Absence of anti-HMG-CoA reductase autoantibodies in severe self-limited statin-related myopathy.

Abstract:

INTRODUCTION:Patients with self-limited statin-related myopathy improve spontaneously when statins are stopped. In contrast, patients with statin-associated autoimmune myopathy have autoantibodies recognizing 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR) and usually require immunosuppressive therapy to control their disease. On initial presentation, it can sometimes be difficult to distinguish between these 2 diseases, as both present with muscle pain, weakness, and elevated serum creatine kinase (CK) levels. The goal of this study was to determine whether patients with severe self-limited statin-related myopathy also make anti-HMGCR autoantibodies. METHODS:We screened 101 subjects with severe self-limited cerivastatin-related myopathy for anti-HMGCR autoantibodies. RESULTS:No patient with severe self-limited cerivastatin-related myopathy had anti-HMGCR autoantibodies. CONCLUSION:Anti-HMGCR autoantibody testing can be used to help differentiate whether a patient has self-limited myopathy due to cerivastatin or autoimmune statin-associated myopathy; these findings may apply to other statins as well. Muscle Nerve 54: 142-144, 2016.

journal_name

Muscle Nerve

journal_title

Muscle & nerve

authors

Floyd JS,Brody JA,Tiniakou E,Psaty BM,Mammen A

doi

10.1002/mus.25127

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

142-4

issue

1

eissn

0148-639X

issn

1097-4598

journal_volume

54

pub_type

杂志文章
  • Carnitine stimulation of pyruvate dehydrogenase complex (PDHC) in isolated human skeletal muscle mitochondria.

    abstract::L-carnitine stimulated CO2 production from 1-14C pyruvate in mitochondria from human skeletal muscle nearly twofold. A comparable increase in the pyruvate dehydrogenase complex (PDHC) activity was seen. Moreover, in the presence of L-carnitine and at pyruvate concentration greater than 0.25 mM, this effect was associa...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880110708

    authors: Uziel G,Garavaglia B,Di Donato S

    更新日期:1988-07-01 00:00:00

  • Skeletal muscle involvement in human immunodeficiency virus (HIV)-infected patients in the era of highly active antiretroviral therapy (HAART).

    abstract::Skeletal muscle involvement can occur at all stages of human immunodeficiency virus (HIV) infection, and may represent the first manifestation of the disease. Myopathies in HIV-infected patients are classified as follows: (1) HIV-associated myopathies and related conditions, including HIV polymyositis, inclusion-body ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,评审

    doi:10.1002/mus.20338

    authors: Authier FJ,Chariot P,Gherardi RK

    更新日期:2005-09-01 00:00:00

  • Electrodiagnostic errors contribute to chronic inflammatory demyelinating polyneuropathy misdiagnosis.

    abstract:INTRODUCTION:Documentation of peripheral nerve demyelination is an important part of the chronic inflammatory demyelinating polyneuropathy (CIDP) diagnostic process. METHODS:We performed a retrospective analysis of patients referred with a diagnosis of CIDP who were found to have a different condition. Electrodiagnost...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.25997

    authors: Allen JA,Ney J,Lewis RA

    更新日期:2018-04-01 00:00:00

  • Differences in excitability properties of FDI and ADM motor axons.

    abstract::The first dorsal interosseous (FDI) and abductor digiti minimi (ADM) muscles are innervated by the same ulnar nerve, but studies have shown that the former is much more severely affected in amyotrophic lateral sclerosis. In this study, threshold tracking was used to investigate whether membrane properties differ betwe...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.21107

    authors: Bae JS,Sawai S,Misawa S,Kanai K,Isose S,Kuwabara S

    更新日期:2009-03-01 00:00:00

  • The effect of temperature on amount and structure of motor variability during 2-minute maximum voluntary contraction.

    abstract:INTRODUCTION:In this study, we questioned whether local cooling of muscle or heating involving core and muscle temperatures are the main indicators for force variability. METHODS:Ten volunteers performed a 2-min maximum voluntary contraction (MVC) of the knee extensors under control (CON) conditions after passive heat...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/mus.23397

    authors: Brazaitis M,Skurvydas A,Pukėnas K,Daniuseviciūtė L,Mickevicienė D,Solianik R

    更新日期:2012-11-01 00:00:00

  • Chronic inflammatory demyelinating polyradiculoneuropathy in children: II. Long-term follow-up, with comparison to adults.

