-PNCS in ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.24059
更新日期:2014-05-01 00:00:00
abstract::We report a patient initially diagnosed as having ocular myasthenia gravis who showed progressive ophthalmoparesis and pseudoblepharospasm together with positive acetylcholine receptor antibodies. Repeated evaluation with high-frequency repetitive stimulation revealed an incremental response and elevated titers of ant...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(199912)22:12<1727::aid-mus
更新日期:1999-12-01 00:00:00
abstract:INTRODUCTION:Tarsal tunnel syndrome (TTS) arises from tibial nerve damage under the flexor retinaculum of the fibro-osseus tunnel at the medial malleolus. It is notoriously difficult to diagnose, as many other foot pathologies result in a similar clinical picture. We examined the additional value of nerve ultrasound in...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.24963
更新日期:2016-06-01 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a debilitating neurodegenerative disorder with complex biology and significant clinical heterogeneity. Many preclinical and early phase ALS clinical trials have yielded promising results that could not be replicated in larger phase 3 confirmatory trials. One reason for the lack o...
journal_title:Muscle & nerve
pub_type: 杂志文章,评审
doi:10.1002/mus.26801
更新日期:2020-08-01 00:00:00
abstract::The selection of patients who will benefit from peripheral nerve surgery continues to evolve. The evaluation of patients with peripheral nerve problems, and the indications and timing of surgery are reviewed. This includes patients with transections, lesions in continuity, entrapments, tumors, injection injuries, and ...
journal_title:Muscle & nerve
pub_type: 杂志文章,评审
doi:10.1002/(sici)1097-4598(200005)23:5<680::aid-mus4>
更新日期:2000-05-01 00:00:00
abstract::The purpose of the study was to identify factors that could predict differences among individuals in the time to failure of a submaximal contraction. Twenty subjects (10 men, 25+/-6 years) supported an inertial load equivalent to 20% of the maximal voluntary contraction (MVC) force with the elbow flexor muscles for as...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.20752
更新日期:2007-05-01 00:00:00
abstract::Three well-characterized antimyosin heavy chain monoclonal antibodies (McAbs) were used as immunocytochemical reagents to study myosin isoform expression in relationship to adenosine triphosphatase (ATPase) defined fiber types in human muscle. The biopsy specimens were from patients with neurogenic muscle disease whos...
journal_title:Muscle & nerve
pub_type: 杂志文章,评审
doi:10.1002/mus.880120809
更新日期:1989-08-01 00:00:00
abstract::Sucrose gap and intra-axonal recording techniques were used to identify the types of ion channels and inward rectification that are present in regenerated axons of adult (greater than 8 weeks) rat sciatic nerve after crush injury. In sucrose gap recordings, 4-aminopyridine (4-AP) led to slight broadening of the compou...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880140707
更新日期:1991-07-01 00:00:00
abstract::We compared the compound motor action potentials (CMAPs) evoked in the biceps, triceps, and abductor digiti minimi (ADM) muscles by conventional electrical stimulation at Erb's point (EP), and by magnetic coil stimulation of the supraclavicular region in 11 normal subjects. We found that magnetic coil stimulation was ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880150509
更新日期:1992-05-01 00:00:00
abstract::We investigated 16 patients with Fabry's disease (eight hemizygous men and eight heterozygous women) in one family. We used constant current perception threshold (CPT) testing, which evaluated three major sensory nerve fiber populations, to assess subjective complaints of pain and paresthesias. We also examined clinic...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(199911)22:11<1531::aid-mus
更新日期:1999-11-01 00:00:00
abstract:INTRODUCTION:Nemaline myopathy is a rare disorder characterized by skeletal muscle weakness of varying severity and onset, with the presence of nemaline rods on muscle biopsy. Congenital nemaline body myopathy due to mutations in TNNT1 has hitherto only been described as a result of a single founder mutation in patient...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.24885
更新日期:2016-04-01 00:00:00
abstract::The effects of altering (cross-reinnervation, CR) and/or eliminating (spinal isolation, SI) the activation-dependent neural input to the cat soleus for 8 months on its mechanical and biochemical properties were determined. The percent fast fibers was 0, 27, 38, and 54% for normal control (NC), NC-CR, SI, and SI-CR cat...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4598(199606)19:6<707::AID-MUS4>
更新日期:1996-06-01 00:00:00
abstract:INTRODUCTION:RASopathies are a group of genetic conditions due to alterations of the Ras/MAPK pathway. Neurocutaneous findings are hallmark features of the RASopathies, but musculoskeletal abnormalities are also frequent. The objective was to evaluate handgrip strength in the RASopathies. METHODS:Individuals with RASo...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.23324
更新日期:2012-09-01 00:00:00
abstract:INTRODUCTION:In mitochondrial disease, it is likely that energy substrate depletion leads to paralysis of ATPase-dependent pumps, resulting in membrane depolarization. Axonal depolarization has been demonstrated in a crisis, but not in the resting state. We, therefore, stressed axons using ischemia to see if this would...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.23733
更新日期:2013-05-01 00:00:00
abstract:INTRODUCTION:The risk of cancer in patients diagnosed with myotonic dystrophy (DM) is reported for the homogeneous Utah population. METHODS:Clinical data accessed from the largest Utah healthcare providers have been record-linked to the Utah Population Database, a population-based resource also linked to the Utah Canc...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25145
更新日期:2016-10-01 00:00:00
abstract::The superficial peroneal nerve subserves sensation on the entire surface of the dorsum of the foot, except in small areas. All previously reported techniques for evaluating nerve conduction along this nerve tested a proximal portion of the nerve. We report a new method for evaluating sensory nerve conduction of the fo...
journal_title:Muscle & nerve
pub_type: 临床试验,杂志文章
doi:10.1002/mus.1056
更新日期:2001-05-01 00:00:00
abstract::We report the case of a 27-year-old man treated for bilateral optic neuritis 5 and 3 years before who within a few months developed sensorimotor disorders of the arms and legs characterized by asymmetric distribution and distal prominence. In addition to sensorimotor defects, which were particularly marked in the left...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880171106
更新日期:1994-11-01 00:00:00
abstract::The authors reported a large study of 93 children presenting a severe form of progressive muscular dystrophy. The first clinical symptoms were noticed between 3 to 12 years. The atrophy affects, predominantly, the girdle and truncal muscles. The hypertrophy of the calves is almost consistent. The progression of the di...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880060702
更新日期:1983-09-01 00:00:00
abstract::Motoneurons can be activated both reflexly and antidromically following electrical stimulation of peripheral nerves. These H reflexes and F waves are clinically useful responses which interface at the level of the peripheral nerves and the spinal cord. Because these responses are commonly employed in the electrodiagno...
journal_title:Muscle & nerve
pub_type: 杂志文章,评审
doi:10.1002/mus.880151102
更新日期:1992-11-01 00:00:00
abstract::The lack of effective therapy for many of the chronic neuromuscular diseases such as amyotrophic lateral sclerosis, hereditary motor sensory neuropathy (Charcot-Marie-Tooth disease), spinocerebellar degenerations and idiopathic polyneuropathy has led to a search for substances that may stimulate peripheral nerve regen...
journal_title:Muscle & nerve
pub_type: 杂志文章,评审
doi:10.1002/mus.880130910
更新日期:1990-09-01 00:00:00
abstract::A careful monitoring of the accuracy of diagnosis in six cases of Guillain-Barre syndrome has shown that a substantial proportion of these patients initially diagnosed as having Guillain-Barre syndrome on the basis of characteristic clinical findings and an elevated level of protein in the spinal fluid had a neuropath...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880050206
更新日期:1982-02-01 00:00:00
abstract::To determine whether skeletal muscle oxidative metabolism is impaired in multiple sclerosis (MS), phosphorus magnetic resonance spectroscopy was used to measure the rate of intramuscular phosphocreatine (PCr) resynthesis following exercise in MS and controls. Thirteen MS patients underwent intermittent isometric tetan...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880170802
更新日期:1994-08-01 00:00:00
abstract::To investigate the role of the thymus in the pathogenesis of myasthenia gravis (MG), immunohistochemical expression of CD44, CD45R0, B7-1, and IL-2 was studied in: (1) hyperplastic thymuses of patients with MG whose symptoms markedly improved after thymectomy, (2) remnant thymuses of patients with MG whose symptoms di...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/(sici)1097-4598(200004)23:4<507::aid-mus8>
更新日期:2000-04-01 00:00:00
abstract:INTRODUCTION:Twenty-six patients with clinical symptoms of adult onset carnitine palmitoyltransferase II (CPTII) deficiency were examined. All patients had skeletal muscle CPTII enzyme activity levels indicative of heterozygosity for CPT2 mutations, however sequence analysis identified no pathogenic mutations within th...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.23498
更新日期:2013-02-01 00:00:00
abstract::The intramembrane particle (IMP) profile of control and dystrophic (Bio 14.6) hamster cardiac muscle plasma membrane was assessed in freeze-fracture replicas to determine whether this animal model of muscular dystrophy exhibits the same membrane characteristics found in skeletal muscle from other more thoroughly studi...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.880070702
更新日期:1984-09-01 00:00:00
abstract:INTRODUCTION:Paraneoplastic lower motor neuronopathies have been reported rarely with Hodgkin lymphoma. METHODS:We report a case of rapidly progressive motor neuronopathy preceding the diagnosis of Hodgkin lymphoma. RESULTS:A 31-year-old woman developed subacute rapidly progressive quadriparesis. Electrodiagnostic st...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.23464
更新日期:2012-11-01 00:00:00