    abstract::We previously reviewed the presentation, initial clinical course, and electrodiagnostic features of children with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). We now report the long-term follow-up of 12 children with idiopathic CIDP, and compare these to 62 adults with idiopathic CIDP. Children of...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-4598(199712)20:12<1569::aid-mus

    authors: Simmons Z,Wald JJ,Albers JW

    更新日期:1997-12-01 00:00:00

  • Organization of the motor-unit pool for different directions of isometric contraction of the first dorsal interosseous muscle.

    abstract:INTRODUCTION:Muscle force generation involves recruitment and firing rate modulation of motor units (MUs). The control of MUs in producing multidirectional forces remains unclear. METHODS:We studied MU recruitment and firing properties, recorded from the first dorsal interosseous muscle, for 3 different directions of ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.25963

    authors: Lei Y,Suresh NL,Rymer WZ,Hu X

    更新日期:2018-01-01 00:00:00

  • Muscle weakness and functional disability in patients with myasthenia gravis.

    abstract:INTRODUCTION:Muscle weakness and functional disability have not been evaluated in a population-based study of patients with myasthenia gravis (MG). METHODS:All patients with MG in a well-defined catchment area were identified in the Danish National Patient Registry. Of the 175 eligible patients, 90 participated and we...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.26356

    authors: Vinge L,Jakobsen J,Andersen H

    更新日期:2019-02-01 00:00:00

  • AAEE Minimonograph #33: electrodiagnostic approach to defects of neuromuscular transmission.

    abstract::Clinical testing for neuromuscular dysfunction is supported by an extensive amount of excellent basic information about normal and abnormal subcellular physiology and ultrastructure. This information provides an essential frame of reference for describing the rationale of single-fiber electromyography (SFEMG). SFEMG i...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,评审

    doi:10.1002/mus.880120802

    authors: Keesey JC

    更新日期:1989-08-01 00:00:00

  • M wave changes with temperature in amyotrophic lateral sclerosis and disorders of neuromuscular transmission.

    abstract::Local cooling of the muscle resulted in significant increases in M wave surface areas in patients with ALS, myasthenia gravis, the Lambert-Eaton myasthenic syndrome, and also in controls. The most striking increases were seen in patients with early ALS who had minimal lower motor neuron involvement and/or little defec...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880130709

    authors: Denys EH

    更新日期:1990-07-01 00:00:00

  • Effects of mexiletine on hyperexcitability in sporadic amyotrophic lateral sclerosis: Preliminary findings from a small phase II randomized controlled trial.

    abstract:BACKGROUND:To collect preliminary data on the effects of mexiletine on cortical and axonal hyperexcitability in sporadic amyotrophic lateral sclerosis (ALS) in a phase 2 double-blind randomized controlled trial. METHODS:Twenty ALS subjects were randomized to placebo and mexiletine 300 or 600 mg daily for 4 wk and asse...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.27146

    authors: Weiss MD,Macklin EA,McIlduff CE,Vucic S,Wainger BJ,Kiernan MC,Goutman SA,Goyal NA,Rutkove SB,Ladha SS,Chen IA,Harms MB,Brannagan TH,Lacomis D,Zivkovic S,Ma M,Wang LH,Simmons Z,Rivner MH,Shefner JM,Cudkowicz ME,A

    更新日期:2020-12-19 00:00:00

  • Analysis of motor unit firing patterns in patients with central or peripheral lesions using singular-value decomposition.

    abstract::We applied the singular value decomposition (SVD) method to study single motor unit firing patterns. Two projects were carried out: (1) a computer simulation study to confirm the meanings of two SVD parameters, the eigenvalue corresponding to the positive-slope eigenvector (PEV) and that corresponding to the negative-...

    journal_title:Muscle & nerve

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-4598(200007)23:7<1057::aid-mus8>3.0.c

    authors: Sun TY,Chen JJ,Lin TS

    更新日期:2000-07-01 00:00:00

  • Compound muscle action potential duration in critical illness neuromyopathy.

    abstract:INTRODUCTION:We sought to determine the specificity of compound muscle action potential (CMAP) durations and amplitudes in a large critical illness neuromyopathy (CINM) cohort relative to controls with other neuromuscular conditions. METHODS:Fifty-eight patients with CINM who had been seen over a 17-year period were r...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.25732

    authors: Kramer CL,Boon AJ,Harper CM,Goodman BP

    更新日期:2018-03-01 00:00:00

  • Experimental model of alcohol-related peripheral neuropathy.

    abstract:INTRODUCTION:The aim of this work was to determine the effect of chronic alcohol exposure on peripheral nerves in a nutritionally balanced rat model of alcoholism. METHODS:Three different strains of adult male rats were pair-fed for 8 weeks with isocaloric liquid diets containing 0% or 37% ethanol. Nerve conduction st...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.23744

    authors: Mellion ML,Nguyen V,Tong M,Gilchrist J,De La Monte S

    更新日期:2013-08-01 00:00:00

  • Validation of diagnostic methods for traumatic sensory neuropathy and neuropathic pain.

    abstract:INTRODUCTION:We evaluated diagnostic value of sensory tests during recovery from iatrogenic sensory neuropathy using intraoperatively verified nerve injury with subjective symptoms as gold standard. METHODS:Inferior alveolar nerves were monitored neurophysiologically throughout mandibular osteotomy in 19 patients. Sen...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.26400

    authors: Teerijoki-Oksa T,Forssell H,Jääskeläinen SK

    更新日期:2019-03-01 00:00:00

  • Electrophysiological diagnosis of interdigital neuropathy of the foot.

    abstract::We have devised a method of sensory nerve conduction in the interdigital nerves of the foot using the near-nerve needle and signal averaging techniques. In 40 normal controls between the ages of 20 and 59, there was no difficulty in recording sensory compound nerve action potential (CNAP) in the various interdigital n...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880070306

    authors: Oh SJ,Kim HS,Ahmad BK

    更新日期:1984-03-01 00:00:00

  • Effects of velocity on maximal torque production in poststroke hemiparesis.

    abstract::Impaired torque production is a major physical impairment following stroke, and has been studied extensively in isometric conditions. However, functional use of a limb requires torque production during movement, and the effects of velocity on maximal torque production may be abnormally enhanced in the paretic limb. Th...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.20157

    authors: Lum PS,Patten C,Kothari D,Yap R

    更新日期:2004-12-01 00:00:00

  • Mitochondrial capacity, muscle endurance, and low energy in friedreich ataxia.

    abstract:INTRODUCTION:In this study we noninvasively evaluated skeletal muscle mitochondrial capacity, muscle-specific endurance, and energy/fatigue feelings in persons with Friedreich ataxia (FRDA) and able-bodied controls (AB). METHODS:Forearm mitochondrial capacity was measured in FRDA (n = 16) and AB (n = 10) study partici...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.25524

    authors: Bossie HM,Willingham TB,Schoick RAV,O'Connor PJ,McCully KK

    更新日期:2017-10-01 00:00:00

  • Endurance training improves skeletal muscle electrical activity in active COPD patients.

    abstract::The effect of endurance training on muscle electrical activity during general exercise testing was investigated in physically active patients with chronic obstructive pulmonary disease (COPD). Before and after rehabilitation, patients performed identical incremental exercise tests. Pulmonary gas exchange, venous lacta...

    journal_title:Muscle & nerve

    pub_type: 临床试验,杂志文章

    doi:10.1002/mus.10491

    authors: Gosselin N,Lambert K,Poulain M,Martin A,Préfaut C,Varray A

    更新日期:2003-12-01 00:00:00

  • Incidence of acetylcholine receptor-antibody-positive myasthenia gravis in South Africa.

    abstract:INTRODUCTION:The aim of this study was to assess age- and gender-specific incidence rates (IRs) of acetylcholine receptor (AChR)-antibody-positive myasthenia gravis (MG) in South Africa, and geographical variations in incidence. METHODS:IRs were calculated from positive AChR-antibody laboratory data between 2011 and 2...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.24348

    authors: Mombaur B,Lesosky MR,Liebenberg L,Vreede H,Heckmann JM

    更新日期:2015-04-01 00:00:00

  • Nerve, muscle, and neuromuscular junction electrophysiology at high temperature.

    abstract::Although the effect of low temperature on the peripheral nervous system has been systematically studied, the effect of high temperature has not. We investigated the effect of elevating limb temperature from 32 degrees C to 42 degrees C by performing sequential motor studies, antidromic sensory studies, and 3-Hz repeti...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-4598(199704)20:4<431::aid-mus5>

    authors: Rutkove SB,Kothari MJ,Shefner JM

    更新日期:1997-04-01 00:00:00

  • Mononeuropathy multiplex associated with acute hepatitis B infection.

    abstract::Immunologic syndromes are associated with hepatitis B viral (HBV) infection. However, mononeuropathy multiplex (MM), a syndrome in which immune factors may play a role, is rare in acute HBV infection. Few cases of MM associated with HBV infection have been reported. We report a case of acute HBV infection in which MM ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880130304

    authors: Cohen JA,Wilborn SL,Rector WG Jr,Golitz LE

    更新日期:1990-03-01 00:00:00

  • Proximal conduction block in the pharyngeal-cervical-brachial variant of Guillain-Barré syndrome.

    abstract:INTRODUCTION:Conduction block (CB) has been included in the Rajabally criteria for axonal Guillain-Barré syndrome (GBS). Because the nerve roots may be affected early in GBS, detection of proximal CB by the triple stimulation technique (TST) can be useful. METHODS:We describe TST findings in 2 patients who presented w...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.24729

    authors: Taieb G,Grapperon AM,Duclos Y,Franques J,Labauge P,Renard D,Yuki N,Attarian S

    更新日期:2015-12-01 00:00:00

  • Guidelines for ethical behavior relating to clinical practice issues in neuromuscular and electrodiagnostic medicine.

    abstract::The American Association of Neuromuscular & Electrodiagnostic Medicine (AANEM) developed guidelines to formalize the ethical standards that neuromuscular and electrodiagnostic (EDx) physicians should observe in their clinical and scientific activities. Neuromuscular and EDx medicine is a subspecialty of medicine that ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.24910

    authors: Abel NA,De Sousa EA,Govindarajan R,Mayer MP,Simpson DA

    更新日期:2015-12-01 00:00:00

  • Variable phenotypes associated with mutations in DOK7.

    abstract::Many patients with the limb-girdle variant of congenital myasthenic syndrome (CMS) possess mutations in the human Dok-7 gene (DOK7). We identified six unrelated CMS patients with DOK7 mutations. Two patients, one mildly and the other moderately affected, were homozygous for the previously described 1263insC mutation. ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.20944

    authors: Anderson JA,Ng JJ,Bowe C,McDonald C,Richman DP,Wollmann RL,Maselli RA

    更新日期:2008-04-01 00:00:00

  • Sural nerve water in vivo in normal humans measured by magnetic resonance spectroscopy: relation to age, height, gender, and neurological profile.

    abstract::To enable the quantitative assessment of peripheral nerve structure and function, we determined the normal values for sural nerve hydration structure as measured by magnetic resonance proton imaging, and for neurological function with scores for neuropathic symptoms, signs, and nerve conduction properties. Normal huma...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880160311

    authors: Eaton RP,Sibbitt WL Jr,Bicknell JM,King MK,Griffey RH,Sibbitt RR

    更新日期:1993-03-01 00:00:00

  • Acquired neuromyotonia and peripheral neuropathy in a patient with Hodgkin's disease.

    abstract::Acquired neuromyotonia is characterized by hyperexcitability of motor nerves resulting in continuous muscle fiber activity. It occurs most often as a paraneoplastic syndrome in patients with cancers of the immune system. Antibodies against voltage-gated potassium channels (VGKCs) have been detected in some patients. P...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.1078

    authors: Lahrmann H,Albrecht G,Drlicek M,Oberndorfer S,Urbanits S,Wanschitz J,Zifko UA,Grisold W

    更新日期:2001-06-01 00:00:00

  • A preparation for studying dystrophic avian muscle and neuromuscular junctions.

    abstract::The extensor of the second digit of the chicken wing (EDII) is a small, fast-twitch muscle susceptible to chicken muscular dystrophy and well suited for correlated studies of the morphology and physiology of identified nerve and muscle fibers. In cross section, the dystrophic EDII shows morphological abnormalities com...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880050103

    authors: Gunther JS,Letinsky MS

    更新日期:1982-01-01 00:00:00

  • Slow-type C-protein in dystrophic chicken fast pectoralis muscle.

    abstract::C-protein isoform expression in hereditary dystrophic chicken skeletal muscle was compared with that in normal chicken muscle during postnatal development by immunocytochemical and immunoblot methods. In the pectoralis muscle (PM) of both normal and dystrophic chicken, slow- and fast-type C-proteins were coexpressed i...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880100412

    authors: Obinata T,Shinbo K

    更新日期:1987-05-01 00:00:00

  • Two patients with GMPPB mutation: The overlapping phenotypes of limb-girdle myasthenic syndrome and limb-girdle muscular dystrophy dystroglycanopathy.

    abstract:INTRODUCTION:Mutations in the guanosine diphosphate-mannose pyrophosphorylase-B gene (GMPPB) have been identified in congenital muscular dystrophies, limb-girdle muscular dystrophy (LGMD2T), and congenital myasthenic syndromes (CMSs); overall, 41 patients have been described. METHODS:Two patients presented with a myas...

    journal_title:Muscle & nerve

    pub_type:

    doi:10.1002/mus.25485

    authors: Montagnese F,Klupp E,Karampinos DC,Biskup S,Gläser D,Kirschke JS,Schoser B

    更新日期:2017-08-01 00:00:00